[Translation] A multicenter, randomized, double-blind, placebo-controlled phase II clinical trial evaluating the efficacy and safety of GT20029 tincture in the treatment of Chinese adult males with androgenetic alopecia (AGA)

主要目的：评价GT20029酊治疗中国成年男性雄激素性秃发（AGA）的有效性和安全性，并确定III期试验推荐给药剂量。次要目的: 评价GT20029酊治疗中国成年男性雄激素性秃发（AGA）患者中的药代动力学特征。

[Translation]

main purpose: To evaluate the efficacy and safety of GT20029 tincture in the treatment of male androgenetic alopecia (AGA) in Chinese adults, and to determine the recommended dosage for phase III trials. Secondary purpose: To evaluate the pharmacokinetic characteristics of GT20029 tincture in Chinese adult male patients with androgenetic alopecia (AGA).

Start Date13 Apr 2023

Sponsor / Collaborator

Suzhou Kintor Pharmaceuticals, Inc.

NCT05428449 / CompletedPhase 1

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose Escalation Study in Subjects to Evaluate the Safety, Tolerability and Pharmacokinetics of GT20029 Following Topical Single and Multiple Ascending Dose Administration

A randomized, double-blind, placebo-controlled, parallel group, dose escalation study to evaluate the safety, tolerability and pharmacokinetics (PK) of GT20029 following topical single ascending dose in healthy subjects and multiple ascending dose administration in subjects with androgenetic alopecia(AGA) or acne

Start Date10 Feb 2022

Sponsor / Collaborator

Suzhou Kintor Pharmaceuticals, Inc.

CTR20211363 / CompletedPhase 1

评价GT20029凝胶/酊在健康受试者中单、多剂外用给药的安全性、药代动力学特征的随机、双盲、安慰剂对照的I期临床试验

[Translation] A randomized, double-blind, placebo-controlled phase I clinical trial to evaluate the safety and pharmacokinetics of GT20029 gel/tincture in single and multiple topical administrations in healthy subjects

主要目的（1）评价GT20029凝胶在健康受试者中单剂及多剂局部外用给药的安全性，确定II期推荐给药剂量（RP2D）。（2）评价GT20029酊在健康受试者中多剂局部外用给药的安全性，确定II期推荐给药剂量（RP2D）。次要目的（1）评价GT20029凝胶在健康受试者中单剂及多剂局部外用给药的药代动力学（PK）特征。（2）评价GT20029酊在健康受试者中多剂局部外用给药的药代动力学（PK）特征。（3）以GT20029凝胶为参照，评价凝胶剂和酊剂的系统暴露量比例。

[Translation]

main purpose (1) To evaluate the safety of single-dose and multiple-dose topical administration of GT20029 gel in healthy subjects, and to determine the recommended dosage for Phase II (RP2D). (2) To evaluate the safety of multi-dose topical administration of GT20029 tincture in healthy subjects, and to determine the phase II recommended dose (RP2D). secondary purpose (1) To evaluate the pharmacokinetic (PK) characteristics of GT20029 gel in healthy subjects with single-dose and multiple-dose topical administration. (2) To evaluate the pharmacokinetic (PK) characteristics of GT20029 tincture in healthy subjects with multiple doses of topical administration. (3) Using GT20029 gel as a reference, evaluate the systemic exposure ratio of gel and tincture.

Start Date25 Jul 2021

Sponsor / Collaborator

Suzhou Kintor Pharmaceuticals, Inc.

100 Clinical Results associated with GT-20029

100 Translational Medicine associated with GT-20029

100 Patents (Medical) associated with GT-20029

Literatures (Medical) associated with GT-20029

24 Aug 2023·Journal of medicinal chemistryQ1 · MEDICINE

Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer.

