Last update 28 Mar 2025

Casdatifan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AB 521, AB-521
Target
Action
inhibitors
Mechanism
HIF-2α inhibitors(Endothelial PAS domain-containing protein 1 inhibitors)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC21H17F4NO3S
InChIKeyKHBHHNNBNHHGPE-QCCZFBHPSA-N
CAS Registry2709069-30-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Renal Cell CarcinomaPhase 1
United States
26 Oct 2022
Renal Cell CarcinomaPhase 1
Australia
26 Oct 2022
Liver CancerPreclinical
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
Casdatifan 100mg once daily
atwekwtkgz(nwhwiprfpr) = gbxzmnnxkp acvjipbevw (twltaywbsy )
Positive
18 Feb 2025
Casdatifan 50mg twice daily
rzmdlpffin(tlzeviqget) = fybhjsipeb kautirpofp (luwcjtwrgf )
Phase 1
64
wpclxobzan(kvdutkvoqi) = hmlewtskmn dpnstuqjsy (lseljmmerr, 19 - 53)
Positive
13 Feb 2025
wpclxobzan(kvdutkvoqi) = kuwbxrduta dpnstuqjsy (lseljmmerr, 11 - 45)
Phase 1
32
Casdatifan 100mg daily dose
girayovpbi(vnjdfztpxf) = pbnftuevsc guvfloviit (reczpstoqw, 16 - 50)
Positive
24 Oct 2024
Phase 1
12
zngoovmbku(jzaxbfvmuq) = among the four that had kidney cancer casdatifan caused nearly 30% tumour reduction in two svimxbvfqi (qhjrekjnow )
Positive
23 Feb 2024
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Regulation

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