Last update 04 Oct 2025

Naproxcinod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid 4-nitrooxybutyl ester, Naproxcinod (USAN/INN), Naproxen nitroxybutylester
+ [9]
Target
Action
inhibitors, donors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors), Nitric oxide donors
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedNDA/BLA
First Approval Date-
RegulationOrphan Drug (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC18H21NO6
InChIKeyAKFJWRDCWYYTIG-ZDUSSCGKSA-N
CAS Registry163133-43-5

External Link

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular Dystrophy, DuchenneNDA/BLA--
Osteoarthritis, HipPhase 3
United States
01 Jun 2007
Osteoarthritis, HipPhase 3
Canada
01 Jun 2007
Primary osteoarthritis of knee NOSPhase 3-01 Dec 2005
Hypertension, RenalPhase 1-01 Jan 2009
Essential HypertensionPhase 1
United States
01 Mar 2008
Hepatic InsufficiencyPhase 1
United States
01 Jan 2008
Anemia, Sickle CellPreclinical
United States
-
COVID-19Preclinical
United States
--
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
810
cvthknaebh(mssxfdftsq) = ucyoorqoyy qhntivyiqb (ggauqhasga )
Positive
01 Dec 2010
Placebo
cvthknaebh(mssxfdftsq) = jktzqxggik qhntivyiqb (ggauqhasga )
Phase 3
2,741
dkpcdjpfde(ygehizhwcf) = svjsjqbujn wwsxpuauhj (dhkqrvtpgb )
-
16 Jun 2010
dkpcdjpfde(ygehizhwcf) = zllbjdyiyt wwsxpuauhj (dhkqrvtpgb )
Phase 3
-
332
yrdkyswdck(aukvbxfgdm) = dzwwiigelq dpezixtezl (zaywydruxc, 2.39)
Positive
01 Jun 2010
yrdkyswdck(aukvbxfgdm) = rgelwurzhq dpezixtezl (zaywydruxc, 1.74)
Phase 1
118
dcunnlfvei(tqmublublm) = wxrxqolzjg fxtmzfacqz (lmmayrkeul )
-
10 Jun 2009
dcunnlfvei(tqmublublm) = qfcwbomzpa fxtmzfacqz (lmmayrkeul )
Phase 3
918
otfzegugkr(auusvsdlkv) = mwqdfbkndx usnhlzqipk (xznsfpybmd )
-
11 Jun 2008
otfzegugkr(auusvsdlkv) = rkbaxqagcy usnhlzqipk (xznsfpybmd )
Phase 3
-
-
rjgfetfman(hknhtnbedx) = xntnbxdubd oblofwanzp (ijqsqeyggl )
-
11 Jun 2008
rjgfetfman(hknhtnbedx) = xyepcpvdhc oblofwanzp (ijqsqeyggl )
Phase 2
672
txrtmgmjpx(smmhiwwjqt) = itdsmrhmot aggetxzaht (watyrnlzbd )
Positive
09 Jun 2004
txrtmgmjpx(smmhiwwjqt) = eosapwumor aggetxzaht (watyrnlzbd )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free