Q1 · MEDICINE

Article

Author: Hu, Xiaolin ; Wang, Xiao ; Mao, Mei ; Yang, Zhenqian ; Zhang, Sai ; Zhang, Bowen ; Qin, Chong ; Zhang, Siqi ; Liu, Chang ; Ma, Shumin ; Li, Zhuoyue ; Li, Baohu

We report small molecular PROTAC compounds targeting the androgen receptor N-terminal domain (AR-NTD), which were obtained by tethering AR-NTD antagonists and different classes of E3 ligase ligands through chemical linkers. A representative compound, BWA-522, effectively induces degradation of both AR-FL and AR-V7 and is more potent than the corresponding antagonist against prostate cancer (PC) cells in vitro. We have shown that the degradation of AR-FL and AR-V7 proteins by BWA-522 can suppress the expression of AR downstream proteins and induce PC cell apoptosis. BWA-522 achieves 40.5% oral bioavailability in mice and 69.3% in beagle dogs. In a LNCaP xenograft model study, BWA-522 was also proved to be an efficacious PROTAC degrader, resulting in 76% tumor growth inhibition after oral administration of a dose of 60 mg/kg. This study indicates that BWA-522 is a promising AR-NTD PROTAC for the treatment of AR-FL- and AR-V7-dependent tumors.

01 Jan 2023·American Journal of Clinical Dermatology

What’s New in Therapy for Male Androgenetic Alopecia?

Article

Author: Grimalt, Ramon ; Saceda-Corralo, David ; Domínguez-Santas, Miguel ; Vañó-Galván, Sergio

Male androgenetic alopecia is a common condition and represents a major concern for patients who experience this condition. While there are different treatments to stop hair loss and improve hair density, the 5-alpha reductase inhibitors have demonstrated to be effective in improving androgenetic alopecia in men and can maintain a positive response for many years. Oral finasteride 1 mg is a US FDA-approved option, but dutasteride 0.5 mg has been proven to induce better responses, especially in the frontal area. Both have been shown to be safe in clinical trials but there is widespread concern about sexual adverse effects among patients. The use of topical finasteride has increased during the last few years as a useful option to avoid systemic therapy. The efficacy of topical finasteride 0.25% daily has been demonstrated in clinical trials, with a less marked decrease in serum dihydrotestosterone levels than with oral intake. Mesotherapy with dutasteride has also become more widespread recently, although evidence of its effectiveness is limited to retrospective studies in real clinical practice. The use of oral minoxidil in androgenetic alopecia has not been approved by the FDA, however several clinical studies have shown that it is an effective treatment option. The initial dose recommended to treat male hair loss is 2.5 mg daily, although the dose is frequently increased to 5 mg daily. The main adverse effect of oral minoxidil is hypertrichosis, followed by dizziness or lower limb edema, which are much less common. Platelet-rich plasma is a non-pharmacological option to treat male androgenetic alopecia, with some clinical trials demonstrating an improvement in hair count after several months. Among the published studies, the main limitation to compare its efficacy is the heterogeneity of the procedure. The most frequent regimens propose treatment every 4 weeks for 3 months initially to assess the individual response. Another treatment alternative is the use of light devices with wavelengths of between 630 and 660 nm, known as low-level laser therapy. These devices can be used at home every day for 15-30 min. Their efficacy has been shown in a limited number of clinical trials; however, there is a lack of evidence about the efficacy of these devices compared with other medical options or as a complementary therapy in hair loss. The pipeline of potential new treatments for male androgenetic alopecia is strong. Pyrilutamide and GT20029 are being studied as topical antagonists of the androgen receptor, while cetirizine is another topical option with some initial promising results. Furthermore, according to isolated studies with heterogeneous treatment schemes, the use of botulinum toxin in the scalp might improve androgenetic alopecia, and lastly, scalp threading might increase the total hair count as growth factors are released during implantation.

01 Oct 2022·Advanced Science

De Novo Design of an Androgen Receptor DNA Binding Domain‐Targeted peptide PROTAC for Prostate Cancer Therapy

Article

Author: Wang, Zixi ; Wei, Yi ; Chen, Yule ; Fan, Yizeng ; Jian, Yanlin ; Li, Lei ; Liu, Donghua ; Xu, Shan ; Ma, Jian ; Ma, Bohan ; Zhang, Dize ; Gao, Yang

Abstract:

