This study is an open, single-arm, single-center phase II clinical study, which aims to evaluate the efficacy and safety of adebelizumab combined with irinotecan liposome in the second-line treatment of advanced small cell lung cancer, explore biomarkers to predict the efficacy, and further select the dominant population in immunotherapy.
In this study, 46 patients with extensive SCLC who had previously received immunotherapy combined with chemotherapy were enrolled. Subjects who met the enrollment conditions will be given adebelizumab combined with irinotecan liposome at the same time. After 4-6 cycles of treatment, if their condition has not progressed, they will be treated with adebelizumab until the disease progresses, toxicity can not be tolerated or other reasons specified in the scheme can be terminated. Subjects who finish the treatment will enter the follow-up period for safety follow-up and survival follow-up.

Start Date01 Jun 2025

Sponsor / Collaborator-

NCT07007364

/ Not yet recruitingPhase 2IIT

Neoadjuvant Low-Dose Radiotherapy Combined With Adebrelimab and Single-Agent Albumin-Bound Paclitaxel Chemotherapy for Early-Stage Oral Squamous Cell Carcinoma: A Prospective, Single-Arm Clinical Trial

This is a prospective, single-arm, Phase II clinical trial. The included population consisted of untreated patients with histologically confirmed stage I-II oral squamous cell carcinoma. Eligible patients received neoadjuvant low-dose radiotherapy combined with adibelizumab and monotherapy with albumin paclitaxel for two cycles. Radical surgical resection is planned to be carried out 3 to 4 weeks after neoadjuvant therapy. Patients who obtain PCR after evaluation by the researchers after the operation will be maintained for 6 cycles of immunomonotherapy. The primary endpoints were the rate of pathological response and the rate of exemption from cervical lymph node dissection. The secondary endpoints included progression-free survival, local control rate, distant metastasis-free rate, overall survival, safety and quality of life of patients, as well as the exploration of biomarkers

Start Date01 Jun 2025

Sponsor / Collaborator

Hospital of Stomatology Wuhan University

NCT07009457

/ Not yet recruitingPhase 1

An Open Label, Multicenter Phase I Clinical Study on the Pharmacokinetics, Safety, Tolerability, and Efficacy of SHR-1316 (SC) Combined With Carboplatin and Etoposide in First-line Treatment of Extensive Stage Small Cell Lung Cancer

This study is a multicenter, open label phase I clinical trial aimed at evaluating the pharmacokinetics, tolerability, safety and immunogenicity of SHR-1316 (sc) subcutaneous administration combined with carboplatin and etoposide as first-line treatment for extensive stage small cell lung cancer, and to observe the initial anti-tumor efficacy.

Start Date01 Jun 2025

Sponsor / Collaborator

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

100 Clinical Results associated with Adebrelimab

100 Translational Medicine associated with Adebrelimab

100 Patents (Medical) associated with Adebrelimab

Literatures (Medical) associated with Adebrelimab

01 Jun 2025·BMJ Open

Clinical study of adebrelimab in combination with apatinib and irinotecan for PD-1 inhibitor-ineffective advanced-stage gastric cancer: study protocol for a single-arm, single-centre, exploratory trial

Article

Author: Xia, Xiang ; Guan, Yujing ; Bai, Long ; Aimaiti, Muerzhate ; Wang, Shuchang ; Ni, Bo ; Zhang, Hao-Yu ; Yue, Ben ; Gu, Jiayi ; Liu, Tao ; Zhang, Zizhen ; Zhang, Yeqian

Introduction:

Immunotherapy has revolutionised cancer treatment. Immune checkpoint inhibitors have demonstrated significant efficacy across multiple tumour types, including gastric cancer, where several approved programmed cell death 1/programmed cell death-ligand 1 (PD-1/PD-L1) inhibitors show promising antitumour activity. While PD-L1 expression serves as a predictive biomarker for PD-1 inhibitor response, and PD-L1-positive patients generally show better outcomes, therapeutic resistance remains a challenge. Many initial responders eventually develop resistance, and surprisingly, some PD-L1-positive patients fail to achieve expected response rates, indicating emerging resistance mechanisms in potentially responsive populations. Adebrelimab, a PD-L1 inhibitor, demonstrates mechanistic advantages over PD-1 inhibitors, with clinical studies suggesting promising therapeutic potential. When combined with irinotecan, apatinib has shown efficacy in second-line gastric cancer treatment. This study aims to evaluate the efficacy and safety of combining adebrelimab with apatinib and irinotecan for advanced gastric cancer refractory to PD-1 inhibitors.

