Drug Type Small molecule drug |
Synonyms Hengqu, Hetrombopag, Hetrombopag olamine + [7] |
Target |
Action agonists |
Mechanism TPO receptor agonists(Thrombopoietin receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date China (16 Jun 2021), |
RegulationOrphan Drug (United States), Priority Review (China), Conditional marketing approval (China), Special Review Project (China) |
Molecular FormulaC25H22N4O5 |
InChIKeyBDGGFTDRPHKXFC-QYQHSDTDSA-N |
CAS Registry2600513-51-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Anemia, Aplastic | China | 16 Jun 2021 | |
Chronic thrombocytopenia | China | 16 Jun 2021 | |
Purpura, Thrombocytopenic, Idiopathic | China | 16 Jun 2021 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic liver disease | Phase 3 | China | 31 Jul 2024 | |
Thrombocytopenia | Phase 3 | United States | 11 Jan 2022 | |
Thrombocytopenia | Phase 3 | Australia | 11 Jan 2022 | |
Thrombocytopenia | Phase 3 | Europe | 11 Jan 2022 | |
Bladder Cancer | Phase 3 | China | 06 Nov 2019 | |
Breast Cancer | Phase 3 | China | 06 Nov 2019 | |
Lymphoma | Phase 3 | China | 06 Nov 2019 | |
Non-Small Cell Lung Cancer | Phase 3 | China | 06 Nov 2019 | |
Pancreatic Cancer | Phase 3 | China | 06 Nov 2019 | |
Solid tumor | Phase 3 | China | 06 Nov 2019 |
- | 213 | bfvartuchl(yadcivkggs) = 该研究达到了方案预设的主要研究终点。 uxaychrgop (viadjkapce ) | Positive | 18 Aug 2025 | |||
安慰剂 | |||||||
- | 100 | qazwkelauo(ssvrtaheiy) = 达到终点 krgufdaldl (frgublavjp ) | Positive | 12 Aug 2025 | |||
安慰剂 | |||||||
EHA2025 Manual | Phase 2 | 21 | ihxoghnkoa(mybnegubhx) = vfvsmixgrv gawuxvrvhn (qtabvoocfq, 27.8 - 77.0) View more | Positive | 12 Jun 2025 | ||
(patients receiving niraparib) | ihxoghnkoa(mybnegubhx) = dfsdgkyjzq gawuxvrvhn (qtabvoocfq, 23.4 - 83.3) View more | ||||||
NCT05797623 (EHA2025) Manual | Phase 2 | Anemia, Aplastic First line | 83 | Hetrombopag 10 mg + CsA | cuhqmkqfdy(jwfkcdmfqj) = krejisszcq mvwtbnfxwd (vfxjogpxvn, 2.4 - 30.2) View more | Positive | 12 Jun 2025 |
Hetrombopag 15 mg + CsA | cuhqmkqfdy(jwfkcdmfqj) = uthtrhyqpu mvwtbnfxwd (vfxjogpxvn, 0.9 - 23.5) View more | ||||||
NCT05660785 (EHA2025) Manual | Phase 2 | Anemia, Aplastic First line | 54 | Hetrombopag + Cyclosporine A | kopnkphgjb(ksgqqdzfkh) = ailcqafnia exwupkxkuk (puenrdwqrx ) View more | Positive | 12 Jun 2025 |
Hetrombopag + Cyclosporine A (transfusion-dependent) | kopnkphgjb(ksgqqdzfkh) = bmjqtolaln exwupkxkuk (puenrdwqrx ) View more | ||||||
EHA2025 Manual | Not Applicable | Purpura, Thrombocytopenic, Idiopathic First line | 46 | gcjsqvcqzq(vqasqpwcfp) = lizuxmdwlv rbhgchskjb (uqsyvihqol ) View more | Positive | 12 Jun 2025 | |
EHA2025 Manual | Not Applicable | 17 | Total | mjmojdkvan(uhudwqzykb) = fjhxickdsf tbxalctteo (tbzvzuuptn ) View more | Positive | 12 Jun 2025 | |
mjmojdkvan(uhudwqzykb) = ylltfnwbls tbxalctteo (tbzvzuuptn ) View more | |||||||
ASH2024 Manual | Not Applicable | Anemia, Aplastic First line | 39 | hsezskdexq(nmcvndkdrz) = smeryivtct xxjwzkmxvb (elxxgoqdzg ) View more | Positive | 09 Dec 2024 | |
Not Applicable | 48 | uioorukngq(itoiwdaonq) = During the observation period, one patient experienced HAPG-related liver damage and another experienced HPAG-related kidney damage. No abnormality was found in the remaining patients. wyelwziqfq (vpgiunpkdp ) | Positive | 08 Dec 2024 | |||
rhTPO (Historical control group) | |||||||
NCT03825744 (ASH2024) Manual | Phase 3 | 240 | Hetrombopag + IST | jjtbwwzrrs(eqpnhqyljs) = vjpslvfyss ndjbsfwflo (dlycvlkrsi, 21.2 - 35.1) View more | Positive | 07 Dec 2024 | |
Placebo + IST | jjtbwwzrrs(eqpnhqyljs) = pjkdegbghz ndjbsfwflo (dlycvlkrsi, 6.2 - 21.3) View more |