
Introduction Otsuka Holdings Co., Ltd., based in Tokyo, Japan, manages a group of companies involved in the pharmaceutical business. The company's operations are divided into Pharmaceuticals, Nutraceuticals, Consumer Products, and Other segments. Pharmaceuticals focus on manufacturing therapeutic drugs for diseases related to the central nervous system, oncology, and infections. Nutraceuticals develop and sell nutritional products, including food, health drinks, and dietary supplements. Consumer products include mineral water, food, and beverages. The additional segment offers functional and fine chemicals, optical inspection devices, and clinical diagnosis equipment. The company was established on July 8, 2008. |
| Top 5 Drug Type | Count |
|---|---|
| Small molecule drug | 132 |
| Monoclonal antibody | 11 |
| Antibody drug conjugate (ADC) | 8 |
| Chemical drugs | 4 |
| Diagnostic radiopharmaceuticals | 3 |
Target |
Mechanism Dopamine reuptake inhibitors [+2] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date24 Jul 2026 |
Target |
Mechanism APRIL inhibitors |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date25 Nov 2025 |
Target |
Mechanism KLKB1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. United States |
First Approval Date21 Aug 2025 |
Start Date01 Jun 2027 |
Sponsor / Collaborator |
Start Date15 Dec 2026 |
Sponsor / Collaborator |
Start Date01 Dec 2026 |
Sponsor / Collaborator |

| Drug(Targets) | Indications | Global Highest Phase |
|---|---|---|
Aripiprazole ( 5-HT1A receptor x 5-HT2A receptor x D2 receptor x D3 receptor ) | Schizophrenia More | Approved |
Futibatinib ( FGFR1 x FGFR2 x FGFR3 x FGFR4 ) | FGFR2 fusion or rearranged Cholangiocarcinoma More | Approved |
Brexpiprazole ( 5-HT1A receptor x 5-HT2A receptor x D2 receptor ) | Schizophrenia More | Approved |
Tolvaptan ( AVPR2 ) | Polycystic Kidney, Autosomal Dominant More | Approved |
Decitabine/Cedazuridine ( CDA x DNMT1 ) | Myelodysplastic Syndromes More | Approved |