Method and analysis:

This single-arm, single-centre exploratory trial will be conducted at Renji Hospital, enrolling 32 patients aged 18–75 years. Eligible patients must have initially achieved partial response, complete response or stable disease with progression-free survival (PFS)≥3 months during prior immunotherapy but subsequently progressive disease on imaging. Treatment will continue until meeting discontinuation criteria. The primary endpoint is objective response rate with Clopper-Pearson 95% CI. Secondary endpoints include disease control rate (95% CI), PFS and overall survival (estimated by Kaplan-Meier method), along with safety assessments.

Ethics and dissemination:

All participants will provide informed consent. The protocol has been approved by the Shanghai Jiaotong University School of Medicine, Renji Hospital Ethics Committee (LY2023-201-C). The results will be disseminated through peer-reviewed manuscripts, reports and presentations.

Trial registration number:

ChiCTR2300077329.

01 May 2025·Clinical Lung Cancer

Phase I Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation-Supported Dose-Intensified Chemotherapy With Adebrelimab as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer

Article

Author: Zhou, Chengzhi ; Zhang, Jiexia ; Xie, Zhanhong ; Lin, Xinqing ; Liu, Ming ; Qin, Yinyin ; Xu, Xin ; Guan, Wenhui ; Li, Zekun ; Qiu, Guihuan ; Xie, Xiaohong ; Huang, Zhenqian

BACKGROUND:

Small cell lung cancer (SCLC) is initially highly sensitive to chemotherapy, which often leads to significant tumor reduction. However, the majority of patients eventually develop resistance, and the disease is further complicated by its "cold" tumor microenvironment, characterized by low tumor immunogenicity and limited CD8+ T cell infiltration. These factors contribute to the poor response to immunotherapy in many cases of extensive-stage SCLC (ES-SCLC). High-dose chemotherapy has shown potential in enhancing tumor cytoreduction, but its use is often limited by severe hematologic toxicity. Combining chemotherapy with immune checkpoint inhibitors (ICIs) can create a synergistic effect by promoting immunogenic cell death and enhancing immune activation. Autologous hematopoietic stem cell transplantation (auto-HSCT) provides a means to support hematopoietic recovery, mitigate chemotherapy-induced myelosuppression, and contribute to immune reconstitution. In this context, the integration of auto-HSCT with dose-intensified chemotherapy and ICIs aims to both protect the bone marrow and enhance antitumor immune responses, potentially overcoming resistance to immunotherapy in ES-SCLC.

METHODS:

A phase I, single-center, single-arm trial was designed to evaluate the safety and efficacy of auto-HSCT-supported dose-intensified chemotherapy combined with adebrelimab in treatment-naive ES-SCLC patients. Participants will receive induction chemotherapy followed by stem cell mobilization, apheresis, and cryopreservation. After successful mobilization, consolidation chemotherapy with stem cell reinfusion and granulocyte colony-stimulating factor (G-CSF) support will be performed. Maintenance therapy with adebrelimab continues until disease progression or unacceptable toxicity. Safety and efficacy data, including adverse events, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS), will be analyzed.

RESULTS:

The study aims to enhance treatment outcomes by overcoming resistance to immuno-chemotherapy and promoting immune reconstitution. The trial is ongoing at the First Affiliated Hospital of Guangzhou Medical University.

TRIAL REGISTRATION:

ClinicalTrials.gov Identifier: NCT06597513.

01 Apr 2025·Cancer Communications

A prospective, phase II, neoadjuvant study based on chemotherapy sensitivity in HR+/HER2‐ breast cancer‐FINEST study

Article

Author: Liu, Guang‐Yu ; Li, Jun‐Jie ; Wu, Wen‐Ya ; Liang, Fei ; Wu, Jiong ; Yu, Ke‐Da ; Chen, Li ; Wang, Zhong‐Hua ; Di, Gen‐Hong ; Shao, Zhi‐Ming ; Fan, Lei

Abstract:

Background:

Hormone receptor‐positive (HR+)/humaal growth factor receptor 2‐negative (HER2‐) breast cancer, the most common breast cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median‐high risk HR+/HER2‐ patients. This phase II, single‐arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2‐ breast cancer patients.

