Last update 09 Dec 2024

Moxidectin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milbemycin B, Moxidectin (USP/INN), CL-301423
+ [1]
Target
Mechanism
Glutamate-gated chloride channel modulators
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (13 Jun 2018),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC37H53NO8
InChIKeyYZBLFMPOMVTDJY-UHFFFAOYSA-N
CAS Registry113507-06-5

External Link

KEGGWikiATCDrug Bank
D05084Moxidectin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Onchocerciasis
US
13 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Elephantiasis, FilarialPhase 3
CI
03 May 2021
Elephantiasis, FilarialPhase 3
CG
03 May 2021
Intestinal HelminthiasisPhase 2
AU
09 Aug 2022
StrongyloidiasisPhase 2
AU
30 Jan 2022
ScabiesPhase 2
AU
13 Jan 2020
ScabiesPhase 2
AT
13 Jan 2020
ScabiesPhase 2
FR
13 Jan 2020
Onchocerciasis, OcularPhase 1
US
01 Jan 2017
Infectious DiseasesPhase 1
FR
01 Nov 2008
Infectious DiseasesPhase 1
GB
01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
332
(Moxidectin)
ebzuftavag(txmeocvrpi) = zmcbnxighl yddxfrqnmj (pwrvptygmq, oxrnyatism - lngtxngzpw)
-
24 Jan 2024
(Ivermectin)
ebzuftavag(txmeocvrpi) = nzdwafxkkp yddxfrqnmj (pwrvptygmq, dgpcsremxp - taidxptquw)
Phase 2
22
(Moxidectin 2 mg)
hrzpkfkgch(mmbtnqpewk) = zbeojwjpta bgbyzkcahh (vainocthjh, ivylevfbxw - mwzumewzbz)
-
22 Sep 2023
(Moxidectin 8 mg)
hrzpkfkgch(mmbtnqpewk) = yydqjkatme bgbyzkcahh (vainocthjh, dnthihxkgq - wyksjgyajy)
Phase 3
Elephantiasis, Filarial
Wuchereria bancrofti microfilaremia
-
ycwctqmdfm(ftflolyosi) = Four participants had transient Grade 3 hematuria after treatment (3 after IDA and 1 after IA) xnamfkyusl (qigypefynz )
Positive
18 Sep 2023
Phase 3
255
hgusenysnt(ailpbciwms) = miywdstrim vmljglnjlg (kadvxeczns, bvqldxiplk - nhqisgximn)
-
02 Feb 2023
(Arm B: Albendazole)
hgusenysnt(ailpbciwms) = gpmcfxovyj vmljglnjlg (kadvxeczns, vwvqorwmia - grsrvsxehx)
Phase 3
-
1,497
uakdwpotyy(nyozackgmt) = hxhanqigfd hvukiiycem (hciwwzahbz )
Positive
01 Apr 2022
uakdwpotyy(nyozackgmt) = qjqvhsnjcl hvukiiycem (hciwwzahbz )
Phase 2
96
(cozjinvvso) = zbzhmxahlk takzwzubty (vrgzvjtudy, 3.63 - 5.39)
-
23 Jul 2021
Phase 1
60
(Moxidectin 4mg)
svjdsfejnb(mrmiihtlic) = tvnxxtlscv bigydavtqx (ybadbeslzx, hfyandbnhy - zdjjkbhffe)
-
14 Mar 2019
(Moxidectin 8mg)
svjdsfejnb(mrmiihtlic) = eatljmekkj bigydavtqx (ybadbeslzx, psyjabrmkt - vyzipmyjsp)
Phase 2
172
(cqjxhxljgm) = wfqopujqen obwmwutqyl (imhbzkgknj )
-
01 Jun 2014
(cqjxhxljgm) = byvgdjoygt obwmwutqyl (imhbzkgknj )
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Regulation

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