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Last update 27 Mar 2025
RC-148
Last update 27 Mar 2025
Overview
Basic Info
Drug Type Bispecific antibody |
Synonyms RC 148, RC148 |
Target |
Action modulators |
Mechanism PD-1 modulators(Programmed cell death protein 1 modulators), VEGF modulators(Vascular endothelial growth factor modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Sequence Code 160581189
Related
8
Clinical Trials associated with RC-148NCT06883630
A Phase Ib, Multi-Cohort, Open-Label, Multi-Center Clinical Trial to Evaluate the Efficacy and Safety of RC148 Injection as Monotherapy or Combination Therapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer.
NCT06642545
A Randomized, Open-label, Controlled, Multicenter Phase II Study to Evaluate the Efficacy and Safety of Disitamab Vedotin Combined With RC148 Versus Albumin-bound Paclitaxone Alone or in Combination With Toripalimab in Subjects With HR-negative, HER2-low Expressing Unresectable Locally Advanced or Metastatic Breast Cancer
CTR20243539
评价维迪西妥单抗联合RC148对照白蛋白结合型紫杉醇单药或联合特瑞普利单抗治疗HR阴性HER2低表达的不可切除的局部晚期或转移性乳腺癌受试者有效性和安全性的随机、开放、对照、多中心II期临床研究
[Translation] A randomized, open-label, controlled, multicenter phase II clinical study to evaluate the efficacy and safety of vedicizumab combined with RC148 or nab-paclitaxel alone or combined with toripalimab in the treatment of patients with HR-negative, HER2-low-expressing, unresectable locally advanced or metastatic breast cancer
100 Clinical Results associated with RC-148
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100 Translational Medicine associated with RC-148
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100 Patents (Medical) associated with RC-148
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100 Deals associated with RC-148
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| HR-negative/HER2-low Breast Carcinoma | Phase 2 | China | 10 Feb 2025 | |
| Adenocarcinoma of Lung | Phase 2 | China | 14 Sep 2023 | |
| Advanced Lung Adenocarcinoma | Phase 2 | China | 14 Sep 2023 | |
| Advanced Lung Non-Small Cell Carcinoma | Phase 2 | China | 14 Sep 2023 | |
| HER2-expressing Gastric Adenocarcinoma | Phase 2 | China | 14 Sep 2023 | |
| Metastatic Carcinoma to the Uterine Cervix | Phase 2 | China | 14 Sep 2023 | |
| Ovarian Serous Tumor | Phase 2 | China | 14 Sep 2023 | |
| Platinum-Resistant Primary Peritoneal Carcinoma | Phase 2 | China | 14 Sep 2023 | |
| Platinum-Sensitive Primary Peritoneal Carcinoma | Phase 2 | China | 14 Sep 2023 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 07 Sep 2023 |
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