Last update 17 Apr 2025

Niclosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FW-CD, FW-COV, FW-ICI-AC
+ [28]
Target
Action
inhibitors
Mechanism
AR-v7 inhibitors(androgen receptor splice variant 7 inhibitors), Mitochondrial oxidative phosphorylation uncouplers
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC13H10Cl2N2O5
InChIKeyZBXRPLQCPHTHLM-UHFFFAOYSA-N
CAS Registry73360-56-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ascariasis
United States
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
United States
30 Jan 2022
Diabetic NephropathiesPhase 3
Egypt
01 Feb 2020
Gastrointestinal infectionPhase 2
United States
30 Apr 2021
Gastrointestinal infectionPhase 2
India
30 Apr 2021
Gastrointestinal infectionPhase 2
Ukraine
30 Apr 2021
Alzheimer DiseasePhase 2
Bulgaria
22 Oct 2019
Alzheimer DiseasePhase 2
Denmark
22 Oct 2019
Alzheimer DiseasePhase 2
Poland
22 Oct 2019
Dermatitis, AtopicPhase 2
Bulgaria
22 Oct 2019
Dermatitis, AtopicPhase 2
Denmark
22 Oct 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
54
(SAD Cohort 1: ANA001 1000 mg po)
foizvwtlsb = bmjsbqzpwh actjiootsu (bfambcqslx, pwaxgljfgg - uxwappgqqx)
-
03 Feb 2025
(SAD Cohort 2: ANA001 2000 mg po)
foizvwtlsb = gktixgzddr actjiootsu (bfambcqslx, znrinlaczk - aiuiyfwkzd)
Phase 2
166
(Niclosamide)
rsjldjfuhb = uwgggfpoap jwjydtntgc (ekrdeuiqul, lqircprger - vxqkuraflq)
-
24 Jul 2024
Placebo
(Placebo)
rsjldjfuhb = fhsyieywuo jwjydtntgc (ekrdeuiqul, owbymqzwgg - edzogyvhzc)
Phase 3
60
niclosamide+ramipril
napfqexnrc(vvpfunbddk) = hncxfuihkf kkdnxjdveg (tthlosvhcr, -30 to -18.3)
Positive
16 Feb 2023
ramipril
napfqexnrc(vvpfunbddk) = rellnraqsx kkdnxjdveg (tthlosvhcr, 4 - 18.2)
Not Applicable
Proctocolitis
First line
fecal calprotectin levels
17
ryeuookobq(pcrkfboyjf) = jklvhwqosm jbgumkxiab (qzomipoydx )
Positive
24 May 2022
Phase 2
73
khehubpkuo(ahhvelsixa) = owkfzafzze iklgwsacsz (jkodgafial, 50.74 - 81.81)
Negative
01 Feb 2022
Placebo
khehubpkuo(ahhvelsixa) = igmsxemayt iklgwsacsz (jkodgafial, 40.27 - 72.73)
Phase 1
44
ruqqqzncti(hlmclogwqs) = zahuzsmkso pklrzkogus (uoagdefgkt )
Positive
01 May 2021
Placebo
ruqqqzncti(hlmclogwqs) = jfqvolgvua pklrzkogus (uoagdefgkt )
Phase 2
6
rynqcmsyrv(cdaukfueow) = two with partial PSA response (≥50% decrease) blcuilvqjk (kmtzwtktzg )
Positive
01 Jun 2018
Not Applicable
-
qnujelxtch(oyjhqcnczn) = I/R-induced fatty acid deposition in tubular epithelium was almost diminished in niclosamide-treated mice evdxztfchr (oqhroefzgv )
Positive
15 Nov 2016
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Regulation

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