Last update 24 Jul 2024

Niclosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FW-CD, FW-COV, FW-ICI-AC
+ [24]
Target
Mechanism
AR-v7 inhibitors(androgen receptor splice variant 7 inhibitors), Mitochondrial oxidative phosphorylation uncouplers
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-

Structure

Molecular FormulaC13H10Cl2N2O5
InChIKeyZBXRPLQCPHTHLM-UHFFFAOYSA-N
CAS Registry73360-56-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ascariasis
US
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
US
30 Jan 2022
Diabetic NephropathiesPhase 3
EG
01 Feb 2020
Gastrointestinal infectionPhase 2
US
30 Apr 2021
Gastrointestinal infectionPhase 2
IN
30 Apr 2021
Gastrointestinal infectionPhase 2
UA
30 Apr 2021
ProctocolitisPhase 2
IT
15 May 2018
Ulcerative proctitisPhase 2
IT
15 May 2018
Crohn DiseasePhase 1--
DiarrheaPreclinical
US
15 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
166
(Niclosamide)
nrfvaazrxo(biiqnaspej) = wnmvkqidqj txilykpvss (tchxtmabut, aahjgiloow - bbicvojytb)
-
24 Jul 2024
Placebo
(Placebo)
nrfvaazrxo(biiqnaspej) = dcixhwsxqr txilykpvss (tchxtmabut, vppddyulwd - ftvkqvhnch)
Phase 3
60
sxzhjluqqu(rnbksdhvry) = zgyeuhyiwy bzedowqtip (inwfmwtrij, -30to-18.3)
Positive
16 Feb 2023
sxzhjluqqu(rnbksdhvry) = velzoduyxh bzedowqtip (inwfmwtrij, 4to18.2)
Phase 2
73
yeiwnovvto(rskftatwhd) = mcrxpeldhe ppxjpjigqk (iyqzvidpxs, 50.74 - 81.81)
Negative
01 Feb 2022
Placebo
yeiwnovvto(rskftatwhd) = ucrblcxjge ppxjpjigqk (iyqzvidpxs, 40.27 - 72.73)
Phase 2
6
ofgzygsmjw(laowjyerwn) = two with partial PSA response (≥50% decrease) zxfbnbqltq (mkhhhoypnv )
Positive
01 Jun 2018
Not Applicable
-
fdmfvpwygw(xkwoxlantf) = I/R-induced fatty acid deposition in tubular epithelium was almost diminished in niclosamide-treated mice pozdveppmk (zojknsfsbu )
Positive
15 Nov 2016
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Regulation

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