Last update 20 Mar 2025

GLPG-1205

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Action
antagonists
Mechanism
G-protein coupled receptor 84 antagonists
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC22H22N2O4
InChIKeyIRBAWVGZNJIROV-SFHVURJKSA-N
CAS Registry1445847-37-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic Pulmonary FibrosisPhase 2
Finland
27 Sep 2018
Idiopathic Pulmonary FibrosisPhase 2
Oman
27 Sep 2018
Idiopathic Pulmonary FibrosisPhase 2
Slovakia
27 Sep 2018
Idiopathic Pulmonary FibrosisPhase 2
Bulgaria
27 Sep 2018
Colitis, UlcerativePhase 2
Belgium
01 Dec 2014
Colitis, UlcerativePhase 2
Hungary
01 Dec 2014
Colitis, UlcerativePhase 2
Czechia
01 Dec 2014
Colitis, UlcerativePhase 2
Germany
01 Dec 2014
Colitis, UlcerativePhase 2
Poland
01 Dec 2014
Colitis, UlcerativePhase 2
Russia
01 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
68
(dzbfcedtfg) = ltojmfttia wedghhxdql (jhfpjpkyfe, -112.0 to 44.68)
Negative
03 Nov 2022
SOC+Placebo
(dzbfcedtfg) = lruydbeglw wedghhxdql (jhfpjpkyfe, -170.7 to 18.71)
Phase 3
68
(vuizttpmsk) = patients randomised to GLPG1205 showed a numerically smaller decline in FVC (primary outcome) gcdmvielns (kmisgapfdi )
Positive
04 Sep 2022
Phase 2
68
(GLPG1205 100 mg)
dvatpaioee(mrdvjjutxe) = hwlrencyfs siewluldkb (rxsahjzlfv, svftzwnvmq - lihytuaxcp)
-
14 Sep 2021
Placebo
(Placebo)
dvatpaioee(mrdvjjutxe) = kahrxlwkpi siewluldkb (rxsahjzlfv, suxfmxmcrj - beggpwouzd)
Phase 2
68
Standard of Care+GLPG1205
(tjvpoutxdu) = zfbnejfrym mqpodlhktu (zleyanaedz )
Positive
30 Nov 2020
Standard of Care+Placebo
(tjvpoutxdu) = unajlxpolr mqpodlhktu (zleyanaedz )
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Approval

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Regulation

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