Request Demo

Last update 19 Jul 2026

Ciclesonide

Last update 19 Jul 2026

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ciclesonide (JAN/USAN/INN), B-9207-015, BTR-15

+ [15]

Target

Action

agonists

Mechanism

GR agonists(Glucocorticoid receptor agonists)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesOtorhinolaryngologic Diseases+ [1]

Active Indication

Rhinitis, Allergic, PerennialRhinitis, Allergic, SeasonalAsthma

Inactive Indication

Childhood asthmaCoughCOVID-19+ [5]

Originator Organization

Takeda Pharmaceutical Co., Ltd.

Active Organization

Azurity Pharmaceuticals, Inc.Teijin Pharma Ltd.Anhui Willman Pharmaceutical Co. Ltd.

+ [3]

Inactive Organization

AstraZeneca PLC

Sumitomo Pharma America, Inc.

Sanofi

+ [5]

License Organization

Covis Pharma Holdings BV

Sumitomo Pharma America, Inc.

Nycomed Pharma

+ [3]

Drug Highest PhaseApproved

First Approval Date

Australia (24 Feb 2004),

Asthma

Regulation-

Structure/Sequence

Molecular FormulaC32H44O7

InChIKeyLUKZNWIVRBCLON-GXOBDPJESA-N

CAS Registry126544-47-6

108

Clinical Trials associated with Ciclesonide

CTR20244577

/ CompletedNot Applicable

环索奈德吸入气雾剂在健康受试者中随机、开放、单剂量、两制剂、两序列、两周期交叉空腹状态下的生物等效性试验

[Translation] A randomized, open-label, single-dose, two-formulation, two-sequence, two-period crossover bioequivalence study of ciclesonide inhalation aerosol in healthy subjects under fasting conditions

主要目的：健康受试者空腹状态下，经口吸入给药单剂量环索奈德吸入气雾剂（受试制剂T，上海上药信谊药厂有限公司生产，规格：160μg/揿）与环索奈德吸入气雾剂（参比制剂R，Covis Pharma Gmbh生产，商品名：Alvesco®，规格：160μg/揿）后，本次试验考察空腹条件下受试制剂与参比制剂在人体内的吸收速度和吸收程度，评价受试制剂与参比制剂是否具有生物等效性。次要目的：观察受试制剂环索奈德吸入气雾剂和参比制剂环索奈德吸入气雾剂（Alvesco®）在健康受试者中的安全性。

[Translation]

Primary objective: After oral administration of a single dose of ciclesonide inhalation aerosol (test preparation T, produced by Shanghai SPH Xinyi Pharmaceutical Co., Ltd., specification: 160μg/press) and ciclesonide inhalation aerosol (reference preparation R, produced by Covis Pharma Gmbh, trade name: Alvesco®, specification: 160μg/press) to healthy subjects in the fasting state, this study investigates the absorption rate and extent of the test preparation and the reference preparation in the human body under fasting conditions, and evaluates whether the test preparation and the reference preparation are bioequivalent. Secondary objective: To observe the safety of the test preparation ciclesonide inhalation aerosol and the reference preparation ciclesonide inhalation aerosol (Alvesco®) in healthy subjects.

Start Date21 Nov 2024

Sponsor / Collaborator

Shanghai Sine Pharmaceutical Co. Ltd.

CTR20233942

/ CompletedNot Applicable

环索奈德气雾剂在健康受试者中随机、开放、单剂量、两制剂、两序列、两周期交叉空腹状态下的生物等效性试验

[Translation] A randomized, open-label, single-dose, two-formulation, two-sequence, two-period crossover bioequivalence study of ciclesonide aerosol in healthy subjects under fasting conditions

主要目的：健康受试者空腹状态下，经口吸入单次给药环索奈德气雾剂（受试制剂T，上海上药信谊药厂有限公司生产，规格：80μg/揿）与环索奈德气雾剂（参比制剂R，Covis Pharma Gmbh生产，商品名：Alvesco®，规格：80μg/揿）后，考察空腹条件下受试制剂与参比制剂在人体内的吸收速度和吸收程度，评价受试制剂与参比制剂是否具有生物等效性。次要目的：观察受试制剂环索奈德气雾剂和参比制剂环索奈德气雾剂（Alvesco®）在健康受试者中的安全性。

[Translation]

