Delving into the Latest Updates on PPRT-152 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication-

Inactive Indication

Depressive Disorder, Major

Originator Organization

PharmaPrint, Inc.

Active Organization-

Inactive Organization

PharmaPrint, Inc.

License Organization-

Drug Highest PhasePendingClinical

First Approval Date-

Regulation-

Abstract:Approximately one-third of Americans use healthcare approaches including herbs and botanicals, such as St. John's wort (SJW), to improve overall well-being, gain control over their health, and manage the adverse reactions of conventional therapies. This article examines the use of SJW in cancer care, discussing its pharmacokinetics, toxicity, and potential interactions with cancer treatments while emphasizing the importance of patient education and collaboration between oncology nurses and pharmacists to ensure safe and effective care.

01 Aug 2024·Clinical and Translational Science

Dose‐dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin

Article

Author: Hohmann, Nicolas ; Blank, Antje ; Mikus, Gerd ; Haefeli, Walter E. ; Friedrichs, Anna S. ; Burhenne, Jürgen

AbstractThe dose dependence of the effect of enzyme inducers and the effect of the combined administration of two inducers that exert their effect via the same induction pathway (pregnane X receptor) have not been well studied. Using oral midazolam microdoses (30 μg), we have investigated CYP3A4 induction by St. John's wort (SJW) in 11 healthy volunteers using low (300 mg/day containing 7.48 mg hyperforin), therapeutic (900 mg/day), and supratherapeutic doses of SJW (1800 mg/day) for 14 days. SJW was then co‐administered with rifampin (600 mg/day) for a further 7 days to evaluate the effect of the combined administration of two inducers. In addition, intravenous midazolam microdoses (10 μg) were administered before SJW, at SJW 1800 mg/day, and during administration of the two inducers to assess the hepatic contribution to total induction (semi‐simultaneous administration). Administration of SJW increased oral midazolam clearance 1.96‐fold (300 mg/day), 3.86‐fold (900 mg/day), and 5.62‐fold (1800 mg/day), and 17.5‐fold after the addition of rifampin. Concurrently, the clearance of intravenous midazolam increased 2.05‐fold (1800 mg/day) and 2.93‐fold (SJW + rifampin). These results show that rifampin significantly enhances the induction of the highest SJW doses both hepatically and overall and suggest that these metabolic effects occur predominantly in the gut. These findings also suggest that in drug interactions involving strong and moderate enzyme inducers, the perpetrator effects of the strong inducer are decisive for the interaction.

01 Apr 2024·Pain Management Nursing

The Effect of St. John's Wort Oil (Hypericum Perforatum L.) in Knee Osteoarthritis: A Randomized Controlled and Qualitative Study

Article

Author: Sönmez, Deniz Zeynep ; Taşcı, Sultan

BACKGROUNDReducing pain and improving physical function are critical in the treatment of osteoarthritis. Although individuals use St. John's Wort oil to relieve pain due to osteoarthritis, no scientific research has been found investigating its effectiveness.AIMThis study investigated the effect of St. John's Wort oil on pain intensity and physical functions in people with knee osteoarthritis.METHODSThis study adopted a single-blind, randomized, placebo-controlled, and qualitative mixed design. The sample consisted of 60 patients randomized into intervention (n = 30) and placebo control (n=30) groups. The experimental group participants were treated with topically St. John's Wort oil three times a week for 3 weeks, and the placebo control group participants were treated with olive oil three times a week for 3 weeks. Quantitative data were collected using a patient identification form, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Visual Analogue Scale. Qualitative data were collected through semi-structured interviews.RESULTSThe experimental group had a significantly lower mean Visual Analog Scale score in the first, third, and fourth follow-ups than the control group. The experimental group had significantly lower mean WOMAC-pain, WOMAC-stiffness, and WOMAC-physical function subscale scores in the last follow-up than in the first follow-up. The qualitative data agreed with the quantitative data.CONCLUSIONSThe results show that St. John's Wort oil helps people with knee osteoarthritis feel less pain and become physically more active. Additional research is warranted to better understand the effect of St. John's Wort oil on pain intensity and physical functions in people with knee osteoarthritis.

100 Deals associated with PPRT-152

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


MON-429 (ENDO2019)	Not Applicable	Pulmonary hypertensive crisis	-	St. John's Wort	jbblybxkzb(bcgphsdefn) = Hypertensive crisis in a young woman with use of St. John's Wort for depression knnmqpjmfr (veteboisyl ) View more	-	30 Apr 2019
				Amlodipine
EASD2012	Not Applicable	-	-	St. John's Wort extract	xxdtrzemuu(kmavxtones) = partially corrected the cytokine-induced unbalance between anti- and pro-apoptotic factors gikrgcvspx (biisqukauy ) View more	Positive	04 Oct 2012
				Hyperforin
IAS2001	Not Applicable	-	600	St. John's wort users	(iwbfjmodwn) = ccoeqexyfr msajvqstib (pudcdcbfmw, -4 to to 163) View more	-	01 Jan 2001