Methods:

Eligible female patients with newly diagnosed, untreated HR+/HER2‐ breast cancer received 2 cycles of nab‐paclitaxel and carboplatin (nabPCb). Magnetic resonance imaging (MRI) was performed to assess tumor responses, and 40% regression of the maximal tumor diameter was deemed chemo‐sensitive. Chemo‐sensitive patients continued nabPCb for 4 more cycles (group A). Chemo‐insensitive patients were randomized to groups B, C, and D at a ratio of 1:3:1 to receive a new chemotherapy for 4 cycles or endocrine‐immune‐based therapy (dalpiciclib, letrozole and adebrelimab, with goserelin if patients were premenopausal) for 4 cycles or to undergo surgery. Peripheral blood and core‐needle biopsy (CNB) samples were collected before treatment, followed by a next‐generation sequencing (NGS) panel detection and similarity network fusion (SNF) typing through digital pathology data. The primary endpoint was the pathological complete response (pCR) rate, and the secondary endpoint was the clinical objective response rate (ORR).

Results:

A total of 121 patients were enrolled (67.8% with stage III disease), with 76, 9, 27, and 9 patients in groups A, B, C and D, respectively. The total pCR rate was 4.1%, and all patients who received pCR were in group A. Group C had a better ORR than Group B (81.5% vs. 66.7%). Exploratory analysis revealed that patients with the SNF4 subtype were the most sensitive to nabPCb (pCR rate of 21.1% vs. 1.8% in group A), whereas patients in group C with the SNF2 subtype were more sensitive to endocrine‐immune‐based therapy (Miller‐Payne grade 4‐5, 45.5% vs. 6.3%).

Conclusions:

Converting to endocrine‐immune‐based therapy improved the ORR, but not the pCR rate in chemo‐insensitive patients. Neoadjuvant chemotherapy and endocrine therapy are not mutually exclusive. The SNF4 subtype of HR+/HER2‐ breast cancer was more chemo‐sensitive, whereas the SNF2 subtype might be more sensitive to immunotherapy.

News (Medical) associated with Adebrelimab

05 Jun 2025

·www.prnewswire.com

Hengrui Pharma Showcases Global Impact at the 2025 ASCO: 72 Study Results Highlight Chinese Cancer Innovation

SHANGHAI, June 5, 2025 /PRNewswire/ -- The 2025 ASCO Annual Meeting successfully concluded in Chicago on June 3 (local time). Hengrui Pharma delivered a strong international presence, featuring 15 innovative drugs and 72 research outcomes. These included 4 oral presentations, 5 rapid oral presentations, 27 poster presentations, and 36 online publications. Multiple groundbreaking research advances has elicited widespread discussion among global experts. In the field of breast cancer, results from 19 studies evaluating the company's innovative drugs—pyrotinib, dalpiciclib, camrelizumab, apatinib, adebrelimab, Trastuzumab rezetecan (SHR-A1811), and SHR-2017, either in combination with each other or with chemotherapies, were presented at ASCO 2025. Notably, 7 studies involving pyrotinib and 6 studies involving dalpiciclib were selected, with both agents consistently demonstrating promising efficacy, reinforcing their established roles in breast cancer treatment. Furthermore, studies evaluating SHR-A1811 and adebrelimab were selected for rapid oral presentations, attracting considerable attention from the industry. In the field of gastrointestinal cancers, drugs such as camrelizumab, apatinib, adebrelimab, and SHR-8068 were featured in a total of 30 accepted studies. Notably, camrelizumab was included in 21 of these studies, demonstrating its broad therapeutic profile and potential while reinforcing its position as a key focus at ASCO. This further solidifies the achievements of China-developed PD-1 inhibitors on the global stage. Additionally, adebrelimab, which has achieved significant breakthroughs in lung cancer in recent years, is actively expanding into new indications. At this year's ASCO, five related studies exploring adebrelimab's efficacy in indications such as hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) , and pancreatic cancer were presented. The ongoing emergence of cutting-edge research on both established and emerging agents holds promise for improving clinical outcomes for patients with gastrointestinal tumors. Across a wide range of disease areas—including lung cancer, gynecologic cancers, lymphoma, bladder cancer, head and neck cancer, melanoma, sarcoma, nasopharyngeal carcinoma, chordoma, salivary gland cancer, thymic cancer, desmoid tumors, and salivary duct carcinoma—Hengrui Pharma's innovative oncology portfolio (camrelizumab, apatinib, adebrelimab, pyrotinib, dalpiciclib, fluzoparib, famitinib, SHR-A1811, SHR-1501, SHR-1701, SHR-1826, SHR-A1912, and SHR-A2102) was featured in 22 research presentations at ASCO 2025. These comprised 4 oral presentations, 2 rapid oral presentations, 12 poster presentations, and 4 online publications, collectively demonstrating the company's robust R&D capabilities. Additionally, one online publication highlighted ondansetron oral soluble film, underscoring its favorable efficacy in preventing and treating chemotherapy-induced nausea and vomiting (CINV). For 15 consecutive years, Hengrui Pharma has consistently presented its cutting-edge research at the ASCO Annual Meeting, highlighting the company's global leadership in oncology drug research and development while showcasing China's robust pharmaceutical innovation capabilities to the international academic community. The inclusion of 70 Hengrui-sponsored studies at this year's meeting reflects the strong foundation laid by the company's portfolio of 23 marketed innovative drugs and a robust pipeline of over 90 candidates currently in development. Looking ahead, Hengrui will remain committed to its patient-centric approach, striving to develop advanced therapeutics that support the "Healthy China" initiative and enhance clinical outcomes for patients globally. SOURCE Hengrui Pharma WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