Primary objective: To investigate the absorption rate and extent of the test preparation and the reference preparation in the human body after oral inhalation of a single dose of ciclesonide aerosol (test preparation T, produced by Shanghai SPH Xinyi Pharmaceutical Co., Ltd., specification: 80μg/press) and ciclesonide aerosol (reference preparation R, produced by Covis Pharma Gmbh, trade name: Alvesco®, specification: 80μg/press) in healthy subjects under fasting conditions, and to evaluate whether the test preparation and the reference preparation are bioequivalent. Secondary objective: To observe the safety of the test preparation ciclesonide aerosol and the reference preparation ciclesonide aerosol (Alvesco®) in healthy subjects.

Start Date12 Dec 2023

Sponsor / Collaborator

Shanghai Sine Pharmaceutical Co. Ltd.

EUCTR2020-002208-37-DK

/ TerminatedPhase 2IIT

The CIMMCov-study: A Single-center, Double-blinded, Randomized, 28-days, Parallel-group, study to evaluate the effect of Ciclesonide 320 mcg inhalation twice daily versus placebo on healthcare utilization, disease progression and symptoms in the treatment of mild-to-moderate COVID-19.

Start Date29 Apr 2021

Sponsor / Collaborator-

100 Clinical Results associated with Ciclesonide

100 Translational Medicine associated with Ciclesonide

100 Patents (Medical) associated with Ciclesonide

551

Literatures (Medical) associated with Ciclesonide

01 Sep 2026·BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Bibliometric analysis of the association between asthma and cancer: Mechanistic insights and directions for clinical translation

Review

Author: Yang, Wulin ; Li, Gaopeng ; Deng, Bowen ; Guan, Rongshen

This bibliometric analysis maps the global research landscape on asthma-cancer associations (2000-2025) using 378 publications. The field is led by the United States (36%) and China (22%), with keyword co-occurrence revealing four research axes: pulmonary disease links, chronic inflammation, allergy-immunity pathways, and notably underdeveloped molecular mechanism studies. We address the central "asthma paradox"-contradictory reports of asthma as a risk, protective, or neutral factor for various cancers-by synthesizing mechanistic hypotheses. A key insight is the dynamic balance between cancer-promoting and -suppressing forces. For example, TGF-β exhibits dose-dependent duality: tumor-suppressive at low levels, but promoting immune evasion and metastasis at high concentrations characterized by severe neutrophilic asthma. Drug repurposing candidates (e.g., montelukast, ciclesonide) show anti-proliferative activity, confirming shared pathogenic pathways. We identify two primary sources of inconsistency: uncontrolled confounders (e.g., smoking) and, critically, the failure to account for asthma heterogeneity. Th2-high (allergic) and Th2-low (non-allergic/neutrophilic) endotypes likely exert divergent effects on cancer risk and progression. Current research remains predominantly epidemiological (53.5%), with mechanistic studies (16.1%) limited by these factors. To advance from associative observations to causal understanding, the study calls for future research to adopt a precision medicine framework. This includes stratifying patients by asthma endotype in large, prospective cohorts and integrating single-cell multi-omics, Mendelian randomization, and real-world data to elucidate the context-dependent molecular mechanisms, such as the dual role of TGF-β, and to validate promising drug repurposing candidates like montelukast.

01 Jun 2026·EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using experimental design

Article

Author: Sacré, Pierre-Yves ; Evrard, Brigitte ; Conrard, Louise ; Piel, Géraldine ; Hendrickx, Erika ; Bya, Laure-Anne ; Bottero, Benedetta ; Cataldo, Didier ; Dinh, Tuan Nghia ; Lechanteur, Anna ; Penoy, Noémie

