Adebrelimab

SHANGHAI, June 5, 2025 /PRNewswire/ -- The 2025 ASCO Annual Meeting successfully concluded in Chicago on June 3 (local time). Hengrui Pharma delivered a strong international presence, featuring 15 innovative drugs and 72 research outcomes. These included 4 oral presentations, 5 rapid oral presentations, 27 poster presentations, and 36 online publications. Multiple groundbreaking research advances has elicited widespread discussion among global experts. In the field of breast cancer, results from 19 studies evaluating the company's innovative drugs—pyrotinib, dalpiciclib, camrelizumab, apatinib, adebrelimab, Trastuzumab rezetecan (SHR-A1811), and SHR-2017, either in combination with each other or with chemotherapies, were presented at ASCO 2025. Notably, 7 studies involving pyrotinib and 6 studies involving dalpiciclib were selected, with both agents consistently demonstrating promising efficacy, reinforcing their established roles in breast cancer treatment. Furthermore, studies evaluating SHR-A1811 and adebrelimab were selected for rapid oral presentations, attracting considerable attention from the industry. In the field of gastrointestinal cancers, drugs such as camrelizumab, apatinib, adebrelimab, and SHR-8068 were featured in a total of 30 accepted studies. Notably, camrelizumab was included in 21 of these studies, demonstrating its broad therapeutic profile and potential while reinforcing its position as a key focus at ASCO. This further solidifies the achievements of China-developed PD-1 inhibitors on the global stage. Additionally, adebrelimab, which has achieved significant breakthroughs in lung cancer in recent years, is actively expanding into new indications. At this year's ASCO, five related studies exploring adebrelimab's efficacy in indications such as hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) , and pancreatic cancer were presented. The ongoing emergence of cutting-edge research on both established and emerging agents holds promise for improving clinical outcomes for patients with gastrointestinal tumors. Across a wide range of disease areas—including lung cancer, gynecologic cancers, lymphoma, bladder cancer, head and neck cancer, melanoma, sarcoma, nasopharyngeal carcinoma, chordoma, salivary gland cancer, thymic cancer, desmoid tumors, and salivary duct carcinoma—Hengrui Pharma's innovative oncology portfolio (camrelizumab, apatinib, adebrelimab, pyrotinib, dalpiciclib, fluzoparib, famitinib, SHR-A1811, SHR-1501, SHR-1701, SHR-1826, SHR-A1912, and SHR-A2102) was featured in 22 research presentations at ASCO 2025. These comprised 4 oral presentations, 2 rapid oral presentations, 12 poster presentations, and 4 online publications, collectively demonstrating the company's robust R&D capabilities. Additionally, one online publication highlighted ondansetron oral soluble film, underscoring its favorable efficacy in preventing and treating chemotherapy-induced nausea and vomiting (CINV). For 15 consecutive years, Hengrui Pharma has consistently presented its cutting-edge research at the ASCO Annual Meeting, highlighting the company's global leadership in oncology drug research and development while showcasing China's robust pharmaceutical innovation capabilities to the international academic community. The inclusion of 70 Hengrui-sponsored studies at this year's meeting reflects the strong foundation laid by the company's portfolio of 23 marketed innovative drugs and a robust pipeline of over 90 candidates currently in development. Looking ahead, Hengrui will remain committed to its patient-centric approach, striving to develop advanced therapeutics that support the "Healthy China" initiative and enhance clinical outcomes for patients globally. SOURCE Hengrui Pharma WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Esophageal squamous cell carcinomaThe Chinese Academy of Sciences' Center for Systems Biology recently published a research article in Nature Medicine titled "Neoadjuvant Adebrelimab in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Phase 1b Trial," which reports on the results of the world’s first-ever neoadjuvant mono-immunotherapy Phase 1b clinical trial of locally advanced esophageal squamous cell carcinoma. The study proposes new strategies for predicting tumor immunotherapy efficacy based on multi-omics studies. Neoadjuvant immunotherapyEsophageal cancer is one of the most prevalent malignant tumors of the digestive tract worldwide, with over 90% of cases comprising esophageal squamous cell carcinomas (ESCC), representing nearly 60% of new cases globally. It ranks fourth among common cancers in terms of mortality. Unfortunately, most patients with esophageal cancer are in the locally advanced stage at the time of diagnosis. The current standard clinical treatment methods are neoadjuvant chemoradiotherapy or chemotherapy after surgery. However, these treatments have limited efficacy, leading to local recurrence or distant metastasis and ultimately compromising patient survival rates.  