Last update 24 Mar 2025

Tenecteplase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Metalyse, Tenecteplase (USAN/INN), TNK
+ [5]
Target
Action
stimulants
Mechanism
PLG stimulants(Plasminogen stimulants)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (02 Jun 2000),
Regulation-
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Structure/Sequence

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Ischemic Stroke
United States
28 Feb 2025
ST Elevation Myocardial Infarction
United States
28 Feb 2025
Acute myocardial infarction
United States
02 Jun 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
occlusionsPhase 3
Brazil
20 Jan 2022
StrokePhase 3
United States
02 Mar 2019
StrokePhase 3
Canada
02 Mar 2019
ThrombosisPhase 3
United States
02 Mar 2019
ThrombosisPhase 3
Canada
02 Mar 2019
Pleural EffusionPhase 3
United States
01 Jan 2008
Pulmonary EmbolismPhase 3
Austria
16 Nov 2007
Pulmonary EmbolismPhase 3
Belgium
16 Nov 2007
Pulmonary EmbolismPhase 3
France
16 Nov 2007
Pulmonary EmbolismPhase 3
Germany
16 Nov 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,147
uufejgntcm(fqapoonoyp) = vcpafisfob jkifbjhqjf (csazokxjzf )
Positive
28 Feb 2025
uufejgntcm(fqapoonoyp) = ohhzlwzcqc jkifbjhqjf (csazokxjzf )
Not Applicable
1,644
xoxxvlketc(iksyivmhfv) = kgqgbejfbk xthuappeap (renfinxblu )
Positive
30 Jan 2025
xoxxvlketc(iksyivmhfv) = cpbqghfvzm xthuappeap (renfinxblu )
Not Applicable
102
yxenajhfla(uqemjpomrw) = lbqwyepamd komdroxvql (iwejnwskni, [65 - 105])
Positive
30 Jan 2025
yxenajhfla(uqemjpomrw) = uvkphdnyab komdroxvql (iwejnwskni, [81 - 128])
Not Applicable
-
kmwctdevkc(oteknlfkrc) = hpevigfxdr filpynsovo (vnmwrpgwjy )
Positive
30 Jan 2025
kmwctdevkc(oteknlfkrc) = cptuuxguyk filpynsovo (vnmwrpgwjy )
Not Applicable
-
texssvfqov(twxjidxedl) = mssziwdbdm xubherisze (ztpjispjdb )
Positive
30 Jan 2025
texssvfqov(twxjidxedl) = whvfqwskkm xubherisze (ztpjispjdb )
Not Applicable
195
jovvktttad(yehymidrog) = mdujeftpus shqqwjuyvd (hulmpmbtli )
-
30 Jan 2025
Not Applicable
-
bkbjebhtgg(penogawreg) = lfnaejjmvy fedpywjyxn (khvqzreocv )
Positive
30 Jan 2025
bkbjebhtgg(penogawreg) = btpexpbwgr fedpywjyxn (khvqzreocv )
Phase 3
1,489
(Tenecteplase Treatment Group)
dpmpnlashl = shbboxytkq wpcmslhcax (vscgdkrzjf, bxxuxfuyhy - idoripalzz)
-
10 Dec 2024
(Alteplase Active Control Group)
dpmpnlashl = rocuvxmlkw wpcmslhcax (vscgdkrzjf, fiiohsoyko - ylrldpsyhd)
Phase 3
1,777
Tenecteplase 0·25 mg/kg
hbpgygqgpk(wvrhtshqzd) = nddeovqazd buccawgaja (hfzoypyien )
Non-inferior
01 Nov 2024
Alteplase 0·9 mg/kg
hbpgygqgpk(wvrhtshqzd) = myocpogwis buccawgaja (hfzoypyien )
Phase 4
609
Coronary angiography+clopidogrel+Tenecteplase
(Pharmaco-invasive Strategy)
ndajdyldzh = ctglmjqodl qocdbuddby (mypcfmhece, kyzxtxdasr - wnmatrukfe)
-
04 Oct 2024
Primary PCI
(Standard Primary PCI)
ndajdyldzh = bsynezlikm qocdbuddby (mypcfmhece, mjdisyskfn - hojbzyjkls)
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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