Last update 21 Nov 2024

Niclosamide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FW-CD, FW-COV, FW-ICI-AC
+ [26]
Target
Mechanism
AR-v7 inhibitors(androgen receptor splice variant 7 inhibitors), Mitochondrial oxidative phosphorylation uncouplers
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC13H10Cl2N2O5
InChIKeyZBXRPLQCPHTHLM-UHFFFAOYSA-N
CAS Registry73360-56-2
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic NephropathiesNDA/BLA
EG
01 Feb 2020
COVID-19Phase 3
US
30 Jan 2022
Gastrointestinal infectionPreclinical
IN
30 Apr 2021
Gastrointestinal infectionPreclinical
UA
30 Apr 2021
Gastrointestinal infectionPreclinical
US
30 Apr 2021
ProctocolitisPreclinical
IT
15 May 2018
Ulcerative proctitisPreclinical
IT
15 May 2018
Crohn DiseasePreclinical--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
166
(Niclosamide)
(skgciwsjnu) = xktlmoetwu gzykkrsvsd (blixiybufl, uqiokiqqsx - ylxvgzsyhp)
-
24 Jul 2024
Placebo
(Placebo)
(skgciwsjnu) = lzbkspbupi gzykkrsvsd (blixiybufl, xiksesfdxd - ggzecweoun)
Phase 3
60
niclosamide+ramipril
(pgdxzuoeuw) = azgptpwlfa vmbgxhrbpv (qzokdpljgo, -30 to -18.3)
Positive
16 Feb 2023
ramipril
(pgdxzuoeuw) = ecsrhjeuew vmbgxhrbpv (qzokdpljgo, 4 - 18.2)
Phase 2
73
tjsxkcxrly(fxbfcgrqik) = wahzgqqywm zxppdnfdcp (skhrafwctl, 50.74 - 81.81)
Negative
01 Feb 2022
Placebo
tjsxkcxrly(fxbfcgrqik) = rrgheaudlw zxppdnfdcp (skhrafwctl, 40.27 - 72.73)
Phase 2
6
(iqjnxtcdle) = two with partial PSA response (≥50% decrease) payakbhpfy (vkuvhfqszx )
Positive
01 Jun 2018
Not Applicable
-
zhclbcunsr(ycnlndmxyz) = I/R-induced fatty acid deposition in tubular epithelium was almost diminished in niclosamide-treated mice ykkgjwxuti (gklatrdeiz )
Positive
15 Nov 2016
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Approval

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Regulation

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