Recent years have seen the emergence of immunotherapy, represented by checkpoint inhibitors, which has demonstrated positive therapeutic effects in advanced solid tumors. Its application has gradually extended from second-line maintenance treatment to neoadjuvant treatment. However, the safety and benefits of neoadjuvant mono-immunotherapy for esophageal squamous cell carcinoma have not yet been reported, and there is no clear biological marker for predicting the efficacy of such immunotherapy. To explore the safety and effectiveness of neoadjuvant mono-immunotherapy for patients with locally advanced resectable esophageal squamous cell carcinoma, the researchers carried out a prospective, single-center, single-arm, nonrandomized Phase 1b clinical trial (NATION-1907, registered number NCT04215471). NATION-1907 study design30 patients with stage II-IV resectable esophageal squamous cell carcinoma who underwent surgery after neoadjuvant treatment with Adebrelimab (anti-PD-L1 antibody) were enrolled for the study. Based on assessments of safety and effectiveness, the rate of major pathological response (MPR, tumor shrinkage ≥90%) and overall survival (OS) were elicited. Tumor tissues and blood samples of enrolled patients before and after treatment were collected to integrate genome and transcriptome sequencing, TCR sequencing, and multiple immunofluorescence techniques. The study compared the different molecular characteristics of the sensitive and insensitive groups to explore the potential mechanisms of treatment response and resistance.  Safety, efficacy and biomarkersIn the safety evaluation of the study, no adverse reactions over Grade 3 were observed, and 24% of patients achieved major pathological remission (MPR), with 2-year overall survival (OS) at 92% and 2-year disease-free survival (RFS) at 100%. Both treatment adverse reactions and 2-year survival status assessment demonstrated that the neoadjuvant anti-PD-L1 monotherapy adopted in this study was significantly better than neoadjuvant chemotherapy or chemoradiotherapy (compared with CMISG1701 clinical study), showing good safety and efficacy of the treatment regimen. Preliminary efficacyTo compare well responders and poor responders, the research team further analyzed potential biomarkers associated with efficacy stratification. Although no significantly correlated mutation features were identified at the genome variation level, the researchers constructed an "IFN/EMT score" consisting of 12 characteristic genes based on transcriptome data. The score could significantly distinguish patients in different treatment response groups. Further integrative analysis of immune cell composition and enriched cancer-related pathways defined three immune microenvironment phenotypes: immune-enriched, tumor-proliferation, and fibroblast-enriched. Immune-enriched patients exhibited more significant tumor shrinkage compared to the other two types, and the response group had a higher proportion of immune-enriched patients. Immune-enriched TME phenotype in responsive patients.The analysis of non-responsive patients found that their tumors harbored higher densities of immunosuppressive cells such as M2 macrophages and fibroblasts. These patients may require a combination of immune-suppressing strategies to benefit from immunotherapy. Using multiple immunofluorescence staining techniques, the research team further characterized the spatial distribution of the microenvironment in 2 non-responsive patients, classified as immune-excluded and immune-suppressive. In immune-excluded tumors, immune cells accumulated at the tumor margin with limited infiltration into the core, while the immune-suppressive tumor core accumulated more pro-tumor macrophages and fewer B cells. By analyzing the immune repertoire (TCR-seq) of tumor tissues and peripheral blood mononuclear cells (PBMCs), the researchers found that T cell receptor (TCR) diversity in PBMCs and the clonality of tumor-infiltrating T cells (TILs) were positively correlated with treatment response. This suggests that the degree of immune activation in peripheral blood and the infiltration of T cells into the tumor microenvironment may play important roles in predicting the efficacy of immunotherapy. Mechanism of pre-existing T cells in response to neoadjuvant Adebrelimab blockade.The study provides evidence of the safety and effectiveness of neoadjuvant mono-immunotherapy using Adebrelimab in treating locally advanced resectable esophageal squamous cell carcinoma. It also suggests new approaches for predicting the efficacy of tumor immunotherapy through multi-omics studies. The "IFN/EMT score," derived from transcriptome data, immune microenvironment phenotypes, and TCR repertoire analysis, may serve as a potential biomarker for predicting immunotherapy efficacy in patients with esophageal squamous cell carcinoma. These findings establish a foundation for optimizing and personalizing immunotherapy strategies for patients with this type of cancer. Reference: Yin, J., Yuan, J., Li, Y. et al. Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial. Nat Med (2023).