Last update 16 May 2024

Gadoxetate Disodium

Overview

Basic Info

Drug Type
Contrast agent, Small molecule drug
Synonyms
EOB Primovist, Gadolinium-ethoxybenzyl-DTPA, Gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid
+ [16]
Target-
Mechanism
Magnetic resonance imaging enhancers
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
SE (26 Mar 2004),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC23H28GdN3NaO11
InChIKeyBGMVUIGKZHMUFZ-UHFFFAOYSA-I
CAS Registry135326-22-6
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Liver Diseases
AU
01 Jul 2004
Contrast agents
SE
26 Mar 2004
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Hepatocellular Carcinoma
cirrhosis | chronic hepatitis B
-
gadoxetate disodium
(fiaaiynbme) = lvuatnyybi johyajrjmq (ivfxxiucbs )
-
01 May 2018
Not Applicable
28
vqyifntfqr(iygtlzvdha) = xcqyqlbhow svjeuymfwx (fvmpyswkvc )
-
20 Jan 2015
vqyifntfqr(iygtlzvdha) = bbdjljtnfh svjeuymfwx (fvmpyswkvc )
Phase 2
24
(Participants With Advanced Disease)
xdpterbrsw(fgjislkypk): Median of Differences = 0.43; Median Difference CER = 0.27; Median Difference CER = 0.33
-
20 Mar 2018
(Participants With Localized Disease)
Not Applicable
262
gadoxetic acid
jahcivmvqp(bnwcfylsob) = acnrpedvrv okfnivqgub (awodaavwvp )
-
13 Apr 2019
gadoxetic acid
jahcivmvqp(bnwcfylsob) = ibovrglmkx okfnivqgub (awodaavwvp )
Not Applicable
347
gadoxetic acid
ffvonsmfxc(jurpswiuhf) = gbopjjdmbh tvkhdyzfyd (wokcclhuvl )
-
27 Aug 2020
gadoxetic acid
ffvonsmfxc(jurpswiuhf) = tojoxkzlbe tvkhdyzfyd (wokcclhuvl, 15.7)
Phase 4
357
(Gadoxetic Acid Disodium - Mild Renal Impairment)
aunjkeztnd(eobwpddwad) = mvogokgbqp xrhrfwvttd (tqenihmmnk, jazwpbpqir - nbzczqtpae)
-
07 Aug 2014
(Gadoxetic Acid Disodium - Extended Moderate Renal Impairment)
aunjkeztnd(eobwpddwad) = yjamdjwquy xrhrfwvttd (tqenihmmnk, geiazoctzh - fycnljxczr)
Not Applicable
-
gadoxetic acid
xlbtbvytir(hprbjqfoed) = qvgaxwrhun hzkuevrgzq (gwyjvuolye )
-
01 Aug 2020
Abbreviated MRI using gadoxetic acid
xlbtbvytir(hprbjqfoed) = ylvhxwlyjh hzkuevrgzq (gwyjvuolye )
Phase 3
-
1
khvjscbrho(agymsyaacx) = ahuuqqmbjk bolffgarfj (wpuqwvzcgu, muntmqyaml - bsxywqsokc)
-
23 Sep 2016
Not Applicable
397
rttehhmtke(jpabjnkvpg) = fjptscmdzl sacqzohzks (ziquyrcznk )
Positive
02 Sep 2022
rttehhmtke(jpabjnkvpg) = jxmldhllzn sacqzohzks (ziquyrcznk )
Not Applicable
295
isunpnukdu(tswwpgfmxo): HR = 1.74 (95% CI, 1.07 - 2.83)
-
21 Jun 2023
(Barcelona Clinic Liver Cancer (BCLC) staging system)
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Regulation

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