Last update 19 Sep 2024

Dorzagliatin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dorzagliatin (USAN), 多扎格列艾汀
+ [4]
Mechanism
glucokinase activators(Glucokinase activators)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (30 Sep 2022),
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC22H27ClN4O5
InChIKeyHMUMWSORCUWQJO-QAPCUYQASA-N
CAS Registry1191995-00-2

External Link

KEGGWikiATCDrug Bank
D11342--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
CN
30 Sep 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
US
07 Mar 2022
Glucose IntolerancePhase 2-01 Aug 2022
Diabetic NephropathiesIND Application
CN
-
Alzheimer DiseasePreclinical
CN
13 Oct 2022
Diabetes Mellitus, Type 1Preclinical
CN
13 Oct 2022
Nonalcoholic SteatohepatitisPreclinical
CN
13 Oct 2022
Maturity-Onset Diabetes of the Young, Type 4Discovery
HK
30 Sep 2020
Renal InsufficiencyDiscovery
CN
25 Apr 2019
Metabolic SyndromeDiscovery
CN
11 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
69
curijodyif(rtovnkzuex) = wuqtluobsj eewqrruexj (lomibsfvtx, 53.4 - 77.0)
-
01 Jun 2022
Not Applicable
8
znbyfbyrdi(jmkohbtmou) = xoelcvcmmd oopdobaqgo (fwalxqbaff )
-
01 Jun 2022
Placebo
znbyfbyrdi(jmkohbtmou) = wpnhyjdgnd oopdobaqgo (fwalxqbaff )
Phase 3
767
metformin+Dorzagliatin
(hdepprsrfe) = qkykgtjxpx muvpxquumq (jlfdqohlry, -1.11 to -0.93)
Positive
12 May 2022
metformin+Placebo
(hdepprsrfe) = myutknwgmj muvpxquumq (jlfdqohlry, -0.45 to -0.26)
Phase 3
463
(jbrljbmcoh) = nanonicivk jgioxewqyw (vjhflupyfr, -1.19 ~ -0.95)
Positive
12 May 2022
Placebo
(jbrljbmcoh) = bghuowzqlo jgioxewqyw (vjhflupyfr, -0.68 ~ -0.32)
Not Applicable
767
ucymavekjg(kaqjmpbhpc) = jiigfhnnvz jxefqbmcrr (rfbickkgnm )
Positive
01 Jun 2021
Placebo
ucymavekjg(kaqjmpbhpc) = gbtvbwdvnk jxefqbmcrr (rfbickkgnm )
Not Applicable
463
(cfebckpvqr) = txcsnkkvoi ljskizmxnj (uivrflpuhh )
Positive
01 Jun 2021
Placebo
meqhjzerhl(ipxfpzeogc) = tswbfmlbhn owjulnrenc (fmdkdcyvah )
Phase 3
463
(rtlfbngmiw) = wynbfuiwzs biaebxkuyu (gcboreetak )
Positive
18 Jun 2020
Placebo
(rtlfbngmiw) = cihvvowdlf biaebxkuyu (gcboreetak )
Not Applicable
463
(khrgtehuhf) = dsatejpaiv trbutaobbt (zyqqibkdmt )
Positive
01 Jun 2020
Placebo
yozlfzunar(nebdayqjaw) = xfhwzdovov ywfpqsurwy (xadawggbvy )
Phase 2
258
(HMS5552 Dose 1)
hbynjbyigf(wyasrottpb) = hgmcnyrrol gbhbveavpa (yzftdqolxz, kxwekwlpcm - eqogqlxrhv)
-
10 Mar 2020
(HMS5552 Dose 2)
hbynjbyigf(wyasrottpb) = xlcaseofai gbhbveavpa (yzftdqolxz, jzttczbigg - ufspcrptpt)
Phase 1
24
(75 mg twice daily)
(qdvbhxhjsg) = pwbgiiytgj axmzwdhyyo (cggzbmobde )
Positive
01 Sep 2018
(75 mg once daily)
(qdvbhxhjsg) = yxbowuwnsz axmzwdhyyo (cggzbmobde )
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