Androgen receptor splice variant‐7 (AR‐V7), one of the major driving factors, is the most attractive drug target in castration‐resistant prostate cancer (CRPC). Currently, no available drugs efficiently target AR‐V7 in clinical practice. The DNA binding domain (DBD) is indispensable for the transcriptional activity of AR full length and AR splice variants, including AR‐V7. Based on the homodimerization structure of the AR DBD, a novel peptide‐based proteolysis‐targeting chimera (PROTAC) drug is designed to induce AR and AR‐V7 degradation in a DBD and MDM2‐dependent manner, without showing any activity on other hormone receptors. To overcome the short half‐life and poor cell penetrability of peptide PROTAC drugs, an ultrasmall gold (Au)‐peptide complex platform to deliver the AR DBD PROTAC in vivo is developed. The obtained Au‐AR pep‐PROTAC effectively degrades AR and AR‐V7 in prostate cancer cell lines, particularly in CWR22Rv1 cells with DC50 values 48.8 and 79.2 nM, respectively. Au‐AR pep‐PROTAC results in suppression of AR levels and induces tumor regression in both enzalutamide sensitive and resistant prostate cancer animal models. Further optimization of the Au‐AR pep‐PROTAC can ultimately lead to a new therapy for AR‐V7‐positive CRPC.

News (Medical) associated with GT-20029

22 Aug 2023

·www.prnewswire.com

Kintor Pharma Announces Completion of Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China

SUZHOU, China, Aug. 22, 2023 /PRNewswire/ -- Kintor Pharmaceutical Limited ("Kintor Pharma", HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecules and biological therapeutics, announced that the company has completed the enrollment of 180 patients for the Phase II clinical trial of its in-house developed first-in-class proteolysis targeting chimera (PROTAC) compound GT20029 in China for the treatment of male androgenetic alopecia (AGA). GT20029 was developed based on the in-house PROTAC platform and is the world's first topical PROTAC compound which has entered the Phase II clinical stage. The Phase II clinical trial is a multi-center, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of GT20029 for treating male AGA patients in China, and to determine the recommended dosage for the Phase III clinical trial. This trial involves a total of 12 clinical research centers in China, and Professor Yang Qinping from Fudan University Huashan Hospital is the leading principal investigator (leading PI). The primary endpoint of this trial is the change from baseline in non-vellus target area hair counts (TAHC) after 12 weeks of treatment in comparison to placebo. Previously, Kintor Pharma has completed the Phase I clinical trials of GT20029 both in China and the US, and the top-line data of more than 200 subjects has demonstrated that GT20029 has a good safety profile and is well-tolerated for single and multiple doses of topical application. Dr. Youzhi Tong, founder, Chairman and Chief Executive Officer of Kintor Pharma, commented, "We would like to thank all the PIs from the centers and the company's medical and clinical operation staffs for their joint efforts to finish the patients enrollment in the Phase II clinical trial of GT20029 in about four months. We expect to release the top-line data of the Phase II clinical trial in the first quarter of 2024, and look forward to collecting more efficacy and safety data of GT20029 in this trial. " About Kintor Pharmaceutical Limited Kintor Pharmaceutical Limited is developing and commercializing a robust pipeline of innovative small molecule and biological therapeutics for oncology and androgen-receptor-related disease areas with unmet medical needs, including alopecia, acne, COVID-19, prostate cancer, liver and breast cancers. For more information, visit . SOURCE Kintor Pharma