Liposomes are promising carriers for pulmonary drug delivery due to their biocompatibility and controlled-release properties. However, their stability in aqueous suspension is limited, leading to aggregation and reduced therapeutic efficiency. Converting liposomal dispersions into dry powders for inhalation (DPIs) is a potential strategy to overcome these limitations. Spray-drying (SD) is particularly attractive for this purpose, offering precise control over particle properties along with speed, cost-efficiency, and scalability. Yet, the thermal and mechanical stresses involved in this process and their effects on liposomal integrity remain poorly understood, limiting its broader application. In this study, we developed a systematic framework integrating Design of Experiments (DOE) with scale-up-oriented processing, combining supercritical fluid technology (PGSS) for liposome formation with subsequent spray-drying of high solid content suspensions. Two complementary DoE approaches were applied: DOE_A optimized drying parameters and carbohydrate type, testing trehalose and hydroxypropyl-β-cyclodextrin (HPβCD), while DOE_B assessed the effects of active pharmaceutical ingredients (APIs) hydrophobicity, lipid composition (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-₂₀₀₀ (DSPE-PEG₂₀₀₀) percentage), and carbohydrate-to-liposome ratio. Optimized spray-dried powders exhibited preserved liposome structure (mean diameter < 200 nm, narrow polydispersity index (PdI), near-neutral zeta potential (ZP)), favorable aerodynamic properties (∼3 µm, extra-fine particle fraction (eFPF) > 20% and fine particle fraction (FPF) > 60%), low residual moisture (<5%), and high drying yields (>75%). Mechanistic insights revealed that HPβCD significantly protects liposomes during atomization, while drug retention was governed by PEGylated lipid content, lipid-to-carbohydrate ratio, and API hydrophobicity. Co-encapsulation of clinically relevant drug combinations (formoterol/budesonide and ciclesonide/indacaterol) produced uniform powders with efficient aerosolization, highlighting the therapeutic potential of these formulations. Collectively, these results establish a robust, scalable, and reproducible approach for designing liposomal DPIs, balancing formulation composition, excipient selection, and process parameters. This study demonstrates that strategic integration of scalable technologies can reconcile structural stability, aerodynamic performance, and manufacturability, paving the way for the industrial translation of liposomal dry powders for targeted pulmonary therapies, including asthma and chronic obstructive pulmonary disease (COPD).

01 Apr 2026·BMJ Open Respiratory Research

In vitro characterisation of fluticasone propionate and ciclesonide delivered with and without valved holding chambers using cascade impaction and an adult simulated breathing profile

Article

Author: Lehtimäki, Lauri ; Csonka, Péter ; Csonka, Leon L

Background:

Valved holding chambers (VHCs) are not interchangeable. Because VHC design and formulation type influence aerosol behaviour, each VHC–drug combination should be evaluated to inform clinical use and device selection.

Aim:

To compare the aerodynamic particle size distribution (APSD) of two inhaled corticosteroids delivered from pressurised metered dose inhalers with and without commonly used VHCs under realistic, adult-representative breathing.

Methods:

We assessed fluticasone propionate (FP, suspension) and ciclesonide (CIC, solution) using no VHC and three VHCs (AeroChamber, EasyChamber and OptiChamber Diamond). A Next Generation Impactor was connected to an anatomically representative adult throat model and a breathing simulator generating an adult-type inhalation profile.

Results:

Without a VHC, throat deposition was high. With any VHC, throat deposition fell to only a few per cent of the label claim for both FP and CIC. The 1–5 µm respirable fraction was approximately one-third of the label claim for both drugs, irrespective of VHC use, while CIC generated a larger submicron fraction than FP. Small statistically significant differences between VHCs were observed, but absolute differences in APSD and throat deposition were modest.

Conclusions:

In adult-representative conditions, VHCs substantially reduce oropharyngeal deposition but do not influence fine-particle delivery. Differences between the tested VHCs were minor and unlikely to be clinically meaningful, whereas FP and CIC showed distinct APSD profiles consistent with formulation type. These findings support performance-based, drug-specific evaluation of VHCs and underscore the value of systematic in vitro testing to guide evidence-based spacer–drug selection and to reduce throat deposition in clinical practice.

