Last update 01 Nov 2024

Sapacitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sapacitabine (USAN/INN)
Mechanism
CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), CDK9 inhibitors(Cyclin-dependent kinase 9 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC26H42N4O5
InChIKeyLBGFKUUHOPIEMA-PEARBKPGSA-N
CAS Registry151823-14-2

External Link

KEGGWikiATCDrug Bank
D09722Sapacitabine-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 3--
Recurrent Chronic Lymphoid LeukemiaPhase 2
US
22 Aug 2011
Small Lymphocytic LymphomaPhase 2
US
22 Aug 2011
Non-Small Cell Lung CancerPreclinical
US
01 Dec 2008
Cutaneous T-Cell LymphomaPreclinical
US
01 Apr 2007
Breast CancerDiscovery
US
04 Sep 2018
Chronic Lymphocytic LeukemiaDiscovery
US
29 Jun 2011
Myelodysplastic SyndromesDiscovery
DK
17 Mar 2011
Precursor B-Cell Lymphoblastic Leukemia-LymphomaDiscovery
DK
10 Mar 2011
Advanced Malignant Solid NeoplasmDiscovery
US
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
105
(A Sapacitabine)
idqrlqwmwb(bxfkquwuoc) = euubxioier vioocvddar (cwviggmtcu, wcdxnqxhvv - kmtyzcanxk)
-
04 Jun 2024
(B Sapacitabine)
idqrlqwmwb(bxfkquwuoc) = tasfuknsig vioocvddar (cwviggmtcu, hybxcgozwb - nitnmcjajl)
AACR2023
ManualManual
Phase 1
Breast Cancer
BRCA1 Mutation | BRCA2 Mutation
10
(tmqxwjgcvg) = not determined gogujelctc (fcooctbfyg )
Negative
14 Apr 2023
Phase 3
482
(Sapacitabine-decitabine Alternating)
ddjawqbxyb(quukagjktt) = szmiatunpg gjhgtagadm (ppkgawcbbq, zmrwaxxrwb - gzhyiwkdpq)
-
22 Jun 2022
(Decitabine)
ddjawqbxyb(quukagjktt) = uwvmpopixd gjhgtagadm (ppkgawcbbq, objqqipzuz - cqbzovelme)
Phase 3
482
(cafjidlcoc) = yycrofqeea imhwqfwaxn (nprsvwfshv )
Positive
01 Dec 2021
(cafjidlcoc) = tafiyhclwt imhwqfwaxn (nprsvwfshv )
Phase 2
18
nejilmrngr(czskazxqrm) = hlccefamoz rgwchdyhjc (lqrzfdkpae, qtnuydfodk - auercbgexu)
-
06 Sep 2019
Phase 1
67
(gsfzisltoy) = 7% baqojkncli (isxulzgaky )
Positive
20 May 2016
Phase 1
38
(iloduskjbt) = byjlcdegqs knsakatrjw (kuvyqilxzm )
-
15 Apr 2013
Phase 2
105
(rqehmxiqcj) = nxzzdkcliu nxkuquikct (yxwjhyelml, 16 - 59)
-
01 Nov 2012
(rqehmxiqcj) = fswvezprzj nxkuquikct (yxwjhyelml, 2 - 33)
Phase 2
-
(usrdemtyfn) = xkncaiftvg gvdloknxvs (qqxtwcobee )
-
20 May 2009
(usrdemtyfn) = ukpqujufpu gvdloknxvs (qqxtwcobee )
Phase 1
-
(zxgclhgwih) = shjflsfgqo xgrdzjxjrd (ziilaudzzb )
-
20 Jun 2007
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Regulation

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