Phase 2Phase 1

30 Mar 2023

·www.biospace.com

Kintor Pharma Announces 2022 Annual Results and Recent Business Progress

SUZHOU, China, March 30, 2023 /PRNewswire/ -- Kintor Pharmaceutical Limited (Kintor Pharma, HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecules and biological therapeutics, today announced business highlights and financial results for the year ended 31 December 2022. Business Highlights Kintor Pharma has made rapid progress on global clinical development, and achieved positive data read-outs of core products during the reporting period. Kintor Pharma has rolled out the clinical pipeline in dermatology area globally. Kintor Pharma is actively promoting the business development opportunities in China and globally to accelerate the commercialization progress. Kintor Pharma has raised about $100 million through 2 top-up placements during the reporting period. The company's stock has been included in MSCI China Index and Shanghai-Hong Kong Stock Connect, which increased the stock's liquidity in the capital market. The company's R&D outcome has been accepted by reputable academic conferences including AACR, ASH and AAD of the U.S., which has demonstrated its R&D capabilities. Dr. Youzhi Tong, founder, Chairman, and CEO of Kintor Pharma, commented, 2022 has been a challenging year for the global biotech industry. Under the difficulty market conditions, Kintor Pharma has made rapid progress in R&D, financing and academic publications. In terms of R&D, the company has made steady progress in its pipeline and achieved positive data read-outs of its core products, including Pyrilutamide (KX-826) for androgenetic alopecia (AGA) indication, GT20029 for AGA and acne vulgaris indications. The Phase II clinical trials of KX-826 for male and female AGA in China have reached the primary endpoints, respectively. Kintor Pharma has rolled out the clinical pipeline in dermatology area globally, and is actively promoting the business development opportunities in China and globally to accelerate the commercialization progress. In capital market, the company has raised net proceeds of $100 million through two top-up placements during the reporting period. In addition, the company's stock has been included in the MSCI China Index and the Shanghai-Hong Kong Stock Connect, further enhanced the stock's liquidity in the capital market. In academics, the company's research results have been presented at important academic conferences such as AACR, ASH and AAD of the U.S., proving that the company's innovation ability and its international influence. Looking forward, Kintor Pharma will continue to execute the development of the core products in China and globally, expecting to accelerate its commercialization process. The company strives to bring safe and effective therapeutics to the patients around the globe, and create value for its shareholders and employees. Rapid Progress on Global Clinical Development and Positive Data Read-outs of Core Products As a Biotech company focusing on the R&D and industrialization of potential First-in-Class and Best-in-Class innovative drugs, Kintor Pharma has developed a diversified product pipeline including small-molecule drugs, biologics innovative drugs and combination therapies. At present, the company has seven novel drug candidates with First-in-Class or Best-in-Class potential in Phase I-III clinical stages in China and around the world. Since 2022, the company has released positive clinical results of core products, including the Phase II clinical trials of KX-826 for male and female AGA in China, respectively, and the Phase I clinical trials of GT20029 for the treatment of AGA and ance in both China and the U.S.. Pyrilutamide (KX-826) is a topical androgen receptor (AR) antagonist that is under clinical development for the potential treatment of AGA and acne. KX-826 is the world's first AR antagonist for AGA treatment which entered the Phase III clinical trial stage. On 27 August 2022, one of the leading principal investigators of the Phase II clinical trial of KX-826 in China for the treatment of male AGA adults, Professor Jianzhong Zhang (张建中) from Peking University People's Hospital, released the trial's positive results at the 6th Annual Meeting of Chinese Hair Research Society (第六届全国毛发学术会议). The results showed that after 24 weeks of treatment, the non-vellus target area hair counts (TAHC) in the 5mg (0.5% concentration) twice daily (BID) KX-826 group increased by 15.34/cm2 compared with the placebo group from baseline, with a statistical difference (P=0.024). On 1 December 2022, the company announced that the primary endpoint of Phase II clinical trial of KX-826 for female AGA adults in China was met. After 24 weeks of treatment, the non-vellus TAHC in the 5mg (0.5% concentration) once daily (QD) KX-826 group increased by 11.39/cm2 compared with the placebo group from baseline, with a statistical difference (P=0.0087). KX-826 has showed a good safety pro both trials. GT20029 is a topical AR-Proteolysis Targeting Chimera (PROTAC) compound that is under clinical development for the potential treatment of AGA and acne. GT20029 is the world's first topical PROTAC compound which entered the clinical stage. On 24 November 