News (Medical) associated with Ciclesonide

12 May 2023

·www.drugs.com

Get Relief With the Most Common Asthma Medications

FRIDAY, May 12, 2023 -- Receiving a diagnosis of asthma may be frightening, but learning what the treatment options are can help alleviate the anxiety that comes with diagnosis. Depending on the severity, certain asthma medications may help you manage your symptoms. Here, experts break down the most common long-term and quick-acting medications for asthma, how they work and potential side effects. Long-term medications These drugs are ones the patient takes daily as a means of controlling asthma and preventing asthma attacks. These can be in pill form or used as inhalers. Bronchodilators: Long-acting beta-2 agonists (LABA) relax the muscle bands around your airway (bronchi), making it easier to get air in and mucus out. These medications for asthma are taken twice a day through an inhaler and last up to 12 hours, according to the Cleveland Clinic . LABA medications should be given with a corticosteroid. (See combination medications below.) The main side effects of LABA medications are nervous or shaky feelings, hyperactivity, overexcitement, increased heart rate, upset stomach and trouble sleeping. Salmeterol (Serevent) Formoterol (Foradil) Long-acting muscarinic antagonists (LAMA) also relax the muscle bands around your airway, the National Heart, Lung, and Blood Institute (NHLBI) says. This asthma medication is used if the steroid/LABA combination doesn’t give enough relief. Do not use this medication if you have glaucoma or are at risk of urinary retention. Tiotropium bromide (Respimat) Theophylline. While not used often, theophylline can be useful in relaxing the airways and preventing reactions to irritants. It is taken as a pill and used for mild asthma symptoms. You may need to have blood tests drawn on a regular basis to make sure the level of medication is correct, the Mayo Clinic says. Side effects are the same as the other bronchodilators, but may also include chest pain or discomfort, dizziness, fainting, increase in urine volume or seizures. Theophylline (Theo-24, Theo-Dur, Slo-Bid, and others) Corticosteroids: Corticosteroids are steroids that reduce inflammation in the airways, according to the NHLBI. They may be taken as a pill, although very few patients are on the pill for long term. It is frequently used in an inhaler, often combined with a LABA. Side effects from the inhaled form are thrush (a mouth infection) and a hoarse voice. Inhaled corticosteroids include: Fluticasone (Flovent HFA, Arnuity Ellipta, others) Budesonide (Pulmicort Flexhaler) Mometasone (Asmanex Twisthaler) Beclomethasone (Qvar RediHaler) Ciclesonide (Alvesco) Combination asthma medications (Corticosteroid and LABA): Fluticasone and salmeterol (Advair) Budesonide and formoterol (Symbicort) Fluticasone and Vilanterol (Breo) Leukotriene modifiers reduce swelling and help keep your airways open for up to 24 hours. According to Mayo Clinic, these medications block the effects of leukotrienes, immune system chemicals that cause asthma symptoms. Side effects are uncommon, but may include nausea, headache, tiredness or diarrhea. Montelukast (Singulair) Zafirlukast (Accolate) Zileuton (Zyflo) Quick-acting asthma medications These are a group of medications that are used when a patient has a flare-up or an asthma attack. Inhaled short-acting beta2-agonists (SABAs) open the airways so air can flow through them during an asthma attack. They start working within 15 to 20 minutes and continue to work for 4 to 6 hours, according to the Cleveland Clinic. Side effects can include tremors, rapid heartbeat, allergic reactions, muscle pain, worsening breathing, dry mouth, headache, sore throat or trouble sleeping. Inhaled forms of SABA medications include: Albuterol (Ventolin) Levalbuterol (Xopenex) Albuterol and ipratropium bromide combination (DuoNeb) Corticosteroids. Oral corticosteroids are usually prescribed for short-term use to help a patient overcome a flare-up. This type of medication quickly reduces swelling and inflammation in the airways. Side effects include: Cataracts, osteoporosis, weight gain, high blood sugar, increased risk of infections, thinning bones and fractures, thin skin, bruising and slower wound healing, mood swings, depression and aggressive behavior. Prednisone (Deltasone, Prednicot, and others ) Methylprednisolone (Medrol, Solu-Medrol, Depo-Medrol) Short-acting anticholinergic bronchodilators help open the airways quickly. This medicine may be less effective than SABAs, but it is an option for people who experience side effects with other medications, the Cleveland Clinic says. Side effects you may experience with these inhalers are dry throat, eyes and nose; unusual taste; nausea and vomiting; or temporary blurred vision if the medicine gets in your eyes. Ipratropium bromide (Atrovent) Tiotropium bromide (Spiriva Respimat) Corticosteroid reliever. In January 2023, the FDA approved Airsupra, which can be used as needed to prevent bronchoconstriction and asthma attacks. In a study conducted before the approval, the risk of severe asthma exacerbation was significantly lower with a fixed-dose combination of albuterol and budesonide than with as-needed use of albuterol alone. Most common side effects are headache, oral yeast infection, cough, and difficulty speaking. Airsupra (albuterol-budesonide) Posted May 2023

