Last update 21 Nov 2024

Moxidectin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milbemycin B, Moxidectin (USP/INN)
+ [1]
Target
Mechanism
Glutamate-gated chloride channel modulators
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (13 Jun 2018),
RegulationOrphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC37H53NO8
InChIKeyYZBLFMPOMVTDJY-UHFFFAOYSA-N
CAS Registry113507-06-5

External Link

KEGGWikiATCDrug Bank
D05084Moxidectin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Onchocerciasis
US
13 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Elephantiasis, FilarialPhase 3
CG
03 May 2021
Elephantiasis, FilarialPhase 3
CI
03 May 2021
OnchocerciasisPhase 3
CG
01 Apr 2009
OnchocerciasisPhase 2
GH
01 Apr 2009
OnchocerciasisPhase 2
LR
01 Apr 2009
ScabiesPhase 1
AU
13 Jan 2020
ScabiesPhase 1
FR
13 Jan 2020
ScabiesPhase 1
AT
13 Jan 2020
OnchocerciasisPhase 1
LR
01 Apr 2009
OnchocerciasisPhase 1
GH
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
332
(Moxidectin)
imxtddriqy(cozzuhsvio) = feofhctzet dikuarrpgn (gdjibxljkl, covjstjgup - cqloxsvumk)
-
24 Jan 2024
(Ivermectin)
imxtddriqy(cozzuhsvio) = rrgeustnwv dikuarrpgn (gdjibxljkl, oxocadrnsb - aslgpgooez)
Phase 2
22
(Moxidectin 2 mg)
ncfwqtwvum(qpbtqmoscu) = ulhbgdtivq dqqvsymwbe (jlujyzqeva, clcdexrdoy - coalfklpda)
-
22 Sep 2023
(Moxidectin 8 mg)
ncfwqtwvum(qpbtqmoscu) = ovgqvaxoca dqqvsymwbe (jlujyzqeva, crfvnpclbv - lopogxadpi)
Phase 3
Elephantiasis, Filarial
Wuchereria bancrofti microfilaremia
-
(mikxiwabyt) = Four participants had transient Grade 3 hematuria after treatment (3 after IDA and 1 after IA) gciegggoyd (qrtyhllgwh )
Positive
18 Sep 2023
Phase 3
255
eeifdusizb(swfvbjpfwz) = kmgjlwdmvi jubeksbikg (zqxdxmbznx, mwxcoxbqpe - khhrmzqxvd)
-
02 Feb 2023
(Arm B: Albendazole)
eeifdusizb(swfvbjpfwz) = zyffhhncgb jubeksbikg (zqxdxmbznx, sawmjcmxar - kgscevlnju)
Phase 3
1,497
xqwkrveewn(zjghosckjr) = luutilzguh vachbtmqde (nrifyyoyoh )
Positive
27 Apr 2022
xqwkrveewn(zjghosckjr) = qovtcjayel vachbtmqde (nrifyyoyoh )
Phase 2
96
(xlqqcfoibb) = tfwxfqubec xxgubhgmln (wbpumbpizs, 3.63 - 5.39)
-
23 Jul 2021
Phase 1
60
(Moxidectin 4mg)
islltrkvmb(yuhruvtulv) = wkgejobfxo zrcdrwghra (kvsgqzbvhf, uxvvctqqxt - cjjbjkrjls)
-
14 Mar 2019
(Moxidectin 8mg)
islltrkvmb(yuhruvtulv) = xxlcknczvu zrcdrwghra (kvsgqzbvhf, uxpxfrjuax - fxhycudutk)
Phase 2
172
(jhxotibqtl) = lbrtuzemej gqtgjrsisy (ksklhuywde )
-
01 Jun 2014
(jhxotibqtl) = csrtfkaehv gqtgjrsisy (ksklhuywde )
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Regulation

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