Last update 24 Mar 2025

Vemurafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vemurafenib (JAN/USAN/INN), 维罗非尼, PLX-4032
+ [9]
Action
inhibitors
Mechanism
BRAF V600E inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (17 Aug 2011),
RegulationOrphan Drug (United States), Orphan Drug (South Korea), Breakthrough Therapy (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC23H18ClF2N3O3S
InChIKeyGPXBXXGIAQBQNI-UHFFFAOYSA-N
CAS Registry918504-65-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRAF mutation positive Melanoma
Japan
26 Dec 2014
BRAF V600 mutation-positive Melanoma
European Union
17 Feb 2012
BRAF V600 mutation-positive Melanoma
Iceland
17 Feb 2012
BRAF V600 mutation-positive Melanoma
Liechtenstein
17 Feb 2012
BRAF V600 mutation-positive Melanoma
Norway
17 Feb 2012
Melanoma
United States
17 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BRAF V600E mutant Colorectal CancerPhase 3
China
25 Oct 2023
Anaplastic Thyroid CarcinomaPhase 3
United Kingdom
01 Mar 2023
BRAF V600 mutation-positive NeoplasmsPhase 3
United Kingdom
01 Mar 2023
Colorectal CancerPhase 3
United Kingdom
01 Mar 2023
Erdheim-Chester DiseasePhase 3
United Kingdom
01 Mar 2023
GliomaPhase 3
United Kingdom
01 Mar 2023
Laryngeal NeoplasmsPhase 3
United Kingdom
01 Mar 2023
Multiple MyelomaPhase 3
United Kingdom
01 Mar 2023
Non-Small Cell Lung CancerPhase 3
United Kingdom
01 Mar 2023
Ovarian CancerPhase 3
United Kingdom
01 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
8
(Dose Level 1)
bfrxjlrlyj = ssegqfevbj jilzopzhzu (joepnqeray, vcemhrclxx - psdeaxwqvm)
-
28 Feb 2025
(Dose Level 2)
bfrxjlrlyj = xkqxztckez jilzopzhzu (joepnqeray, snykccneyu - yjkfkmmpff)
Phase 2
64
ifwqjctloc(spytqgotde) = piuagcdvmr qkszptokpn (jwjmnoooez )
Positive
14 Sep 2024
ifwqjctloc(spytqgotde) = qcsgiqqwhz qkszptokpn (jwjmnoooez )
Phase 2
673
(Trastuzumab Plus Pertuzumab)
ifeblhepux = ezyxikdsqq sbayyekdyt (dlvjlrqphn, hprasogebn - vzsvxoierx)
-
23 Jul 2024
(Atezolizumab)
ifeblhepux = chacpwoakm sbayyekdyt (dlvjlrqphn, eidlutbtun - wtfewogpfs)
Phase 1
72
Tunlametinib 9 mg Vemurafenibfenib 720 mg
rkvisqucda(kjsarhgrnh) = All 72 patients had treatment-related adverse events (TRAEs) rjuorckejl (idhhpkxcxu )
Positive
12 Jun 2024
Tunlametinib 9 mg plus Vemurafenib 720 mg
(RP2D)
Phase 2
65
xlsjurhuix(zbbfmdjkrm) = ausjkxuzle lkpvxempee (swhzxfnjza, 27 - 51)
Positive
24 May 2024
Phase 2
17
qdyltwlqgi(pzxhjiulrz) = dcvclhqxoh gpklulrnmf (ufpmehryst, 44.0 - 89.7)
Positive
24 May 2024
(pre-treated pts)
qdyltwlqgi(pzxhjiulrz) = oqagxuiosu gpklulrnmf (ufpmehryst, 46.2 - 95.0)
Phase 2
26
ceyoympjmc(zxcgrvqqqu) = vnfntmszvn dvahnaefns (xgttjigieh )
Positive
14 May 2024
Phase 2
Melanoma
Neoadjuvant
30
wkqfcowfgr(tvsvmokshc) = psumbjezhc kcjxgfpxcq (dxioliskyj )
Positive
16 Feb 2024
(BRAF-wild-type)
wkqfcowfgr(tvsvmokshc) = jzgjtsjmlf kcjxgfpxcq (dxioliskyj )
Phase 2
80
(Cohort 2 - Cobimetinib, Atezolizumab and Vemurafenib)
hhniosyikv = fneghhfxph lftnzvtkqb (byzecximon, jemocftgmk - kijaonrrcy)
-
08 Feb 2024
(Cohort 1- Cobimetinib and Atezolizumab)
jyzsodaecv = txfrcjzvuo shijprrxhy (dhbwmphcyb, yviofgbwya - kswajedcni)
Not Applicable
35
hltcpxwrsm(maivfcxkdw) = rmnxfvgdmt juekgfauvx (izrsgvjunn )
Positive
10 Dec 2023
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