2022, the company announced the top-line data of the Phase I clinical trial of GT20029 for the treatment of AGA and acne in China. The results showed that GT20029 demonstrated good safety, tolerability and pharmacokinetics in healthy subjects. On 10 February 2023, the company announced the top-line data of the Phase I clinical trial of GT20029 for the treatment of AGA and acne in the U.S.. The results showed that GT20029 demonstrated good safety, tolerability and pharmacokinetics following topical single ascending dose (SAD) administration in healthy subjects and multiple ascending dose (MAD) administration in subjects with AGA or acne. In addition, the company's product pipeline includes Pruxelutamide, GT1708F, GT0486, ALK-1 antibody (GT90001) and GT90008 in the clinical stage, and c-Myc inhibitor, compound of other targets out of PROTAC platform and ALK-1/VEGF bispecific antibody in the preclinical stage. The company's Hedgehog/SMO inhibitor GT1708F is being explored for both idiopathic pulmonary fibrosis (IPF) indication and combination therapy in blood cancer. The company is now preparing for clinical trial application for the IPF indication. The Growing Visibility in the Capital Market Since its listing on the Hong Kong Stock Exchange on 22 May 2020, the company's development has received long-term support from investors around the world. In 2022, the company successfully completed two top-up placements in the capital market and raised about $100 million. After being included in the Hong Kong Stock Connect program in September 2021, the company's stock has been included in the Shanghai-Hong Kong Stock Connect in March 2023, further expanding the company's mainland investor pool, improving its liquidity and the market influence. Thus benefits the company's future development prospects. In addition, Kintor Pharma's stock have been included in the MSCI China Index during the reporting period. Increasing Presence in Reputable Academic Seminars and Conferences Since 2022, Kintor Pharma's R&D outcome has been accepted by reputable academic conferences and journals, proving that the company's innovation ability and its international influence, and further demonstrating the First-in-Class and Best-in-Class potential of the company's product pipeline. Kintor Pharma's KX-826 and GT20029 for treatment of AGA and acne presented at AAD 2023 Kintor Pharma's Hedgehog/SMO inhibitor GT1708F for the treatment of Acute Myeloid Leukemia (AML) presented at AACR 2023 Oral Presentation highlighting the data from novel dual c-Myc/GSPT1 degrader GT19715 at ASH 2022 Pruxelutamide for treatment of COVID-19 and a c-Myc degrader for treatment of blood cancer and small cell lung cancers (SCLC) presented at AACR 2022 The study result of GT19715, a novel dual-target degrader of C-Myc/GSPT1, was published in the journal Clinical Lymphoma, Myeloma & Leukemia The study result of the Phase Ib clinical trial of Pruxelutamide for treatment of breast Cancer was published in the European Journal of Cancer (EJC) Industry and Capital Market Awards Kintor Pharma's persistent efforts in R&D has been widely recognized in the industry and has won many industry and capital market awards. Top 15 Biotech of the Top 100 Hong Kong Listed Companies Top 10 Innovative Pharmaceutical Companies in 2022 R&D Innovation Outstanding Contribution Award in 2021 Top 20 Biomedical Innovation Potential List in 2022 TOP 30 Innovative Small Molecule Pharmaceutical Companies in China in 2021 TOP 20 Most Influential Small Molecule Pharmaceutical Innovation Companies in 2022 Jishi Cup Top 10 Pharmaceutical Innovation Companies in 2021 Most Valuable Pharmaceutical and Medical Companies Other Business Updates In August 2022, Dr. Lu Qun, our Chief Technology Officer, was elected as a "2022 Gusu Innovation and Entrepreneurship Leading Talent". In May 2022, the company has received the approval to set up a Doctors workstation in Guangdong Province by the Human Resources and Social Security Department of Guangdong Province. Financial Highlights As of 31 December 2022, the company's research and development costs increased by RMB828 million, up by 7.8%, from RMB767.9 million for the year ended 31 December 2021. The increased R&D costs were mainly attributable to the ongoing Phase III clinical trials, including those of Pruxelutamide for the indication of COVID-19 and mCRPC, and KX-826 for the indication of AGA during the reporting period. The company had cash and cash equivalents and time deposits of RMB875.3 million as at 31 December 2022, including utilised bank facilities of RMB 276.5 million. In addition, the company also had unutilised bank facilities of RMB 120.0 million as at 31 December 2022. The company has sufficient cash on hand to support the advancement of the clinical trials and R&D. *For more details, please refer to the 2022 annual results announcement. About Kintor Pharmaceutical Limited Kintor Pharmaceutical Limited is developing and commercializing a robust pipeline of innovative small molecule and biological therapeutics for androgen-receptor-related disease areas with unmet medical needs, including COVID-19, prostate, breast and liver cancers, alopecia and acne. For more information, visit . Company Codes: HongKong:9939

