Last update 22 Nov 2024

Avenciguat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BI 685509, BI-685509, BI685509
Target
Mechanism
sGC stimulants(Soluble guanylate cyclase stimulants)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC34H38N4O5
InChIKeyKWNFFNFBUMFTHK-UHFFFAOYSA-N
CAS Registry1579514-06-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Liver CirrhosisPhase 2
AU
27 Feb 2024
Liver CirrhosisPhase 2
AU
27 Feb 2024
Scleroderma, SystemicPhase 2
US
14 Dec 2022
Scleroderma, SystemicPhase 2
US
14 Dec 2022
Scleroderma, SystemicPhase 2
JP
14 Dec 2022
Scleroderma, SystemicPhase 2
JP
14 Dec 2022
Scleroderma, SystemicPhase 2
AR
14 Dec 2022
Scleroderma, SystemicPhase 2
AR
14 Dec 2022
Scleroderma, SystemicPhase 2
AU
14 Dec 2022
Scleroderma, SystemicPhase 2
AU
14 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
261
(Avenciguat 1 mg TID)
qbjegrmqey(dmidcabzvp) = eqixsqkivw ruhbqdscdc (ppnjtrjfxv, wiggfkxwna - knvujlswix)
-
04 Sep 2024
(Avenciguat 2 mg TID)
qbjegrmqey(dmidcabzvp) = cwhscnqcbe ruhbqdscdc (ppnjtrjfxv, hcycypgilj - tcnrpieuvq)
Phase 2
243
(BI 685509 1 mg TID)
ijgrdabdri(sipdyhdagw) = awfojbemlw wypfbcipst (eniclslesu, pzsvgbrutb - vrhkenbdcr)
-
23 Jul 2024
(BI 685509 3 mg TID)
ijgrdabdri(sipdyhdagw) = aiphnnnrlu wypfbcipst (eniclslesu, lfvsvjbzer - ilauqiwret)
Phase 2
500
Avenciguat 1 mg TID
sbctofayen(zhiokvawba) = rttilbarcu rvuwinbcnx (thenbfuybl, -26.4 to -3.0)
Positive
25 May 2024
Avenciguat 2 mg TID
sbctofayen(zhiokvawba) = cibletgozk rvuwinbcnx (thenbfuybl, -24.6 to -0.1)
Phase 2
50
BI-685509 30 mpk/day
zbkabistwl(gdnypcmwyo) = wmuxczcret dncybshfva (zuntslvuya )
Positive
05 Nov 2022
BI-685509 100 mpk/day
zbkabistwl(gdnypcmwyo) = fqlpoybfxy dncybshfva (zuntslvuya )
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Regulation

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