Drug Approval

01 Nov 2021

·www.biospace.com

AstraZeneca Purges Two Respiratory Medicines in Big Day for Covis

Bodo Marks/picture alliance via Getty AstraZeneca’s respiratory portfolio is a little lighter as the British-Swiss pharmaceutical behemoth announced the offloading of two chronic obstructive pulmonary disease (COPD drugs) to fellow Swiss player Covis Pharma Group for $270 million. The agreement, announced November 1, involves Eklira (marketed as Tudorza in the U.S.) and Duaklir (marketed as Brimica® in some countries). The acquisition of the medicines – which netted AstraZeneca $143 million in the geographies covered under the agreement – provides a significant boost to Covis’s respiratory portfolio. COPD was the third leading cause of death worldwide in 2019, so the need and market are certainly there. “This acquisition represents a highly strategic and synergistic transaction with AstraZeneca, enabling Covis to offer a full continuum of best-in-class therapies for allergic rhinitis, asthma and COPD,” said Covis Chief Executive Officer Michael Porter in a statement. “As a result of the acquisition, Covis is firmly placed as one of the top 10 respiratory companies in the world.” Under the terms of the agreement, Covis will pay AstraZeneca $270 million upon completion of the deal, which is expected to close in quick order prior to the end of Q4 2021. In addition, Covis will be responsible for ongoing development costs related to the medicines. Eklira is a long-acting muscarinic antagonist (LAMA), while Duaklir is a combination therapy that contains both a LAMA and a long-acting beta2-agonist. Both are presented as a dry powder for inhalation and delivered through a breath-actuated multi-dose dry powder inhaler called Genuair (Pressair in the US). AstraZeneca CEO Pascal Soriot has made no secret of his intention to steer the company's R&D pipeline to a predominantly oncology focus, and Covis is a repeat partner. In 2018, AstraZeneca divested three Asthma and Rhinitis Drugs to Covis for $350 Million. In this instance, the large multinational sold rights to Alvesco (ciclesonide), which is intended to treat persistent asthma, and Omnaris and Zetonna (ciclesonide), which are aimed at treating nasal symptoms associated with rhinitis. In April, Covis announced disappointing results from a Phase III trial evaluating Alvesco in COVID-19. The results were deemed not statistically significant, though Dr. Michael Blaiss, MD, clinical professor at the Medical College of Georgia at Augusta University in Augusta, Georgia and a member of the steering committee for the trial said that “further studies may want to look at whether this treatment may prevent or lessen post-acute COVID-19 syndrome.” AstraZeneca also said the deal will enable a sharpening of its focus on priority medicines in the respiratory and immunology space. The company went on to state in its official press release that the agreement “will ensure continued patient access to these established medicines.” With European headquarters in Zug as well as Amsterdam, Covis is a global specialty pharma company that markets therapeutics for patients with life-threatening conditions and chronic illnesses including asthma, COPD and anemia. Featured Jobs on BioSpace