ASCOClinical ResultCSCO

28 Jul 2023

·synapse.patsnap.com

The First Phase 1b Trial Shows Promising Results of Neoadjuvant Adebrelimab for Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinomaThe Chinese Academy of Sciences' Center for Systems Biology recently published a research article in Nature Medicine titled "Neoadjuvant Adebrelimab in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Phase 1b Trial," which reports on the results of the world’s first-ever neoadjuvant mono-immunotherapy Phase 1b clinical trial of locally advanced esophageal squamous cell carcinoma. The study proposes new strategies for predicting tumor immunotherapy efficacy based on multi-omics studies. Neoadjuvant immunotherapyEsophageal cancer is one of the most prevalent malignant tumors of the digestive tract worldwide, with over 90% of cases comprising esophageal squamous cell carcinomas (ESCC), representing nearly 60% of new cases globally. It ranks fourth among common cancers in terms of mortality. Unfortunately, most patients with esophageal cancer are in the locally advanced stage at the time of diagnosis. The current standard clinical treatment methods are neoadjuvant chemoradiotherapy or chemotherapy after surgery. However, these treatments have limited efficacy, leading to local recurrence or distant metastasis and ultimately compromising patient survival rates. Recent years have seen the emergence of immunotherapy, represented by checkpoint inhibitors, which has demonstrated positive therapeutic effects in advanced solid tumors. Its application has gradually extended from second-line maintenance treatment to neoadjuvant treatment. However, the safety and benefits of neoadjuvant mono-immunotherapy for esophageal squamous cell carcinoma have not yet been reported, and there is no clear biological marker for predicting the efficacy of such immunotherapy. To explore the safety and effectiveness of neoadjuvant mono-immunotherapy for patients with locally advanced resectable esophageal squamous cell carcinoma, the researchers carried out a prospective, single-center, single-arm, nonrandomized Phase 1b clinical trial (NATION-1907, registered number NCT04215471). NATION-1907 study design30 patients with stage II-IV resectable esophageal squamous cell carcinoma who underwent surgery after neoadjuvant treatment with Adebrelimab (anti-PD-L1 antibody) were enrolled for the study. Based on assessments of safety and effectiveness, the rate of major pathological response (MPR, tumor shrinkage ≥90%) and overall survival (OS) were elicited. Tumor tissues and blood samples of enrolled patients before and after treatment were collected to integrate genome and transcriptome sequencing, TCR sequencing, and multiple immunofluorescence techniques. The study compared the different molecular characteristics of the sensitive and insensitive groups to explore the potential mechanisms of treatment response and resistance. Safety, efficacy and biomarkersIn the safety evaluation of the study, no adverse reactions over Grade 3 were observed, and 24% of patients achieved major pathological remission (MPR), with 2-year overall survival (OS) at 92% and 2-year disease-free survival (RFS) at 100%. Both treatment adverse reactions and 2-year survival status assessment demonstrated that the neoadjuvant anti-PD-L1 monotherapy adopted in this study was significantly better than neoadjuvant chemotherapy or chemoradiotherapy (compared with CMISG1701 clinical study), showing good safety and efficacy of the treatment regimen. Preliminary efficacyTo compare well responders and poor responders, the research team further analyzed potential biomarkers associated with efficacy stratification. Although no significantly correlated mutation features were identified at the genome variation level, the researchers constructed an "IFN/EMT score" consisting of 12 characteristic genes based on transcriptome data. The score could significantly distinguish patients in different treatment