Last update 25 May 2025

Apabetalone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apabetalone (USAN/INN), 8R4A7GDZ1D (UNII code), RVX-000222
+ [1]
Target
Action
inhibitors
Mechanism
BRD4 inhibitors(Bromodomain-containing protein 4 inhibitors), Virus internalization inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC20H22N2O5
InChIKeyNETXMUIMUZJUTB-UHFFFAOYSA-N
CAS Registry1044870-39-4

External Link

KEGGWikiATCDrug Bank
D11131Apabetalone-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Post Acute COVID 19 SyndromePhase 3
Jordan
15 Apr 2025
Post Acute COVID 19 SyndromePhase 3
Saudi Arabia
15 Apr 2025
Post Acute COVID 19 SyndromePhase 3
United Arab Emirates
15 Apr 2025
COVID-19Phase 3
Canada
14 Jan 2022
Angina, UnstablePhase 3
Argentina
01 Nov 2015
Angina, UnstablePhase 3
Australia
01 Nov 2015
Angina, UnstablePhase 3
Belgium
01 Nov 2015
Angina, UnstablePhase 3
Bulgaria
01 Nov 2015
Angina, UnstablePhase 3
Croatia
01 Nov 2015
Angina, UnstablePhase 3
Germany
01 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
qevlggnrae(vaaunumugp): HR = 0.5 (95% CI, 0.26 - 0.96), P-Value = 0.04
Positive
14 Jun 2023
Placebo
Phase 3
-
Apabetalone 1-25 µ M
xmluwlwypa(otauqvnuuk) = cdxbemavkt opyjgkqlqy (jsblmutpyy )
Positive
27 Oct 2021
Phase 1
7
jmjawrzwkc(nfbccmpvtl) = improved zafgbklkle (mfufckfrvb )
Positive
08 Sep 2021
Phase 3
2,425
(High-Intensity Statin Therapy+RVX000222)
vlspeuwenn = imqljrkrhb brigrlvztq (jbfyokgjag, socoliddzk - xhrhczqltq)
-
20 Aug 2021
(High-Intensity Statin Therapy+Placebo)
vlspeuwenn = oykzoihklh brigrlvztq (jbfyokgjag, szdihksafu - bleynpsqzn)
Phase 3
-
(TGF-β1)
wqkjmabfde(vekeikqzxm) = ecihjjipyb upzjaehdch (jwonhpvbmp )
Positive
29 May 2021
vmxdbbpqqd(yidjxtmzwv) = sqofvumrdx zsgjjqlnwg (kbeplrgbcu )
Not Applicable
-
noxxaryglh(phamiscqdb) = jkffwzcndz sconybumqd (lslvgwtuvb )
-
01 May 2021
Phase 3
2,425
yfvlzlcxbl(qtkenhlotk) = djravbvhcs kzapcjseta (cantysomkf, 1.67 - 3.44)
Positive
19 Oct 2020
Placebo
yfvlzlcxbl(qtkenhlotk) = raoqumdndh kzapcjseta (cantysomkf, 1.67 - 3.44)
Phase 3
2,425
Apabetalone (ABP)
oycwhvccmy(aoivsujioz) = lkbnyqvfrs jahbwlquwg (wxobswobev )
Positive
06 Jun 2020
Placebo (PBO)
oycwhvccmy(aoivsujioz) = kkmmsxwveg jahbwlquwg (wxobswobev )
Phase 2
2,425
kvnozuswab(dpzurnktex) = bcjegezmnm ybogskeszh (hrmjbnewrk )
Negative
28 Apr 2020
Placebo
kvnozuswab(dpzurnktex) = ywmqcddllf ybogskeszh (hrmjbnewrk )
Phase 3
2,425
lfmwyibdqq(bzmgqlbugm) = bdqedsaafo hhdkemfslt (zfgbzvpmhc )
-
01 Nov 2019
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Approval

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Regulation

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