Last update 21 Nov 2024

Trastuzumab Rezetecan

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Trastuzumab-rezetecan
+ [1]
Target
Mechanism
HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US), Breakthrough Therapy (CN), Priority Review (CN)
Login to view timeline

Structure

Molecular FormulaC26H34N6O7
InChIKeyLETKGXXMROUGGW-IBGZPJMESA-N
CAS Registry-
Boost your research with our ADC technology data.
Boost your research with our ADC technology data.

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
HER2 mutant non-small cell lung cancerNDA/BLA
CN
14 Sep 2024
Colorectal CancerPhase 3
CN
01 Mar 2024
HER2-positive gastric cancerPhase 3
CN
09 Jan 2024
HER2 positive Gastroesophageal Junction AdenocarcinomaPhase 3
CN
28 Dec 2023
HER2 positive Gastrooesophageal junction cancerPhase 3
CN
28 Dec 2023
HER2 Positive Breast CancerPhase 3-01 Oct 2023
HER2-Low Breast CarcinomaPhase 3
CN
05 Jun 2023
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 3
CN
04 Aug 2022
Unresectable Breast CarcinomaPhase 3
CN
04 Aug 2022
Advanced Lung Non-Small Cell CarcinomaPhase 2
CN
23 Apr 2021
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
307
(qwirpgkuqu) = wyqfeihvoq vtqqcwkaao (qtldmiekhc )
Positive
10 Oct 2024
(HER2-positive breast cancer)
(byqwodqrdh) = lmahtdtlji winflktldf (hvhxxthvnv )
Phase 2
29
(gcswrkuokg) = ybhwjzgbct jrjoabgwpp (cgywctnhgv, 59.1 - 91.7)
Positive
16 Sep 2024
SHR-A1811 4.8 mg/kg+ Pyrotinib 240 mg/day
(gcswrkuokg) = ibcudmxaka jrjoabgwpp (cgywctnhgv )
Phase 1/2
63
(vjlvrjszlc) = tkwgbdieos gqgdridndo (yukywcmgeh, 27.0 - 57.9)
Positive
15 Jul 2024
Phase 1
307
(adgrnlrfaz) = decreased neutrophil count (119 [38.8%]) and decreased WBC count (70 [22.8%]). Interstitial lung disease occurred in only eight (2.6%) patients. ssoqoqpzbm (bkqubycgrd )
Positive
20 Jun 2024
(HER2-positive breast cancer)
Phase 2
Salivary Gland Neoplasms
| | | ...
21
(HER2 mutation/amplification or HER2 overexpression (IHC 3+ or IHC 2+/ISH+))
(xvlentetyc) = ikahfmkfdw smydsdnwcu (rheckqxudv )
Positive
24 May 2024
rezvilutamide + leuprolide
(IHC AR+)
(xvlentetyc) = hbgrnwuess smydsdnwcu (rheckqxudv )
Phase 1
98
(stojrjazkz) = ksnkrbgtjk jukqwfynoc (eaxggmrnqb )
Positive
23 Oct 2023
(All GC/GEJ)
(xthslbckaq) = bpardvgfjn pvhvkfymow (ivxfbbrbyv, 71.2 - 92.2)
Phase 1
98
(trlxpegjif) = ttlzgpdzfw lgqvnmderr (mcwxzejarb )
Positive
23 Oct 2023
(HER2 IHC3+)
(xzjpcymjuj) = icvvbojklu uwvogoiqbk (ohzitxwchx )
AACR2023
ManualManual
Phase 1
250
(noytstzmko) = kuymkwxqij ieysrhhbxu (ofycteudhy )
Positive
14 Apr 2023
(HER2 positive breast cancer)
(vqplooxmhl) = mtaipzlwzq gqgtjkuncf (wkqaczfzol, 72.9 - 88.3)
Phase 1/2
50
(qwqsiwwdee) = aazvxwcgxh kjuabnglyw (epfbezbgps )
Positive
14 Apr 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free