Delving into the Latest Updates on Arctigenin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ARG

Target

ADIPOR1 x PP2A

Mechanism

ADIPOR1 agonists(Adiponectin receptor protein 1 agonists), PP2A stimulants(Protein phosphatase 2A stimulants), Apoptosis stimulants

Therapeutic Areas

Immune System DiseasesEndocrinology and Metabolic DiseaseUrogenital Diseases+ [1]

Active Indication

Diabetic NephropathiesInflammationPeanut Hypersensitivity

Inactive Indication

Pancreatic Cancer

Originator Organization

Kracie Ltd.

Active Organization

Icahn School of Medicine at Mount SinaiLonghua Hospital Shanghai University of TCM

Nephrology, Inc.

Inactive Organization

University of ToyamaKracie Ltd.

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Login to view timeline

Structure

Molecular FormulaC21H24O6

InChIKeyNQWVSMVXKMHKTF-JKSUJKDBSA-N

CAS Registry7770-78-7

Efficacy and safety of HMB/Gln/Arg for the prophylaxis of chemoradiation -induced mucositis in head and neck squamous cell carcinoma: Randomized Phase II Clinical Study - Efficacy and safety of HMB/Gln/Arg for the prophylaxis of chemoradiation -induced mucositis in head and neck squamous cell carcinoma: Randomized Phase II Clinical Study

Start Date01 Mar 2018

Sponsor / Collaborator-

JPRN-UMIN000010111 / CompletedPhase 2IIT

Phase 2a trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine and fluoropyrimidine chemotherapy. - GBS-01 Phase IIa

Start Date11 Mar 2013

Sponsor / Collaborator

National Cancer Center Hospital East

[+1]

JPRN-UMIN000005787 / CompletedIIT

Phase 1/2 study of GBS-01 in patients with gemcitabine-refractory advanced pancreatic cancer. - GBS-01 Phase I/II

Start Date01 Jun 2011

Sponsor / Collaborator

National Cancer Center Hospital East

100 Clinical Results associated with Arctigenin

Login to view more data

100 Translational Medicine associated with Arctigenin

Login to view more data

100 Patents (Medical) associated with Arctigenin

Login to view more data

1,541

Literatures (Medical) associated with Arctigenin

01 Jan 2025·Food Chemistry

Protective effects and molecular mechanisms of Litopenaeus vannamei treated with l-arginine/l-lysine against myofibrillar proteins oxidation and quality degradation during freeze-thaw cycles

Article

Author: Luo, Wenwen ; He, Mengxue ; Sun, Jianan ; Zhang, Yejun ; Mao, Xiangzhao

The storage and processing of Litopenaeus vannamei are often challenged by the freeze-thaw (F-T) cycle phenomenon. This study delved into the influence of pretreatment with l-arginine (Arg) and l-lysine (Lys) on the myofibrillar proteins oxidation and quality of shrimp subjected to F-T cycles. Arg and Lys pretreatment notably improved water-holding capacity (WHC), textural integrity as well as the myofibrillar structure of the shrimps. A lesser reduction in the amounts of immobile and bound water was found in the amino acid-treated groups, and the oxidation of lipids and proteins were both decelerated. Molecular simulation results indicated that Arg and Lys could form hydrogen and salt-bridge bonds with myosin, enhancing the stability of Litopenaeus vannamei. The study concludes that Arg and Lys are effective in alleviating the adverse effects of F-T cycles on the quality of Litopenaeus vannamei, and provides a new solution for the quality maintenance during storage and processing.

01 Dec 2024·Journal of Muscle Research and Cell Motility

Arginine ingestion inhibits phagocyte invasion in eccentrically contracted rat fast-twitch muscle

Article

Author: Wada, Masanobu ; Kanzaki, Keita

AbstractEccentric contraction (ECC) has been shown to induce leukocyte invasion into skeletal muscle, resulting in muscle inflammation. This study aimed to investigate whether prior ingestion of L-arginine (ARG), a nitric oxide precursor, inhibits ECC-induced macrophage invasion. Male Wistar rats received ARG in water for 7 days, beginning 3 days prior to ECC. ECCs were induced in the anterior crural muscles for 200 cycles. Three days later, the tibialis anterior and extensor digitorum longus muscles were excised for biochemical analysis and force measurement, respectively. ARG ingestion increased nitrite and nitrate levels in plasma and muscle, inhibiting force depression and reducing CD68 content in muscles subjected to ECC. ARG ingestion also ameliorated an ECC-induced increase in protein nitration, although neither ARG ingestion nor ECC induction affected protein carbonyl levels. The present results suggest that ingestion of ARG or ARG-rich foods may alleviate inflammation by attenuating phagocyte invasion in eccentrically contracted skeletal muscles.

