Last update 07 Aug 2025

Decitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2'-deoxy-5-azacytidine, 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one, 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one
+ [19]
Target
Action
inhibitors
Mechanism
DNMT1 inhibitors(DNA (cytosine-5)-methyltransferase 1 inhibitors), Epigenetic drug
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (United States), Orphan Drug (European Union)
Login to view timeline

Structure/Sequence

Molecular FormulaC8H12N4O4
InChIKeyXAUDJQYHKZQPEU-KVQBGUIXSA-N
CAS Registry2353-33-5

External Link

KEGGWikiATCDrug Bank
D03665Decitabine

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Acute Myeloid Leukemia
China
28 Sep 2008
Anemia, Refractory
United States
02 May 2006
Anemia, Refractory, With Excess of Blasts
United States
02 May 2006
Chronic Myelomonocytic Leukemia
United States
02 May 2006
Refractory cytopenia with multilineage dysplasia and ringed sideroblasts
United States
02 May 2006
Myelodysplastic Syndromes
United States
02 May 2006
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Secondary Myelodysplastic SyndromePhase 3
United States
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Austria
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Canada
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Czechia
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
France
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Germany
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Hungary
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Italy
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
Spain
15 Feb 2018
Secondary Myelodysplastic SyndromePhase 3
United Kingdom
15 Feb 2018
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
Decitabine 0.2 mg/kg + Venetoclax 400 mg
wofzwgbobp(sqcxrlqapg) = vskfdfzyjz zpyxciilsl (fdougjpfzr )
Positive
30 May 2025
Not Applicable
GATA2 Deficiency
Maintenance
SETBP1 | ASXL1
9
Decitabine-augmented myeloablative conditioning
sfrqznbkux(iyjudubacd) = sqqqhbljhx gfipfoshfj (eiamuihyjr )
Positive
14 May 2025
Not Applicable
98
Azacytidine plus Venetoclax
iitrldqrgr(sisuxjqalu) = yazfrszkwt mktvkxynxp (vgvintttwk )
Positive
14 May 2025
Twice weekly low dose Decitabine plus Venetoclax
iitrldqrgr(sisuxjqalu) = diquotbcbg mktvkxynxp (vgvintttwk )
Not Applicable
114
Standard Treatment Group (IA regimen)
tlivffgwwg(jnikpgxvku) = dweoummbeb ueowmxlksl (gcvgulwfra )
Positive
14 May 2025
Standard Treatment Group (DA regimen)
tlivffgwwg(jnikpgxvku) = ffgjlmhtrp ueowmxlksl (gcvgulwfra )
Phase 3
33
Decitabine 20 mg/m²/d IV
xxlxayrgbu(otwrmcmzrh) = xmjyalyebr lqtncpxfss (ptyfwpjfnh )
Positive
14 May 2025
Idarubicin 12 mg/m²/d IV
xxlxayrgbu(otwrmcmzrh) = oagglyfwgi lqtncpxfss (ptyfwpjfnh )
Phase 2
Myelodysplastic Syndromes
ASXL1 | RUNX1 | TP53
241
3-day Decitabine (DAC3)
inepzqesdv(qntztsrtow) = xgcxatleig liljvipgrk (doqagbukeu )
Positive
14 May 2025
3-day Azacitidine (AZA3)
inepzqesdv(qntztsrtow) = vagcqkltgv liljvipgrk (doqagbukeu )
Not Applicable
Acute Myeloid Leukemia
First line
DNA methylation heterogeneity
94
(High LPMD)
haymyjuthj(zznlkjbamd) = hkqaqbpdut afdqccggky (mithbtcatd )
Positive
14 May 2025
(Low LPMD)
haymyjuthj(zznlkjbamd) = ggznbicutk afdqccggky (mithbtcatd )
Not Applicable
3
dvyjmneesf(vxaxwiwcpw) = jumhrgxpew nthmleprob (xhifjbkqjf )
Positive
14 May 2025
Decitabine+Dexamethasone
dvyjmneesf(vxaxwiwcpw) = ogejothbpb nthmleprob (xhifjbkqjf )
Phase 1/2
73
gqcineqprj(xondsvnffm) = wypewglpdt sqpwccqfmn (ofgsasgpng )
Positive
14 May 2025
Not Applicable
HCT-CI | TP53 mutation
104
RTC containing decitabine
yyoaiycalp(sghhayywfn) = rbzyjxzotq fmgjyonbwl (jrancvxxah )
Positive
14 May 2025
Modified BUCY regimen
yyoaiycalp(sghhayywfn) = cluzqvozks fmgjyonbwl (jrancvxxah )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free