response groups. Further integrative analysis of immune cell composition and enriched cancer-related pathways defined three immune microenvironment phenotypes: immune-enriched, tumor-proliferation, and fibroblast-enriched. Immune-enriched patients exhibited more significant tumor shrinkage compared to the other two types, and the response group had a higher proportion of immune-enriched patients. Immune-enriched TME phenotype in responsive patients.The analysis of non-responsive patients found that their tumors harbored higher densities of immunosuppressive cells such as M2 macrophages and fibroblasts. These patients may require a combination of immune-suppressing strategies to benefit from immunotherapy. Using multiple immunofluorescence staining techniques, the research team further characterized the spatial distribution of the microenvironment in 2 non-responsive patients, classified as immune-excluded and immune-suppressive. In immune-excluded tumors, immune cells accumulated at the tumor margin with limited infiltration into the core, while the immune-suppressive tumor core accumulated more pro-tumor macrophages and fewer B cells. By analyzing the immune repertoire (TCR-seq) of tumor tissues and peripheral blood mononuclear cells (PBMCs), the researchers found that T cell receptor (TCR) diversity in PBMCs and the clonality of tumor-infiltrating T cells (TILs) were positively correlated with treatment response. This suggests that the degree of immune activation in peripheral blood and the infiltration of T cells into the tumor microenvironment may play important roles in predicting the efficacy of immunotherapy. Mechanism of pre-existing T cells in response to neoadjuvant Adebrelimab blockade.The study provides evidence of the safety and effectiveness of neoadjuvant mono-immunotherapy using Adebrelimab in treating locally advanced resectable esophageal squamous cell carcinoma. It also suggests new approaches for predicting the efficacy of tumor immunotherapy through multi-omics studies. The "IFN/EMT score," derived from transcriptome data, immune microenvironment phenotypes, and TCR repertoire analysis, may serve as a potential biomarker for predicting immunotherapy efficacy in patients with esophageal squamous cell carcinoma. These findings establish a foundation for optimizing and personalizing immunotherapy strategies for patients with this type of cancer. Reference: Yin, J., Yuan, J., Li, Y. et al. Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial. Nat Med (2023).

100 Deals associated with Adebrelimab

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB16412

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Extensive stage Small Cell Lung Cancer	China	Shanghai Shengdi Pharmaceutical Co., Ltd.	28 Feb 2023

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Muscle Invasive Bladder Carcinoma	Phase 3	China	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	25 Apr 2025
Advanced Hepatocellular Carcinoma	Phase 3	China	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	28 Oct 2024
Non-squamous non-small cell lung cancer	Phase 3	China	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	29 Mar 2024
Non-squamous non-small cell lung cancer	Phase 3	China	Shanghai Shengdi Pharmaceutical Co., Ltd.	29 Mar 2024
Small cell lung cancer limited stage	Phase 3	China	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	20 Jan 2021
Non-small cell lung cancer stage IIIB	Phase 3	China	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	14 Jul 2020
Resectable Lung Non-Small Cell Carcinoma	Phase 3	China	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	10 Jul 2020
HER2 positive Biliary Tract Neoplasms	Phase 2	China	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	26 Feb 2025
Cirrhosis, Familial, With Pulmonary Hypertension	Phase 2	China	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	22 Jan 2025
Unresectable Intrahepatic Cholangiocarcinoma	Phase 2	China	Jiangsu Hengrui Pharmaceuticals Co., Ltd.	22 Jan 2025

