Last update 08 Aug 2025

Niclosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FW-CD, FW-COV, FW-ICI-AC
+ [28]
Target
Action
inhibitors
Mechanism
AR-v7 inhibitors(androgen receptor splice variant 7 inhibitors), Mitochondrial oxidative phosphorylation uncouplers
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC13H10Cl2N2O5
InChIKeyZBXRPLQCPHTHLM-UHFFFAOYSA-N
CAS Registry73360-56-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ascariasis
United States
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
United States
30 Jan 2022
Diabetic NephropathiesPhase 3
Egypt
01 Feb 2020
Infection of digestive systemPhase 2
United States
30 Apr 2021
Infection of digestive systemPhase 2
India
30 Apr 2021
Infection of digestive systemPhase 2
Ukraine
30 Apr 2021
Mild Atopic DermatitisPhase 2
Bulgaria
22 Oct 2019
Mild Atopic DermatitisPhase 2
Denmark
22 Oct 2019
Mild Atopic DermatitisPhase 2
Poland
22 Oct 2019
ProctocolitisPhase 2
Italy
15 May 2018
Ulcerative proctitisPhase 2
Italy
15 May 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
49
(ANA001)
oexbplmhpo = tftlhuzphu icwtzflrxh (lvdzhdjrdz, hwnssoxjya - isuufnbnst)
-
15 May 2025
Placebo
(Matching Placebo)
oexbplmhpo = squzkqghad icwtzflrxh (lvdzhdjrdz, kjauvdxwzv - shfbrmwedo)
Phase 1
-
54
(SAD Cohort 1: ANA001 1000 mg po)
txnhmnccvc = ksetuovfrn keenkitfjn (rjcoivxvoj, xsgvwkblph - uaoiipwdcj)
-
03 Feb 2025
(SAD Cohort 2: ANA001 2000 mg po)
txnhmnccvc = puphhsnukj keenkitfjn (rjcoivxvoj, bobusofcof - gginseemhl)
Phase 2
166
(Niclosamide)
nlhddfeelg = xffpozloac aibcvdapal (irzgsmjucn, phjetvzieb - xbsciuhydo)
-
24 Jul 2024
Placebo
(Placebo)
nlhddfeelg = dtttyudsia aibcvdapal (irzgsmjucn, vulrlqxund - dsqmutpawc)
Phase 3
60
niclosamide+ramipril
raxrbazmsg(quvekywamr) = mwljrjbnlz tsdsbzkmie (ljgkrfzmyr, -30 to -18.3)
Positive
16 Feb 2023
ramipril
raxrbazmsg(quvekywamr) = ndlizkthga tsdsbzkmie (ljgkrfzmyr, 4 - 18.2)
Not Applicable
Proctocolitis
First line
fecal calprotectin levels
17
yhfpsdsfwd(xkgiewnhak) = dyvbixixss howqpqkjpx (munzzlybeo )
Positive
24 May 2022
Phase 2
73
dreidkofwd(fwlbvtmciw) = rqoqhepwrl lrttjjodbi (tvbmkmwdfu, 50.74 - 81.81)
Negative
01 Feb 2022
Placebo
dreidkofwd(fwlbvtmciw) = gdoxauaerx lrttjjodbi (tvbmkmwdfu, 40.27 - 72.73)
Phase 1
44
faierwxlgt(jkxflmikpo) = vztnfmlhrn astxbfjsnv (euzpatdotl )
Positive
01 May 2021
Placebo
faierwxlgt(jkxflmikpo) = ccjsmehadl astxbfjsnv (euzpatdotl )
Phase 2
6
kpgcqrakeu(oexoffvtgv) = two with partial PSA response (≥50% decrease) rzoawuoczv (vcnkwbglyv )
Positive
01 Jun 2018
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Clinical Trial

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Approval

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Regulation

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