Drug Type Small molecule drug |
Synonyms THU, NSC-112907 |
Target |
Mechanism CDA inhibitors(Cytidine deaminase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC9H16N2O6 |
InChIKeyUCKYOOZPSJFJIZ-XVKVHKPRSA-N |
CAS Registry18771-50-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Carcinoma | Phase 2 | US | 11 Apr 2018 | |
Esophageal Carcinoma | Phase 2 | US | 11 Apr 2018 | |
Malignant Pleural Mesothelioma | Phase 2 | US | 11 Apr 2018 | |
Advanced Lung Non-Small Cell Carcinoma | Phase 2 | US | 20 Aug 2009 | |
Bladder Cancer | Phase 2 | US | 20 Aug 2009 | |
Breast Cancer | Phase 2 | US | 20 Aug 2009 | |
Head and Neck Neoplasms | Phase 2 | US | 20 Aug 2009 | |
Lung Cancer | Phase 2 | US | 20 Aug 2009 | |
Acute Myeloid Leukemia | Phase 2 | - | - | |
Acute Myeloid Leukemia | Phase 2 | - | - |
Phase 2 | 13 | (Nivolumab) | xdldrdizoz(vdfngemddf): P-Value = 0.05 View more | - | 10 Dec 2020 | ||
(Oral THU/Decitabine + Nivolumab) | |||||||
Early Phase 1 | 5 | Positron emission tomography (PET)/Computed tomography (CT)+Tetrahydrouridine intravenous (IV)+[F-18]-5-FLUORO-2'-DEOXYCYTIDINE | efgcjzvdhp(jhiteemxcb) = iknutmndjv xuzmkzakkm (qopvwbicrb, wiqyaxemje - haszyyxegg) View more | - | 22 May 2020 | ||
Phase 2 | 95 | tczkcfcumo(vaziawdzqd) = rxjrbkpjgm obyzjjzxdm (oojwyshlfe, garfjmwlai - fkompxnxyr) View more | - | 27 Dec 2019 | |||
Phase 2 | 13 | ayubydpbza(pbnpcxosmo) = erajecvdef ltwkiesngr (gpcksfhpvl ) | Positive | 01 Jun 2018 | |||
PBS | ayubydpbza(pbnpcxosmo) = czbelvncnt ltwkiesngr (gpcksfhpvl ) | ||||||
Phase 1 | 25 | THU-decitabine | gbtllavhmf(towbfdjkpz) = uatmvcdszh uxqqlvbghh (adosqszqsn ) View more | - | 01 Sep 2017 | ||
Phase 1 | - | tetrahydrouridine+FdCyd | qyvytnguth(dwmyidmnxl) = 100 mg/m2/day FdCyd with 350 mg/m2/day THU rervmzdshr (jyqslpztpa ) View more | Positive | 01 Mar 2015 |