Delving into the Latest Updates on Longhua Hospital Shanghai University of TCM with Synapse

Overview

Tags

Neoplasms

Digestive System Disorders

Nervous System Diseases

Herbal medicine

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Immune System Diseases	1
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Herbal medicine	3
Small molecule drug	2

Top 5 Target	Count

ADIPOR1 x PDHK1 x PP2A	1
MZF1(myeloid zinc finger 1)	1

The goal of this clinical study is to compare the effects of combined electroacupuncture with pelvic floor muscle training (PFMT) versus PFMT alone in the treatment of involuntary urine leakage following prostate removal procedure due to prostate cancer. The main question it aims to answer is that whether adding electroacupuncture to PFMT provides extra benefits in relieve urinary leakage and improves patients' quality of life. All participants will be required to perform daily PFMT for 6 weeks using uniformed standards. During the meantime, those assigned to the experimental group will additionally receive electroacupuncture three times per week for 6 weeks, while those in control group will receive sham treatment with same duration. Researchers will compare the urine leakage severity between the two groups to see if adding electroacupuncture can facilitate the recovery of symptom.

Start Date01 Dec 2023

Sponsor / Collaborator

Longhua Hospital Shanghai University of TCM

100 Clinical Results associated with Longhua Hospital Shanghai University of TCM

Login to view more data

0 Patents (Medical) associated with Longhua Hospital Shanghai University of TCM

Login to view more data

179

Literatures (Medical) associated with Longhua Hospital Shanghai University of TCM

31 Dec 2025·Annals of Medicine

Cardiopulmonary fitness in children/adolescents with chronic kidney disease and the impact of exercise training: a systematic review and meta-analysis of observational study and randomized controlled trials

Review

Author: Zhang, Fan ; Zhong, Yifei ; Huang, Liuyan ; Bai, Yan

BACKGROUNDThis systematic review and meta-analysis aimed to evaluate differences in cardiopulmonary fitness between healthy controls and children/adolescents with chronic kidney disease (CKD) and the effects of exercise training.METHODSPubMed, Embase, Scopus and Web of Science were searched for published studies from reception to 14 June 2023, and updated search on 15 October 2023. The included observational studies reported on cardiorespiratory fitness, included maximal oxygen uptake (VO_2max), peak oxygen consumption (VO_2peak) and 6-minute walk distance (6MWD), in children/adolescents with CKD and age-matched healthy controls, as well as clinical intervention trials of exercise training on cardiorespiratory fitness in samples of children and/or adolescents up to 19.RESULTSFifteen observational studies and five clinical trials were included, respectively. The studies found that the mean cardiopulmonary fitness was 1.82 standardized mean differences (SMDs) units (95% confidence interval (95% CI) 1.43-2.20) lower in children/adolescents with CKD than in healthy controls or reference values. Except for pre-dialysis CKD patients, peritoneal dialysis, haemodialysis and kidney transplant recipients had significantly lower cardiorespiratory fitness than healthy controls. The results of a meta-analysis based on a pre-post single-arm trial showed that compared to baseline, exercise training improved the 6MWD by approximately 58.17 m (95% CI 16.27-100.06), with very low evidence.CONCLUSIONSThis systematic review and meta-analysis of observational studies and clinical trials that included children/adolescents with CKD found that cardiorespiratory fitness is severely reduced in this population and that exercise training may be an effective strategy for improvement. Given the low evidence certainty, additional high-quality trials are necessary.

01 Jun 2025·Clinical Nutrition ESPEN

Association of sarcopenia index, a surrogate marker of muscle mass, and incident chronic kidney disease

Article

Author: Zhang, Fan ; Li, Yi ; Chu, Aojiao ; Huang, Liuyan ; Bai, Yan ; Zhong, Yifei

BACKGROUNDSarcopenia, characterized by loss of muscle mass and strength, has been linked to various health outcomes, including chronic kidney disease (CKD). This study aims to investigate the association of sarcopenia index, based on serum creatinine and cystatin C levels, with incident CKD in middle-aged and older adults.METHODSThis study extracted data from a nation cohort, including age ≥45 years adults without CKD at baseline. Sarcopenia index was calculated based on serum creatinine and cystatin C levels, and incident CKD was assessed through follow-up surveys. Cox proportional hazards regression models were used to analyze the association between sarcopenia index and incident CKD, adjusting for potential confounders, with hazard ratio (HR) with 95 % confidence interval (95 % CI) reported.RESULTSA total of 8618 participants were included in the analysis. The median age was 61.0 years, and 44.7 % were male. During a mean follow-up period of 5.0 years, 514 cases of incident CKD were identified. After adjusting for covariates, compared with participants in the lowest tertile, the corresponding CKD HRs (95 % CIs) for participants in the medium and highest tertile were 0.701 (95 % CI: 0.558-0.880, P = 0.002), 0.784 (95 % CI: 0.618-0.994; P = 0.045). Restricted cubic spline curves revealed that incident rate decreased with increase in sarcopenia index.CONCLUSIONThis study provides national longitudinal evidence on the association of higher sarcopenia index with lower incident CKD. Our findings suggest that sarcopenia index may be a useful biomarker for predicting the risk of CKD in this population.

01 May 2025·Diabetes Research and Clinical Practice

Letter to “Daytime napping and risk of incident main adverse cardiovascular events and mortality among adults with type 2 diabetes”

Letter

Author: Qiao, Siyu ; Chen, Yuelai

100 Deals associated with Longhua Hospital Shanghai University of TCM

Login to view more data

100 Translational Medicine associated with Longhua Hospital Shanghai University of TCM

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 09 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

Phase 2 Clinical

Phase 3 Clinical

1

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Shenqi Sherong Pills	Cervical myelopathy More	Phase 3
Fuhuang Tablets	Interno-external hemorrhoid More	Phase 2
Shuanghuang Shengbai Oral Liquid	Neutropenia More	Phase 2
Arctigenin ( ADIPOR1 x PDHK1 x PP2A )	Diabetic Nephropathies More	Preclinical
Solamargine ( MZF1 )	Hepatocellular Carcinoma More	Preclinical