Acquisition

18 Apr 2021

·www.globenewswire.com

COVIS PHARMA GROUP Announces Top-line Safety and Efficacy

ZUG, Switzerland, April 15, 2021 (GLOBE NEWSWIRE) -- Covis Pharma Group (the “Company”), a global specialty pharmaceutical company that markets therapeutic solutions for patients with life-threatening conditions and chronic illnesses, announced today top-line results from a 400 patient phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the safety and efficacy of ciclesonide metered-dose inhaler in non-hospitalized patients 12 years of age and older with symptomatic COVID-19 infection. The primary endpoint of the study was time to alleviation of COVID-19-related symptoms of cough, dyspnea, chills, feeling feverish, repeated shaking with chills, muscle pain, headache, sore throat, and new loss of taste or smell, defined as symptom-free for a continuous period of ≥ 24 hours by Day 30. A sub-group analysis showed that time to alleviation of cough was the most improved symptom in the ciclesonide arm compared to the placebo arm by 6 days in 75% of the population. A relevant secondary efficacy endpoint reaching statistical significance (p=0.0301) was the 70% reduction observed in the ciclesonide arm versus 30% in the placebo arm of patients with subsequent emergency department visits or hospital admissions for reasons attributable to COVID-19 by Day 30. There were only a small number (n=10) of total events observed in this study. No new safety signals were identified with ciclesonide 320mcg twice daily for 30 days in the active comparator arm versus placebo. In addition, no new adverse events were reported after 60 days post treatment with ciclesonide. The study randomized 400 patients in a 1:1 ratio to ciclesonide versus placebo. The study demonstrated a treatment difference between ciclesonide (70.6%) and placebo (63.5%) in the percentage of patients with an improved time to alleviation of COVID-19 related symptoms, which was not statistically significant, with a p-value of 0.5502. “We are disappointed the results were not more positive, although there was a trend toward earlier cough cessation in the ciclesonide group. Further studies may want to look at whether this treatment may prevent or lessen post-acute COVID-19 syndrome,” said Michael Blaiss, MD, clinical professor at the Medical College of Georgia at Augusta University in Augusta, Georgia, a member of the steering committee for the trial. About AlvescoAlvesco (ciclesonide) Inhalation Aerosol is a glucocorticoid indicated for the long-term treatment of asthma as maintenance therapy in adults and adolescents 12 years of age and older in the U.S. and over 6 years of age in Canada. Alvesco Inhalation Aerosol is an inhaled glucocorticoid with a small particle size (1-2 μm) enabling it to reach areas of chronic inflammation in both the large and small airways. Alvesco is not indicated for the relief of acute bronchospasm. Alvesco is not indicated for children under 12 years of age in the U.S. or under the age of 6 in Canada. Canada Indication: ALVESCO is indicated for the prophylactic management of steroid-responsive bronchial asthma in adults, adolescents and children 6 years of age and older.Contraindications: United States of America Indication: ALVESCO is indicated for the maintenance treatment of asthma as prophylactic therapy in adults and adolescents 12 years of age and older.Important Limitations of USE: Important Safety Information for Alvesco (ciclesonide) Inhalation Aerosol Contraindications Warnings & Precautions Please read Important Safety Information and Full Prescribing Information for the US and Canada PM. About Covis Covis, with global operations in Zug, Switzerland, is a global specialty pharmaceutical company that markets therapeutic solutions for patients with life-threatening conditions and chronic illnesses. Additional information is available at . Trademarks are the property of their respective owners. Media Contactinfo@covispharma.com

100 Deals associated with Ciclesonide

External Link

KEGG	Wiki	ATC	Drug Bank
D01703	Ciclesonide	R01AD13 R03BA08	DB01410

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Rhinitis, Allergic, Perennial	United States	Azurity Pharmaceuticals, Inc.	20 Oct 2006
Rhinitis, Allergic, Seasonal	United States	Azurity Pharmaceuticals, Inc.	20 Oct 2006
Asthma	Australia	CHIESI Farmaceutici SpA	24 Feb 2004

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Phase 3	United States	Covis Pharma Holdings BV	08 Jun 2020
Cough	Phase 3	Estonia	Sanofi-Aventis, Inc.	16 Jun 2006
Dyspnea	Phase 3	Estonia	Sanofi-Aventis, Inc.	16 Jun 2006
Pulmonary Disease, Chronic Obstructive	Phase 3	Estonia	Sanofi-Aventis, Inc.	16 Jun 2006
Seasonal rhinitis	Phase 3	United States	AstraZeneca PLC	01 Mar 2006
Childhood asthma	Phase 3	Brazil	AstraZeneca PLC	01 Oct 2004
Childhood asthma	Phase 3	Germany	AstraZeneca PLC	01 Oct 2004
Childhood asthma	Phase 3	Hungary	AstraZeneca PLC	01 Oct 2004
Childhood asthma	Phase 3	Poland	AstraZeneca PLC	01 Oct 2004
Childhood asthma	Phase 3	Portugal	AstraZeneca PLC	01 Oct 2004

