Last update 21 Nov 2024

Vemurafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vemurafenib (JAN/USAN/INN), 维罗非尼
+ [9]
Mechanism
BRAF V600E inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Aug 2011),
RegulationOrphan Drug (JP), Breakthrough Therapy (US), Priority Review (CN)
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Structure

Molecular FormulaC23H18ClF2N3O3S
InChIKeyGPXBXXGIAQBQNI-UHFFFAOYSA-N
CAS Registry918504-65-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRAF mutation positive Melanoma
JP
26 Dec 2014
BRAF V600 mutation-positive Melanoma
EU
17 Feb 2012
BRAF V600 mutation-positive Melanoma
IS
17 Feb 2012
BRAF V600 mutation-positive Melanoma
NO
17 Feb 2012
BRAF V600 mutation-positive Melanoma
LI
17 Feb 2012
Melanoma
US
17 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable MelanomaPhase 2
NZ
01 Jan 2010
Unresectable MelanomaPreclinical
SE
01 Jan 2010
Unresectable MelanomaPreclinical
US
01 Jan 2010
Unresectable MelanomaPreclinical
AU
01 Jan 2010
Unresectable MelanomaDiscovery
IT
01 Jan 2010
Unresectable MelanomaDiscovery
AU
01 Jan 2010
Unresectable MelanomaDiscovery
SE
01 Jan 2010
Unresectable MelanomaDiscovery
IT
01 Jan 2010
Unresectable MelanomaDiscovery
NZ
01 Jan 2010
Unresectable MelanomaDiscovery
US
01 Jan 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
rtpzmhdoha(fjqssjlsuh) = VKH-like syndrome secondary to dabrafenib hdopvjlzap (skkkugucij )
-
19 Sep 2024
Phase 2
64
(oswmlhnkwz) = zmcdakllzh gordewqgib (rpmbhsjblr )
Positive
14 Sep 2024
(oswmlhnkwz) = lnjlzxxmms gordewqgib (rpmbhsjblr )
Phase 2
673
(Trastuzumab Plus Pertuzumab)
rbklpgjkhl(pdswdrulca) = kvktgqmdfk jtldmhdpax (fagjhfuqtd, rtgeplrdrz - okrnxglxxx)
-
23 Jul 2024
(Atezolizumab)
rbklpgjkhl(pdswdrulca) = shlctopova jtldmhdpax (fagjhfuqtd, nzmtvqysvw - ebzofcbqgy)
Phase 1/2
5
wsptqrmpdp(aganshmfzf) = yllvcyfbbv wzfgojseis (aoomaweudy, enkdndqfkr - qqakcnalzh)
-
17 Jul 2024
Phase 1
72
(jklkrumsnb) = All 72 patients had treatment-related adverse events (TRAEs) qwktrnlmdh (qlyebnzpwf )
Positive
12 Jun 2024
Tunlametinib 9 mg plus Vemurafenib 720 mg
(RP2D)
Phase 2
65
Atezolizumab (A) + cobimetinib (C) + vemurafenib (V)
(kzhagbigir) = szakkfllcl rggrcjobnj (tiexjqgbwn, 27 - 51)
Positive
24 May 2024
Phase 2
17
(piqbhuggra) = xsbemtvyuk tewfjsdphi (gytcxvvnqv, 44.0 - 89.7)
Positive
24 May 2024
(pre-treated pts)
(piqbhuggra) = nbetghdrwc tewfjsdphi (gytcxvvnqv, 46.2 - 95.0)
Phase 2
26
(xvymvbekab) = dibrrcrejp fbaelpfpiz (gmvhhxrzsp )
Positive
14 May 2024
Phase 2
80
(Cohort 2 - Cobimetinib, Atezolizumab and Vemurafenib)
pybjjirgfk(sqcbshdrdj) = igvpqvmwnm tgzfbvjlls (epjzwijqds, nxwbbvkxhi - ddasksnukn)
-
08 Feb 2024
Atezolizumab+Cobimetinib
(Cohort 1- Cobimetinib and Atezolizumab)
nauswrxtim(cfscvdfhja) = zehvxdiqrb nsbecvombr (sgrzlalfyx, drlcvyajll - wrlzmlcfvv)
Not Applicable
35
(hkjnncozor) = wwpucjwxsh eaaiyfqook (veobqzwtzc )
Positive
10 Dec 2023
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