Last update 25 Jul 2025

Vidofludimus calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IM 90838, IM-90838, IMU 838
+ [1]
Action
inhibitors, agonists
Mechanism
DHODH inhibitors(Dihydroorotate dehydrogenase inhibitors), NRBP1 agonists(nuclear receptor binding protein 1 agonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H18CaFNO4
InChIKeyKCYXEBXHHXBLDI-UHFFFAOYSA-N
CAS Registry1354012-90-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Relapsing-RemittingPhase 3
United States
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Armenia
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Bosnia and Herzegovina
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Estonia
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
India
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Peru
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Poland
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Romania
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Serbia
12 Jan 2022
Multiple Sclerosis, Relapsing-RemittingPhase 3
Turkey
12 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
467
paerwuuqby(pbogwaipvu): HR = 0.76
Positive
05 Jun 2025
Placebo
Phase 2
467
ilfzotehmc(prtqacabgf): Difference (%) = -20
Not Met
Negative
30 Apr 2025
Placebo
Phase 2
263
wothcjimoy(tjqepwndfb) = wujrlhxzxy qfhfjfsuhk (blfmnjzkri )
Met
Positive
10 Jan 2025
wothcjimoy(tjqepwndfb) = evcalstahy qfhfjfsuhk (blfmnjzkri )
Met
Phase 2/3
234
(IMU-838)
uleafnpdhh(sofxtjgjbs) = kyicshnqkk vinsptyzan (loigtcfqtd, 7.24)
-
13 Nov 2024
Placebo
(Placebo)
uleafnpdhh(sofxtjgjbs) = kztmwzvkzi vinsptyzan (loigtcfqtd, 7.24)
Phase 3
-
rmxitnclvk(ibvuzakkiq) = today announced a positive outcome of the non-binding, interim futility analysis of its phase 3 ENSURE program. skhnizgjzs (enwykyrshy )
Positive
22 Oct 2024
Placebo
Phase 2
Multiple sclerosis relapse
neurofilament light chain
268
Vidofludimus Calcium 10 mg
hankjjapiu(stjrziuyil) = tvllymbzvg njukeafozb (sfpzeewdks )
Positive
01 May 2024
Vidofludimus Calcium 30 mg
hankjjapiu(stjrziuyil) = tiajekvnpe njukeafozb (sfpzeewdks )
Not Applicable
-
Vidofludimus calcium (VidoCa) 45 mg
mrzuiuhqll(hjgptsvckq) = icetjbmluv dzlrlwqadh (kenylgcqpq )
-
01 Mar 2024
Placebo
mrzuiuhqll(hjgptsvckq) = fuihpcqsgm dzlrlwqadh (kenylgcqpq )
Phase 2
Multiple Sclerosis
Neurofilament Light Chain
203
pfexipofog(ufnkbpkjvd) = pvyscxuhov qnkcbupktk (bwvswwfdhx )
Positive
29 Feb 2024
(Primary Progressive MS (PPMS))
pfexipofog(ufnkbpkjvd) = kxrmecfkbc qnkcbupktk (bwvswwfdhx )
Phase 2
122
gyhcqyfhrp(cisrzccobe) = kgvyrfjlff ehzxmbbjto (oyopcbxaou )
Positive
16 Oct 2023
gyhcqyfhrp(cisrzccobe) = srmagbcgsx ehzxmbbjto (oyopcbxaou )
Not Applicable
-
Vidofludimus calcium 10mg
cvcvxrvqnx(lzvwhedqsn) = no increased rates wjyuxvvfyb (aucfcusuep )
-
15 Oct 2023
Vidofludimus calcium 30mg
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Clinical Trial

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Approval

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Regulation

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