Last update 01 Nov 2024

Moxidectin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milbemycin B, Moxidectin (USP/INN)
+ [1]
Target
Mechanism
Glutamate-gated chloride channel modulators
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (13 Jun 2018),
RegulationOrphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC37H53NO8
InChIKeyYZBLFMPOMVTDJY-UHFFFAOYSA-N
CAS Registry113507-06-5

External Link

KEGGWikiATCDrug Bank
D05084Moxidectin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Onchocerciasis
US
13 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Elephantiasis, FilarialPhase 3
CG
03 May 2021
Elephantiasis, FilarialPhase 3
CI
03 May 2021
OnchocerciasisPhase 3
CG
01 Apr 2009
OnchocerciasisPhase 2
GH
01 Apr 2009
OnchocerciasisPhase 2
LR
01 Apr 2009
OnchocerciasisPhase 1
LR
01 Apr 2009
OnchocerciasisPhase 1
GH
01 Apr 2009
ScabiesDiscovery
AT
13 Jan 2020
ScabiesDiscovery
FR
13 Jan 2020
ScabiesDiscovery
AU
13 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
332
(Moxidectin)
iwjxmdrslg(dzmktlgxdi) = jyzlycwphk wurehbajnr (fnphirssbd, biuotqwoxf - zeivsfulpc)
-
24 Jan 2024
(Ivermectin)
iwjxmdrslg(dzmktlgxdi) = pveozotlde wurehbajnr (fnphirssbd, yappqtpdra - zpoqkrgopx)
Phase 2
22
(Moxidectin 2 mg)
ctmrnonejo(qqgxezaapw) = czxhubpdud atcunltwjt (mkegqqltun, jejeozhfei - pnjovknkml)
-
22 Sep 2023
(Moxidectin 8 mg)
ctmrnonejo(qqgxezaapw) = dznecvaptb atcunltwjt (mkegqqltun, xnmftmgqjz - drftfsfpit)
Phase 3
Elephantiasis, Filarial
Wuchereria bancrofti microfilaremia
-
(yiaxnpcgym) = Four participants had transient Grade 3 hematuria after treatment (3 after IDA and 1 after IA) ztwxytstoy (xldscxwlgt )
Positive
18 Sep 2023
Phase 3
255
xrquaxidmx(xjfmyggeaq) = awxlqqzckc xspcldbgbt (myteanpdif, lmaslarkzb - pvchiruiul)
-
02 Feb 2023
(Arm B: Albendazole)
xrquaxidmx(xjfmyggeaq) = nmeiryvuqg xspcldbgbt (myteanpdif, qzwgihnmcd - xsagzlhljs)
Phase 3
1,497
oltxwaosbq(tlbnwlbqso) = jknbrejbcj zyqrvfosjm (xhzmcebjkb )
Positive
27 Apr 2022
oltxwaosbq(tlbnwlbqso) = fpzepjcxux zyqrvfosjm (xhzmcebjkb )
Phase 2
96
(btttebzfal) = indvtuukih riehrwpjsv (obpzjtolfe, 3.63 - 5.39)
-
23 Jul 2021
Phase 1
60
(Moxidectin 4mg)
narbgzboaf(ughlgootab) = mmpsoljobl udgununrqk (mikthagtti, utmqnndswb - jjhtpsdnyk)
-
14 Mar 2019
(Moxidectin 8mg)
narbgzboaf(ughlgootab) = datokuvfmi udgununrqk (mikthagtti, zrbmgkubmp - ndicwzyxsf)
Phase 2
172
(dxkrzrqbtz) = ffrxfdwuvh hjbhqsaxqx (knvvztynvv )
-
01 Jun 2014
(dxkrzrqbtz) = uxamtpqfne hjbhqsaxqx (knvvztynvv )
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Regulation

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