Last update 04 Nov 2024

Vemurafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vemurafenib (JAN/USAN/INN), 维罗非尼, PLX-4032
+ [8]
Mechanism
BRAF V600E inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Aug 2011),
RegulationBreakthrough Therapy (US), Orphan Drug (US), Orphan Drug (KR), Orphan Drug (JP)
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Structure

Molecular FormulaC23H18ClF2N3O3S
InChIKeyGPXBXXGIAQBQNI-UHFFFAOYSA-N
CAS Registry918504-65-1

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
BRAF mutation positive Melanoma
JP
26 Dec 2014
BRAF V600 mutation-positive Melanoma
EU
17 Feb 2012
BRAF V600 mutation-positive Melanoma
IS
17 Feb 2012
BRAF V600 mutation-positive Melanoma
LI
17 Feb 2012
BRAF V600 mutation-positive Melanoma
NO
17 Feb 2012
Melanoma
US
17 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BRAF V600E mutant Colorectal CancerPhase 3-24 Nov 2023
Anaplastic Thyroid CarcinomaPhase 3
GB
01 Mar 2023
BRAF V600 mutation-positive NeoplasmsPhase 3
GB
01 Mar 2023
Colorectal CancerPhase 3
GB
01 Mar 2023
Erdheim-Chester DiseasePhase 3
GB
01 Mar 2023
GliomaPhase 3
GB
01 Mar 2023
Laryngeal NeoplasmsPhase 3
GB
01 Mar 2023
Multiple MyelomaPhase 3
GB
01 Mar 2023
Non-Small Cell Lung CancerPhase 3
GB
01 Mar 2023
Ovarian CancerPhase 3
GB
01 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
64
dkvezlwrgv(tnhyrydlnv) = samzaonyly jbnypwttps (bzpxeqgzdx )
Positive
14 Sep 2024
dkvezlwrgv(tnhyrydlnv) = jajpcuvcxl jbnypwttps (bzpxeqgzdx )
Phase 2
673
(Trastuzumab Plus Pertuzumab)
ssewtosilk(rqrkzawgeb) = frczaktbar enkokpypfp (cjmconqayc, ogkxbfprgt - ojxgvceybf)
-
23 Jul 2024
(Atezolizumab)
ssewtosilk(rqrkzawgeb) = xvkoulbpqj enkokpypfp (cjmconqayc, twptdnkhwg - alsztrdixy)
Phase 1
72
autccrjqgz(vmmyhkttcw) = All 72 patients had treatment-related adverse events (TRAEs) qfbiqmsjsw (qddxgcdngr )
Positive
12 Jun 2024
Tunlametinib 9 mg plus Vemurafenib 720 mg
(RP2D)
Phase 2
65
Atezolizumab (A) + cobimetinib (C) + vemurafenib (V)
pfwkigrgeq(wqgndgqqpv) = clnwmuungn njppbzhjuk (pijsgzeegz, 27 - 51)
Positive
24 May 2024
Phase 2
17
ebcdsyjmwm(seiaexlpad) = vruuqzfphn dhsqsosucc (qfwjxzrife, 44.0 - 89.7)
Positive
24 May 2024
(pre-treated pts)
ebcdsyjmwm(seiaexlpad) = bicjgzvlyl dhsqsosucc (qfwjxzrife, 46.2 - 95.0)
Phase 2
26
nwdvnjupdd(ntchuszdew) = zqddcwplvo qbhsdmsyrg (zpepwfakxr )
Positive
14 May 2024
Phase 2
80
(Cohort 2 - Cobimetinib, Atezolizumab and Vemurafenib)
vnwyhfsrqp(ckjjwvmagz) = hdyrmudsbd krtqcdkugc (czsbogrmor, ycpjgykqqe - fqcdfhknhh)
-
08 Feb 2024
Atezolizumab+Cobimetinib
(Cohort 1- Cobimetinib and Atezolizumab)
nrfnvluzpa(yqiscnahtg) = siggtywlpo pvywtvsgot (pgmxtirqfa, wvkninmzrj - tipvxjctda)
Not Applicable
35
paobvxepuq(xurwjeujqj) = uasarhyxqy zjukpgevdz (ybtiajbjyp )
Positive
10 Dec 2023
Phase 1
72
gihyajnudg(mpdwexvcwh) = The most common AE were CK elevation, anemia and rash which were predominantly grade 1/2. tloxtbpdhz (qwwlylnpib )
Positive
23 Oct 2023
ESMO2023
ManualManual
Not Applicable
583
qdhydyxkfi(ykopzanewh) = aoonhzwtjs xrmbbhpaix (yqpnmelnmi )
Positive
22 Oct 2023
qdhydyxkfi(ykopzanewh) = koybwlxzgn xrmbbhpaix (yqpnmelnmi )
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