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04356495 (COVERAGE, ERS2023)	Phase 2/3	COVID-19	225	Placebo	wvguovspxk(ylroltcvrg) = inhaled IFN-β-1b, but not inhaled ciclesonide nor placebo, was linked to a decrease in plasma H3Cit levels (p: 0.02). cjcwjeltfb (epejppwqsg ) View more	Positive	09 Sep 2023
				Inhaled IFN-β-1b
NCT04381364 (HALT COVID-19, Pubmed \| BMJ Open)	Phase 2	COVID-19	98	Inhaled ciclesonide 320 µg	slgtltakbi(nedtlhjqtv) = nusovoojlg xzqpsbnbdm (tklvnafuae )	-	22 Feb 2023
				ciclesonide (Standard care)	slgtltakbi(nedtlhjqtv) = byqbqsjaan xzqpsbnbdm (tklvnafuae )
NCT04435795 (CONTAIN, CTgov)	Phase 2/3	COVID-19	215	Ciclesonide (Ciclesonide Inhaled and Nasal)	exmjyfdiqq = nubjmnusvb viibajydzf (tagxpyapga, mbcqirorcz - pkkfmkxxnq) View more	-	29 Apr 2022
				Normal Saline intranasal and placebo inhaler (Placebo)	exmjyfdiqq = ezivwimgnd viibajydzf (tagxpyapga, jvnnxonjag - gbrhpuxlne) View more
NCT00458835 (BY9010/M1-422, CTgov)	Phase 4	Rhinitis, Allergic	30	Ciclesonide (Ciclesonide Nasal Spray)	lbegevfqeb(pdespnezur) = bldcsjzwwa qtduofvijg (iykqzwbfnn, hkesoatdmt - dehqvkvche) View more	-	02 Mar 2022
				Ciclesonide (Ciclesonide Nasal Aerosol)	lbegevfqeb(pdespnezur) = xfzneucban qtduofvijg (iykqzwbfnn, qygnmfilts - fpmjroenix) View more
NCT04377711 (CTgov)	Phase 3	COVID-19	400	Ciclesonide (Group 1)	rptcbprboq(admalphgid) = vahiuspaih hwvpwegxtr (plfcffppae, zezunhztvo - qrbpyddtit) View more	-	06 Jan 2022
				Placebo (Group 2)	rptcbprboq(admalphgid) = kddsffhdkq hwvpwegxtr (plfcffppae, cwrfeehxaa - gdtrjhvsem) View more
NCT04377711 (Pubmed \| JAMA Intern Med) Manual	Phase 3	COVID-19	400	Ciclesonide	xcmwnucusm(yvgqomnhoz) = jfhpqpwlmt dpeoisjtzo (oqjjtzrhwp, 14.0 - 21.0)	Negative	22 Nov 2021
				Placebo	xcmwnucusm(yvgqomnhoz) = miibofvzwg dpeoisjtzo (oqjjtzrhwp, 16.0 - 23.0)
NCT04435795 (CONTAIN, Pubmed \| BMJ)	Phase 2	COVID-19	203	Inhaled ciclesonide (600 μg twice daily) and intranasal ciclesonide (200 μg daily)	lejpetslcc(mtufnojrhc) = mdemlsvliy lpblcwoprj (wtcrzyetwx )	Negative	02 Nov 2021
				Metered dose inhaler and nasal saline placebos	lejpetslcc(mtufnojrhc) = hmncdbpvml lpblcwoprj (wtcrzyetwx )
NCT04330586 (Pubmed \| J Clin Med) Manual	Phase 2	COVID-19	61	ciclesonide	ugbhdfznxi(vfcvpnvvoo) = The SARS-CoV-2 eradication rate at day 14 was significantly higher in the ciclesonide group. lohvtrbcet (mkerzfyubp ) View more	Positive	12 Aug 2021
				standard care
NCT01455194 (CONTRAST, CTgov)	Phase 3	Asthma \| Persistent asthma	520	Ciclesonide (Treatment Period: Ciclesonide 160 mcg)	rbpqxztczl(wxwfgflefa) = unaayspbjy toqvmnyhol (vzolotldcf, 0.031) View more	-	25 Oct 2016
				Ciclesonide (Treatment Period: Ciclesonide 320 mcg)	rbpqxztczl(wxwfgflefa) = imhnkxsfgy toqvmnyhol (vzolotldcf, 0.035) View more
NCT02155881 (CTgov)	Phase 3	Rhinitis, Allergic, Seasonal	80	Ciclesonide (Ciclesonide 200 mcg)	jmawrizfam(ppheeivgum) = nxzyehuput bvuprwvhvc (ajabjpxwvb, 1.83) View more	-	06 Oct 2016
				Ciclesonide Placebo (Placebo)	jmawrizfam(ppheeivgum) = ierngaiamo bvuprwvhvc (ajabjpxwvb, 1.63) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Ciclesonide

Overview

Basic Info

Structure/Sequence

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation