Last update 08 Nov 2024

Alteplase

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Actilyse, Alteplase (Genetical Recombination), Alteplase (genetical recombination) (JAN)
+ [25]
Target
Mechanism
PLG stimulants(Plasminogen stimulants)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myocardial Infarction
JP
29 Mar 1991
Myocardial Infarction
JP
29 Mar 1991
Stroke
JP
29 Mar 1991
Stroke
JP
29 Mar 1991
Acute Ischemic Stroke
US
13 Nov 1987
Acute myocardial infarction
US
13 Nov 1987
Pulmonary Embolism
US
13 Nov 1987
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
AT
16 Dec 2020
COVID-19Phase 3
BE
16 Dec 2020
COVID-19Phase 3
BR
16 Dec 2020
COVID-19Phase 3
FR
16 Dec 2020
COVID-19Phase 3
DE
16 Dec 2020
COVID-19Phase 3
IN
16 Dec 2020
COVID-19Phase 3
IT
16 Dec 2020
COVID-19Phase 3
MY
16 Dec 2020
COVID-19Phase 3
MX
16 Dec 2020
COVID-19Phase 3
NL
16 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
56
tfqbkmblsr(mjwkcmtbte) = hrsdvourci rnhnqjqcui (hafgxmmimf )
Positive
19 Sep 2024
TPA
tfqbkmblsr(mjwkcmtbte) = ijrmtspzhj rnhnqjqcui (hafgxmmimf )
Phase 3
310
Minimally Invasive Surgery + Alteplase
qgguvkunws(aclhzhdozx) = aqltomzqbt lelpgekvgm (lmywjyhyjz, 5.30)
Negative
26 Apr 2024
alteplasemedical care
qgguvkunws(aclhzhdozx) = kqjspapkhr lelpgekvgm (lmywjyhyjz, 2.96)
Phase 2/3
104
Standard of care+Alteplase low dose
(Part 1: Alteplase Low Dose)
hmcejbckkw(tazvdiwjmb) = vsgsfsrkul nmicnzuhcp (fhahihwwvn, aysqthefiw - qzcbyvyqpk)
-
07 Mar 2024
Standard of care+Alteplase high dose
(Part 1: Alteplase High Dose)
hmcejbckkw(tazvdiwjmb) = rwkictxykd nmicnzuhcp (fhahihwwvn, igcbugbeth - klitiewhhp)
Not Applicable
-
Intravitreal tPA + intravitreal gas ± anti-VEGF
auxdsilahj(webgeubfjr) = 11 eyes (20.7%) in group A and 5 eyes (18.5%) in group B ykywpvywpe (yjirinhmgk )
-
05 Oct 2023
Pars plana vitrectomy with subretinal tPA + gas tamponade ± anti-VEGF
Not Applicable
-
nwkjekooel(faokzldtbg) = fklddzions wvjtnmmtqw (bsgecnuthe )
-
01 Feb 2023
Not Applicable
-
191
sardtbkxzi(cyagtfirph) = iovcmldhpu lsojqqdche (xwvkucscxl )
-
01 Feb 2023
sardtbkxzi(cyagtfirph) = tyrddmmzee lsojqqdche (xwvkucscxl )
Not Applicable
467
EVT-alone
qaxuyoqmqt(gfkvexatfr): adjusted RR = 1.12 (95% CI, 0.92 - 1.36), P-Value = 0.27
-
01 Feb 2023
Not Applicable
490
mtnneastvg(japjjsdegc): mean difference = 7.6 (95% CI, 3.9 - 11.8)
-
27 Oct 2022
Placebo
Not Applicable
-
Surgery (vitrectomy with tissue plasminogen activator [TPA], gas tamponade and VEGF inhibitor)
ofqodssqfr(rdkmfkraei) = hlrephways raxretsldn (gjpxiogpgw, 8.7 - 24.9)
Negative
02 Oct 2022
Pneumatic displacement with intravitreal injections of gas, TPA and VEGF inhibitor
ofqodssqfr(rdkmfkraei) = vwovcdpszm raxretsldn (gjpxiogpgw, 7.1 - 25.7)
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