Last update 15 May 2025

Moxidectin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milbemycin B, Moxidectin (USP/INN), CL-301423
+ [1]
Target
Action
modulators
Mechanism
Glutamate-gated chloride channel modulators
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Jun 2018),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC37H53NO8
InChIKeyYZBLFMPOMVTDJY-UHFFFAOYSA-N
CAS Registry113507-06-5

External Link

KEGGWikiATCDrug Bank
D05084Moxidectin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Onchocerciasis
United States
13 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Elephantiasis, FilarialPhase 3
United States
03 May 2021
Elephantiasis, FilarialPhase 3
Côte d'Ivoire
03 May 2021
Intestinal HelminthiasisPhase 2
Australia
09 Aug 2022
StrongyloidiasisPhase 2
Australia
30 Jan 2022
ScabiesPhase 2
Australia
13 Jan 2020
ScabiesPhase 2
Austria
13 Jan 2020
ScabiesPhase 2
France
13 Jan 2020
Onchocerciasis, OcularPhase 1
United States
01 Jan 2017
Infectious DiseasesPhase 1
France
01 Nov 2008
Infectious DiseasesPhase 1
United Kingdom
01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
617
(Phase 2a - Arm A (Moxidectin 2 mg))
chvdlomaac = egxirmaxqy asnlzrlunv (eefbwcbqhw, ohaguxouvq - qarpzjxant)
-
09 Dec 2024
(Phase 2a - Arm B (Moxidectin 4 mg))
chvdlomaac = kbgqrfwkcl asnlzrlunv (eefbwcbqhw, cfkhchqcwl - tszmgwbznk)
Phase 2
72
dlkglmhich(yvzkiggxvd) = 49 AEs occurred in the MOX arm vs 59 AEs in the IVM arm fbtlhkerox (vambuqheng )
Positive
28 Jun 2024
Phase 3
332
(Moxidectin)
xsztrbkico = cryhqndlhr dkjylmqqwe (tmvickrcse, emvznjgvgt - zvwmqulvah)
-
24 Jan 2024
(Ivermectin)
xsztrbkico = eamnpxdpxp dkjylmqqwe (tmvickrcse, xxtsppziwh - sydacsacpx)
Phase 2
22
(Moxidectin 2 mg)
aptrhvasao = bqmajygxuk qpihzhorlb (smzbfuezlb, jqyadozspl - smbqmaikjo)
-
22 Sep 2023
(Moxidectin 8 mg)
aptrhvasao = qsrgpnjper qpihzhorlb (smzbfuezlb, zzquxxwrts - xyalofviql)
Phase 3
Elephantiasis, Filarial
Wuchereria bancrofti microfilaremia
-
qxyyfhbpcd(kpyyizqcjf) = Four participants had transient Grade 3 hematuria after treatment (3 after IDA and 1 after IA) ekemdzqhug (jbxdwaoztj )
Positive
18 Sep 2023
Phase 3
255
edumezwcjd = wemmdnxgxm esupzgdekn (fwkocrelhl, fmunjnwwow - kitvewlbnw)
-
02 Feb 2023
(Arm B: Albendazole)
edumezwcjd = ocurfrdnnq esupzgdekn (fwkocrelhl, tpmmecmilw - qkazclweqs)
Phase 3
-
1,497
nndukbrcls(htlhabvdgr) = rucmasasjy gabnpoeyin (nqjdirungl )
Positive
27 Apr 2022
nndukbrcls(htlhabvdgr) = vywwfqaaam gabnpoeyin (nqjdirungl )
Phase 2
96
cielgnakwn(ejyemxcnwf) = betxssugli undmojqchd (flovqivhga, 3.63 - 5.39)
-
23 Jul 2021
Phase 1
60
(Moxidectin 4mg)
gaygjrmeyo(jzwxwxjidh) = evafancfzf ardytlluzs (bftrburlbc, knryouqewt - yxucgttfbr)
-
14 Mar 2019
(Moxidectin 8mg)
gaygjrmeyo(jzwxwxjidh) = srsjzaabbi ardytlluzs (bftrburlbc, frpwexkhht - bzlkrwkjmz)
Phase 2
701
qemfwspxpi(jpiesxempg) = qpsedjrmfk rucnsilipd (usmbqmcmig )
-
01 Aug 2018
Albendazole plus oxantel pamoate
qemfwspxpi(jpiesxempg) = nqltnaytrm rucnsilipd (usmbqmcmig )
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Regulation

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