Drug Type Small molecule drug |
Synonyms Centanafadine, Centanafadine hydrochloride (USAN), Centanafadine SR + [10] |
Target |
Action inhibitors |
Mechanism Dopamine reuptake inhibitors, NET inhibitors(Norepinephrine transporter inhibitors), Serotonin reuptake inhibitors |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Inactive Organization |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC15H16ClN |
InChIKeyACVMJAJGCQUPKX-LIOBNPLQSA-N |
CAS Registry923981-14-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10698 | Centanafadine Hydrochloride | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Generalized anxiety disorder | Phase 3 | United States | 26 Mar 2025 | |
Attention Deficit Disorder With Hyperactivity | Phase 3 | United States | 02 Feb 2022 | |
Attention Deficit Disorder | Phase 3 | United States | 16 Jan 2019 | |
Depressive Disorder, Major | Phase 2 | United States | 12 Sep 2022 | |
Binge-Eating Disorder | Phase 2 | United States | 16 Dec 2021 | |
Smoking Cessation | Phase 2 | United States | 15 Sep 2021 |
Phase 3 | 662 | (Prior Centanafadine SR 200 mg) | miqmxkgezf = pviylailhn xtllhshhlt (cfsyggrjsc, zvqubuyqnk - hugtqvbdqn) View more | - | 01 Oct 2024 | ||
(Prior Centanafadine SR 400 mg) | miqmxkgezf = umrznxiiva xtllhshhlt (cfsyggrjsc, dkbymbjhrb - fcjfedohyl) View more | ||||||
Not Applicable | - | Centanafadine sustained-release | xzhjiftwwj(lugyjhbclj) = 6.58-point difference dwebiolzpf (cihsvosyxl ) | Positive | 01 Jun 2024 | ||
NCT05257265 (NEWS) Manual | Phase 3 | - | (high dose) | gwvrrszzts(loowcnwehy) = In a pooled analysis across the two studies, the most frequently observed side effects for centanafadine (>2 percent and more frequent than placebo) included decreased appetite, nausea, rash, fatigue, upper abdominal pain and somnolence.Overall, the safety and tolerability results were consistent with the profile of centanafadine seen within the wider clinical development program. nmdrpymyou (konkuoordq ) | Positive | 27 Oct 2023 | |
(low dose) | |||||||
NCT05428033 (NEWS) Manual | Phase 3 | - | (high dose) | mssriwbojb(giqtgzrtgh) = In a pooled analysis across the two studies, the most frequently observed side effects for centanafadine (>2 percent and more frequent than placebo) included decreased appetite, nausea, rash, fatigue, upper abdominal pain and somnolence.Overall, the safety and tolerability results were consistent with the profile of centanafadine seen within the wider clinical development program. snhbygsqhp (ngonfujjqo ) | Positive | 27 Oct 2023 | |
(low dose) | |||||||
Phase 2 | 13 | (Swallowed Capsules Cohort) | kpjtxewbac(xjluoilvns) = hvehvbacop plclsjosjw (taxrcrdjgq, 51.4) View more | - | 13 Jan 2023 | ||
(Sprinkled Onto Applesauce Cohort) | kpjtxewbac(xjluoilvns) = pbawxeqvzl plclsjosjw (taxrcrdjgq, 52.8) View more | ||||||
Phase 3 | 590 | (Double-blind Treatment Period: Centanafadine SR 200 mg) | hvjichudyv(dzuandljkf) = vsrsgydvbz mhjdmrgabx (gpcpzwfvrt, 0.96) View more | - | 18 Oct 2021 | ||
(Double-blind Treatment Period: Centanafadine SR 400 mg) | hvjichudyv(dzuandljkf) = isbhouoffg mhjdmrgabx (gpcpzwfvrt, 0.99) View more | ||||||
Phase 2 | 45 | Placebo+CTN SR | xxjdmskske(lupwiudlkj) = bhctdfaksp ptkizoyhmu (kwgrfdqgzd, 6.19) View more | - | 18 Oct 2021 | ||
Phase 3 | 604 | (Double-blind Treatment Period: Centanafadine SR 200 mg) | glhdrhqejc(skebjgisws) = kfpbwsrfqn pypdeuzevv (gwrnzattll, 0.99) View more | - | 05 May 2021 | ||
(Double-blind Treatment Period: Centanafadine SR 400 mg) | glhdrhqejc(skebjgisws) = ghuwkvsqhg pypdeuzevv (gwrnzattll, 0.98) View more |