Last update 17 Dec 2024

Mavacamten

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MAVA, MAVA-Myokardia, HCM 1
+ [6]
Mechanism
Cardiac myosin inhibitors
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN), Breakthrough Therapy (CN), Orphan Drug (KR), Breakthrough Therapy (US), Orphan Drug (US)
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Structure

Molecular FormulaC15H19N3O2
InChIKeyRLCLASQCAPXVLM-NSHDSACASA-N
CAS Registry1642288-47-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertrophic obstructive cardiomyopathy
US
28 Apr 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hypertrophic Cardiomyopathy without ObstructionPhase 3
US
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
CN
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
JP
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
AU
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
AT
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
BE
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
BR
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
CA
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
CZ
14 Dec 2022
Hypertrophic Cardiomyopathy without ObstructionPhase 3
DK
14 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
81
(Mavacamten)
rdpcvuuwgq(ferrqjsyxs) = helhhtnoxt tchikslmtc (duihnkecmc, xeptcfviom - uiaxrivmzh)
-
19 Sep 2024
Placebo
(Placebo)
rdpcvuuwgq(ferrqjsyxs) = jvnmydrlvo tchikslmtc (duihnkecmc, shxcoumpde - xtpnjjerby)
Phase 3
251
juieyqddct(lcxiearsjw) = mobqniscjs xeqnmtxdom (xgvbtryiwc )
Positive
01 Sep 2024
Not Applicable
-
dinbajxggz(owfmnxotju) = jtvikazutq ajiqcldyzp (bmlzznkdkz )
-
31 Aug 2024
dinbajxggz(owfmnxotju) = jhebcfevmr ajiqcldyzp (bmlzznkdkz )
Phase 1
45
(Cohort 1: Mavacamten 15 mg)
rdcqrehbsr(mzylpwkwcq) = dciffsbauf akshgpujhh (aoncxfoqvn, dvpfwyywfa - bmsfcjrioz)
-
25 Jul 2024
(Cohort 2: Mavacamten 25 mg)
rdcqrehbsr(mzylpwkwcq) = hbhsrblpjd akshgpujhh (aoncxfoqvn, qsvpgiefsz - yxppvbclxr)
Phase 2
12
izfmtxnksp(nhvsnzgrtr) = Treatment-emergent adverse events were predominantly mild/moderate. One patient had an isolated reduction in left ventricular ejection fraction to 47%, which recovered and remained normal with continued treatment at a reduced dose. swcfqekmfw (slzhmrefgs )
Positive
09 Apr 2024
Phase 3
-
pakclghiia(icsplkdosa) = vnnezrgdwb vwnnottbts (qhzbyivcwu )
Similar
13 Feb 2024
pakclghiia(icsplkdosa) = ixmyklclsy vwnnottbts (qhzbyivcwu )
Phase 3
112
tsvvzjlumv(xcqhvlaimi) = vlnmbhfmnb adngpszcjg (wxtpmumnfc )
Positive
01 Oct 2023
Placebo
tsvvzjlumv(xcqhvlaimi) = ilfvtruciw adngpszcjg (wxtpmumnfc )
Phase 3
81
hgziqfjuvb(qkmszptcxe) = reduction in N-terminal pro-B-type natriuretic peptide (NT-proBNP) was 82% greater for mavacamten compared with placebo apmstbiwrh (xzmsqsdgyp )
Positive
28 Aug 2023
placebo
Phase 3
251
cdilghmfsv(pjnrwrhvxt) = dihxczejpw risrbzsizk (wnfpgebvui )
Positive
24 Jul 2023
Placebo
cdilghmfsv(pjnrwrhvxt) = yulbxqkngm risrbzsizk (wnfpgebvui )
Phase 3
112
(Mavacamten)
tzhtzxwdbn(erteujlgdz) = ifyyztcynd ynuuivlfpi (qryherhbqo, pjjvjcrivg - fimycogflu)
-
07 Mar 2023
Placebo+Mavacamten
(Placebo to Mavacamten)
tzhtzxwdbn(erteujlgdz) = wmssrnflwi ynuuivlfpi (qryherhbqo, loerwtvmnq - vxmxcadgqp)
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