Phase 1Clinical ResultPhase 2Financial Statement

21 Mar 2023

·www.biospace.com

Kintor Pharma's KX-826 and GT20029 for Treatment of Androgenetic Alopecia (AGA) and Acne Presented at AAD 2023

SUZHOU, China, March 21, 2023 /PRNewswire/ -- The 2023 Annual Meeting of American Academy of Dermatology Association (AAD 2023) was held from 17 to 21 March 2023 in New Orleans, Louisiana, United States. As one of the largest, most influential and representative of all dermatologic associations, dermatologists from around the world shared the latest research advances in the field of dermatology. Kintor Pharmaceutical Limited ("Kintor Pharma", HKEX: 9939)'s self-developed and potential first-in-class topical drug candidates pyrilutamide (KX-826) and GT20029 have attracted a lot of attention at the meeting, demonstrating the company's innovative capabilities and the therapeutic potential of its androgenetic alopecia (AGA) and acne pipelines. At AAD 2023, Ken Washenik, M.D., Ph.D., FISHRS, FAAD, President and Chief Medical Officer of Bosley Medical Group and Clinical Assistant Professor of Ronald O. Perelman Department of Dermatology at New York University Grossman School of Medicine, shared the MoA and data of KX-826 and GT20029 for treatment of AGA in a presentation entitled "The Emerging Potential of Topical Androgen Modulators in Androgenetic Alopecia". Dr. Ken Washenik highlighted the emerging potential of topical androgen receptor (AR) modulators in AGA. He said that the potential of an effective topical AR blocker without systemic side-effects has long been promising. In addition, Adelaide Hebert, M.D., Director of Pediatric Dermatology at McGovern School of Medicine, University of Texas Health Science Center at Houston, shared the MoA and clinical trial design of KX-826 for treatment of acne in a presentation entitled "The Role of Topical Therapies Involving Androgen Hormones in Acne: Available and Future Therapies". Dr. Adelaide Hebert said that androgens and androgen receptors would play a key role in acne pathogenesis and represent important treatment targets. KX-826 is a topical AR antagonist under development by Kintor Pharma. The MoA of KX-826 for treatment of AGA is to locally block the androgen mediated signaling by competing with Dihydrotestosterone (DHT), limit the miniaturization of hair follicles and promote the growth of terminal hairs. KX-826 is quickly metabolized to the deactivated metabolite when arriving at the circulation system, contributing to least impact on systemic AR signaling pathway and a favorable safety profile. The Phase II clinical trial of KX-826 for male AGA adults in China showed that, after 24 weeks of treatment, the non-vellus target area hair count (TAHC) in the 5mg (0.5% concentration) twice daily (BID) KX-826 group increased by 15.34/cm2 compared with the placebo group from baseline, with a statistical difference (P=0.024). At present, Kintor Pharma is conducting the Phase III clinical trial in China and the Phase II clinical trial in the US of KX-826 for male AGA, and planning to conduct the Phase III clinical trial in China of KX-826 for female AGA and the global multi-center Phase III clinical trials of KX-826 for male and female AGA. The MoA of KX-826 for treatment of acne is to compete with DHT for binding to ARs, inhibiting gene expression that reduces sebum production and inflammation. The Phase II clinical trial of KX-826 for acne in China is ongoing, and the enrollment of all subjects has been completed in October 2022. GT20029 is a topical AR-Proteolysis Targeting Chimera (PROTAC) owned by Kintor Pharma. In preclinical studies, by degrading AR protein, GT20029 could block the shrinkage and miniaturization of hair follicles which was caused by the activation of AR signaling pathway. As the result, it prevented the hair from thinning, softening and falling out. GT20029 could also effectively inhibit sebaceous gland development and sebum secretion. GT20029 could avoid high systemic exposure and achieve a better safety profile. GT20029's Phase I clinical trials for treatment of AGA and acne in China and the US have been completed. About Kintor Pharmaceutical Limited Kintor Pharmaceutical Limited is developing and commercializing a robust pipeline of innovative small molecule and biological therapeutics for oncology and androgen-receptor-related disease areas with unmet medical needs, including COVID-19, prostate cancer, alopecia, acne, liver and breast cancers. For more information, visit . View original content to download multimedia: SOURCE Kintor Pharma Company Codes: HongKong:9939

Phase 2Clinical ResultPhase 1

100 Deals associated with GT-20029

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Indication	Highest Phase	Country/Location	Organization	Date
Acne Vulgaris	Phase 2	CN	Suzhou Kintor Pharmaceuticals, Inc.	22 Mar 2024
Androgenetic Alopecia	Phase 2	CN	Suzhou Kintor Pharmaceuticals, Inc.	13 Apr 2023

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


GT20029-CN-1001 (EADV2023)	Phase 1	-	95	GT20029 gel (1 mg)	svfxlawten(lszchvmvjc) = The most reported DRAEs (≥ 10%) were rash, skin exfoliation, and pruritus. Less DRAEs incidences were observed in Stage 2 compared to that treated with gel wruawrljcw (smgxoonoyy )	-	11 Oct 2023
				GT20029 gel (2 mg)

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