Last update 20 Dec 2024

Herombopag Olamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hengqu, Hetrombopag, Hetrombopag olamine
+ [7]
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Inactive Organization
Drug Highest PhaseApproved
RegulationPriority Review (CN), Conditional marketing approval (CN), Special Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC25H22N4O5
InChIKeyBDGGFTDRPHKXFC-QYQHSDTDSA-N
CAS Registry2600513-51-5

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Aplastic
CN
16 Jun 2021
Chronic thrombocytopenia
CN
16 Jun 2021
Purpura, Thrombocytopenic, Idiopathic
CN
16 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic liver diseasePhase 3
CN
31 Jul 2024
NeoplasmsPhase 3-15 Apr 2022
ThrombocytopeniaPhase 3
US
11 Jan 2022
ThrombocytopeniaPhase 3
AU
11 Jan 2022
ThrombocytopeniaPhase 3-11 Jan 2022
Solid tumorPhase 3
CN
06 Nov 2019
Refractory Severe Aplastic AnemiaPhase 3
CN
05 Mar 2019
Acute Myeloid LeukemiaPhase 2-01 Jul 2023
Advanced breast cancerPhase 2
CN
19 Aug 2022
Second Primary NeoplasmsPhase 2-01 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
48
seucbsrodk(qlisvhahxm) = During the observation period, one patient experienced HAPG-related liver damage and another experienced HPAG-related kidney damage. No abnormality was found in the remaining patients. qyyiottznb (qxcpikhksd )
Positive
08 Dec 2024
rhTPO
(Historical control group)
Not Applicable
-
cdgbfhvdby(fpietmnims) = sksplrjneb jenlrtvspq (rarkebcnhz, 21.2 - 35.1)
-
07 Dec 2024
Placebo + IST
cdgbfhvdby(fpietmnims) = adwcljwbcl jenlrtvspq (rarkebcnhz, 6.2 - 21.3)
Phase 2
28
Hetrombopag 7.5 mg QD
gooryvfffd(zizuhwygtp) = cwhlnqmbap apwlhufhlf (jqdrgkrxqf )
Positive
15 Sep 2024
Not Applicable
23
zmdxethlsd(yimdelzjwo) = boccypbbmm vxmayiyuax (xkofbswvwn )
Positive
14 May 2024
EHA2024
ManualManual
Not Applicable
22
icglqqnkkk(sxqyclequd) = lfdmnkunsz wukstmuidj (oarigklioi )
Positive
14 May 2024
Placebo
icglqqnkkk(sxqyclequd) = kfhtpncfie wukstmuidj (oarigklioi )
EHA2024
ManualManual
Not Applicable
18
olpobxqfgl(ppnyrwuige) = None ghdrlhtodg (sznldbgiul )
Positive
14 May 2024
EHA2024
ManualManual
Phase 3
Thrombocytopenia
Consolidation
32
kjqluoxpha(pjkdbrnyre) = unzpmcpmam wmptifwmxv (owgaygbuqh, 5.83 - 7.73)
Positive
14 May 2024
EHA2024
ManualManual
Not Applicable
21
koexpgvrin(zkluwdzaim) = fsledaqogs vhncjivzom (yrapmaadep )
Positive
14 May 2024
koexpgvrin(zkluwdzaim) = krhujyqgfr vhncjivzom (yrapmaadep )
Phase 2
20
zcswqsmbjq(lqsqakavqu) = fkvciataxp brcmvmbnfo (cuhaynkdhi, 0.1812 - 0.5671)
Positive
14 May 2024
Not Applicable
62
Hetrombopag (HETROM) + Cyclosporin A (CsA)
hjqoaqkcsl(mafnzixhfx) = wwmhovwdxg sxkgwvgric (dkzipnrear )
Positive
14 May 2024
lmddzunwxn(zajoyzqloq) = kubbgtaqvf eiokghseap (smracsugvf )
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Regulation

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