01 Dec 2024·Tissue and Cell

L‐arginine mitigates choroid plexus changes in Alzheimer’s disease rat model via oxidative/inflammatory burden and behavioral modulation

Article

Author: Fattah, Islam Omar Abdel ; El-Din, Wael Amin Nasr ; Nasr El-Din, Wael Amin ; Abdel Fattah, Islam Omar

Aging is a risk factor for Alzheimer's disease (AD), leading to choroid plexus (CP) alterations. This study aimed to explore the possible therapeutic mechanisms of ARG on AD-induced CP changes. Sprague-Dawley rats were divided into 6 groups (n = 7 per group): adult, adult+ARG, aged, aged+ARG, aged+AD, and aged+AD+ARG groups. Evaluations were for Y-maze test, serum levels of oxidative/inflammatory markers, and serum and cerebrospinal fluid (CSF) markers of AD, histopathology, immunohistochemistry, and histomorphometry. The aged+AD group demonstrated a significant decline in maze test parameters, total antioxidant capacity (TAC), brain-derived neurotrophic factor (BDNF) levels, and vascular endothelial growth factor (VEGF) immunoexpression, while tumour necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), beta-amyloid (Aβ) levels and amyloid protein precursor (APP), and heat shock protein90 (HSP90) immunoexpressions were significantly increased. Sections of this group showed flat epitheliocytes, congested capillaries, connective tissue expansion, and degenerated endothelium. These parameters were modulated by ARG administration, via increased levels of TAC (1.37 vs 2.17 mmol/L), (p = 0.018) BDNF (serum: 48.50 vs 78.41; CSF: 4.07 vs 7.11 pg/ml) (p< 0.001), and VEGF (0.07 vs 0.26 OD) (p< 0.001), in addition to decreased levels of TNF-α (86.63 vs 41.39 pg/ml) (p< 0.001), IL-1β (96.04 vs 39.57 pg/ml) (p< 0.001), Aβ (serum: 67.40 vs 47.30; CSF: 189.26 vs 169.84 pg/ml) (p< 0.001), and HSP90 (0.54 vs 0.13 OD) (p< 0.001). In conclusion, ARG ameliorates the AD-associated CP changes, including histopathological, oxidative/inflammatory, and AD markers, and VEGF and HSP90 immunohistochemical alterations. Dietary ARG consumption is recommended to avoid AD progression in the elderly.

100 Deals associated with Arctigenin

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
-	Arctigenin	B05XB01	DB00125

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Diabetic Nephropathies	Preclinical	-	Nephrology, Inc.	15 Nov 2016
Diabetic Nephropathies	Preclinical	CN	Longhua Hospital Shanghai University of TCM	15 Nov 2016
Inflammation	Preclinical	US	Icahn School of Medicine at Mount Sinai	01 Feb 2016
Peanut Hypersensitivity	Preclinical	US	Icahn School of Medicine at Mount Sinai	01 Feb 2016
Pancreatic Cancer	Discovery	-	University of Toyama	-
Pancreatic Cancer	Discovery	-	Kracie Ltd.	-
Pancreatic Cancer	Discovery	JP	-	-

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


JPRN-UMIN000005787 (ASCO2013)	Phase 1	Pancreatic Cancer	15	GBS-01 3g	(rlybpyslle) = vnmlbbkxcd vvekaxuviu (wzkjmxxbrj ) View more	-	20 May 2013
				GBS-01 7.5g	(rlybpyslle) = eorvaszyaq vvekaxuviu (wzkjmxxbrj ) View more