Last update 07 Dec 2024

Tetrahydrouridine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
THU, NSC-112907
Target
Mechanism
CDA inhibitors(Cytidine deaminase inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC9H16N2O6
InChIKeyUCKYOOZPSJFJIZ-XVKVHKPRSA-N
CAS Registry18771-50-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CarcinomaPhase 2
US
11 Apr 2018
Esophageal CarcinomaPhase 2
US
11 Apr 2018
Malignant Pleural MesotheliomaPhase 2
US
11 Apr 2018
Advanced Lung Non-Small Cell CarcinomaPhase 2
US
20 Aug 2009
Bladder CancerPhase 2
US
20 Aug 2009
Breast CancerPhase 2
US
20 Aug 2009
Head and Neck NeoplasmsPhase 2
US
20 Aug 2009
Lung CancerPhase 2
US
20 Aug 2009
Acute Myeloid LeukemiaPhase 2--
Acute Myeloid LeukemiaPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
(Nivolumab)
xdldrdizoz(vdfngemddf): P-Value = 0.05
-
10 Dec 2020
(Oral THU/Decitabine + Nivolumab)
Early Phase 1
5
Positron emission tomography (PET)/Computed tomography (CT)+Tetrahydrouridine intravenous (IV)+[F-18]-5-FLUORO-2'-DEOXYCYTIDINE
efgcjzvdhp(jhiteemxcb) = iknutmndjv xuzmkzakkm (qopvwbicrb, wiqyaxemje - haszyyxegg)
-
22 May 2020
Phase 2
95
tczkcfcumo(vaziawdzqd) = rxjrbkpjgm obyzjjzxdm (oojwyshlfe, garfjmwlai - fkompxnxyr)
-
27 Dec 2019
Phase 2
13
ayubydpbza(pbnpcxosmo) = erajecvdef ltwkiesngr (gpcksfhpvl )
Positive
01 Jun 2018
PBS
ayubydpbza(pbnpcxosmo) = czbelvncnt ltwkiesngr (gpcksfhpvl )
Phase 1
25
THU-decitabine
gbtllavhmf(towbfdjkpz) = uatmvcdszh uxqqlvbghh (adosqszqsn )
-
01 Sep 2017
Phase 1
-
qyvytnguth(dwmyidmnxl) = 100 mg/m2/day FdCyd with 350 mg/m2/day THU rervmzdshr (jyqslpztpa )
Positive
01 Mar 2015
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Approval

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Regulation

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