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04303988 (ASCO2025) Manual	Phase 2	Triple Negative Breast Cancer	35	Adebrelimab + Bevacizumab + Cisplatin/Carboplatin	ydtozxxchp(djwljvqbrf) = iqdcrukmxd bzvynabuxl (iaztaeemgs ) View more	Positive	30 May 2025
NCT06016413 (Phase II study of adebrelimab plus carboplatin and albumin-bound taxanol in head and neck squamous cell carcinoma, ASCO2025)	Phase 2	Locally Advanced Head and Neck Squamous Cell Carcinoma Neoadjuvant PD-L1	30	Adebrelimab + Carboplatin + Albumin-bound Paclitaxel	sqtnfxwodo(siarmlvavs) = acrrzdsdsn zwpzwegsad (claizqjixc ) View more	Positive	30 May 2025
CAPSTONE-1 (ESMO_ELCC2025)	Not Applicable	Extensive stage Small Cell Lung Cancer	75	Adebrelimab-based therapy	imjrlpoxkk(oqormcpylp) = fpmpkiayiz xjbrljvsab (vbelabqiuk, 54.8 - 77.1) View more	Positive	26 Mar 2025
NCT06299371 (ESMO_ELCC2025)	Phase 2	EGFR-mutated non-small Cell Lung Cancer Neoadjuvant \| Adjuvant EGFR mutations	-	Adebrelimab + Albumin-bound paclitaxel + Carboplatin/Cisplatin	dbuqwfzwqo(opowrlplux) = xhsmyftnir zgpgfsdwdj (znddgndasa ) View more	-	26 Mar 2025
NCT06178211 (ASCO_GI2025) Manual	Phase 2	Locally Advanced Esophageal Squamous Cell Carcinoma Neoadjuvant	36	Adebrelimab + Chemotherapy	dtlskcymft(tucrvpecif) = mungezebij tiifjhqbcl (dacnevllyq, 23.1 - 56.5) View more	Positive	23 Jan 2025
NCT06178211 (ASCO_GI2025) Manual	Phase 2		36	Adebrelimab + Chemotherapy (Surgery)	dtlskcymft(tucrvpecif) = ybrnkuemmg tiifjhqbcl (dacnevllyq, 24.6 - 59.3) View more	Positive	23 Jan 2025
ChiCTR2300069179 (ASCO_GI2025) Manual	Phase 2	Locally Advanced Esophageal Squamous Cell Carcinoma Adjuvant \| Neoadjuvant	36	Adebrelimab + Paclitaxel + Cisplatin	ymfflyowla(ysbzhkirml) = eqvyzpeasd ddadegumyi (wrkrhhxywl ) View more	Positive	23 Jan 2025
NCT06198465 (ESMO_IO2024) Manual	Phase 2	Gastroesophageal junction adenocarcinoma Neoadjuvant	15	Adebrelimab + nab-paclitaxel + lobaplatin + S-1	jaabobvffd(butnosldzf) = fmtlndvfry ukwzkamulv (xzechpphrs ) View more	Positive	12 Dec 2024
ESMO_IO2024 Manual	Not Applicable	Extensive stage Small Cell Lung Cancer First line	188	Adebrelimab-based regimen	oupusxszvr(qsuwamgvdl) = szkrychazc vpxvxkhehz (znuyhtrqmc ) View more	Positive	12 Dec 2024
ADBL-LC-001 (ESMO_IO2024) Manual	Not Applicable	Small Cell Lung Cancer First line	143	Adebrelimab (ES-SCLC)	mfzgcibytl(uuuesjdrvh) = dcsjuvsjtz gangowllsr (zldbnphccs, 10.0 - 14.9) View more	Positive	12 Dec 2024
ADBL-LC-001 (ESMO_IO2024) Manual	Not Applicable	Small Cell Lung Cancer First line	143	Adebrelimab (LS-SCLC)	mfzgcibytl(uuuesjdrvh) = kqzeepqnpb gangowllsr (zldbnphccs, 13.7 - NA) View more	Positive	12 Dec 2024
NCT04562337 (Pubmed \| EClinicalMedicine) Manual	Phase 2	Extensive stage Small Cell Lung Cancer First line	67	Adebrelimab + EP/EC chemotherapy	nhmcfmlxpm(ddspubibkb) = sayzdjwbdv bpgypxxuld (lwprmjydjm, 17.2 - NR) View more	Positive	01 Sep 2024

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