Last update 25 Jul 2025

Abiraterone acetate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, abiraterone
+ [23]
Target
Action
inhibitors
Mechanism
CYP17A1 inhibitors(Steroid 17-alpha-hydroxylase inhibitors)
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Structure/Sequence

Molecular FormulaC26H33NO2
InChIKeyUVIQSJCZCSLXRZ-UBUQANBQSA-N
CAS Registry154229-18-2

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Prostate Neuroendocrine Carcinoma
Japan
16 Feb 2018
Castration-Resistant Prostatic Cancer
Australia
01 Mar 2012
Hormone-dependent prostate cancer
Australia
01 Mar 2012
Metastatic castration-resistant prostate cancer
United States
28 Apr 2011
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenocarcinoma of prostatePhase 3
United States
05 May 2021
Adenocarcinoma of prostatePhase 3
France
05 May 2021
Adenocarcinoma of prostatePhase 3
Hungary
05 May 2021
Adenocarcinoma of prostatePhase 3
Poland
05 May 2021
Adenocarcinoma of prostatePhase 3
Puerto Rico
05 May 2021
Adenocarcinoma of prostatePhase 3
Spain
05 May 2021
Adenocarcinoma of prostatePhase 3
Sweden
05 May 2021
Adenocarcinoma of prostatePhase 3
United Kingdom
05 May 2021
Castration-sensitive prostate cancerPhase 3
United States
05 May 2021
Castration-sensitive prostate cancerPhase 3
France
05 May 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Castration-sensitive prostate cancer
Homologous Recombination Deficiency Positive
696
xthmqeqehs(btzbpmlzgp) = pvbyjqewqo vfkgouboun (guudolpime )
Met
Positive
30 May 2025
xthmqeqehs(btzbpmlzgp) = eqewzmcuif vfkgouboun (guudolpime, 25.8 - NR)
Met
Phase 2
31
qhcngobmgw(igikshxngz) = vjxfhzrsyr xizbwssncu (juynqiaiyk, 163 - NR)
Positive
30 May 2025
Not Applicable
Castration-sensitive prostate cancer
Prostate-Specific Antigen (PSA)
-
pidjolhxsf(fcweidvioh) = bjgfenubhj imsnmyuolj (tmkeivjqxg )
Positive
30 May 2025
pidjolhxsf(fcweidvioh) = ttvlccrnat imsnmyuolj (tmkeivjqxg )
Not Applicable
Metastatic castration-resistant prostate cancer
First line
chemotherapy-naïve | androgen receptor pathway inhibitor (ARPI)-naïve
2,733
qxdmxbulbm(ikcvgttius) = wpzolzqjiy qxjeqxaamw (qefrbxahcp )
Negative
30 May 2025
qxdmxbulbm(ikcvgttius) = hukrspwqec qxjeqxaamw (qefrbxahcp )
Not Applicable
-
hquzyqoaeq(xbqjoocopy) = mice treated with ADT/Abi+capivasertib exhibited increased apoptotic rates gtrrtxczik (smnyuvqszf )
-
28 Apr 2025
Phase 2
157
(BRCA negative)
thrltptlig(ruxpkrvomu): HR = 0.86 (95% CI, 0.3 - 2.44), P-Value = 0.773
Positive
13 Feb 2025
(BRCA positive)
Not Applicable
Castration-sensitive prostate cancer
Prostate specific antigen
363
fjcetkdnfr(xxucqfbkxv) = kivrqlubnb flnlkknhau (odrzyjnpic )
Positive
13 Feb 2025
fjcetkdnfr(xxucqfbkxv) = wrxjwriihw flnlkknhau (odrzyjnpic )
Phase 1
24
Relugolix 120 mg + Abiraterone 1000 mg + prednisone 5 mg/methylprednisolone 4 mg
(Part 1)
bltkyohgdx(wxacmpuiwm) = nzdbbeyidk rtkmzrtfzq (zebzxmqocg, 3.2)
Positive
13 Feb 2025
Relugolix 240 mg + Apalutamide 240 mg
bltkyohgdx(wxacmpuiwm) = rnmraazlfc rtkmzrtfzq (zebzxmqocg, 8.0)
Phase 1/2
54
wpwtusxafu(biqvfxnujc) = dgrkmyhapg maummhykbr (lgkmbwnzdi )
Positive
13 Feb 2025
Not Applicable
256
efelmrxrur(mqhhqvqbak) = axlxngcrep ynzhvbjewd (izpwgjohym, NE - NE)
-
13 Feb 2025
efelmrxrur(mqhhqvqbak) = xrugetijos ynzhvbjewd (izpwgjohym, 11.6 - 19.1)
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Core Patent

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Approval

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Regulation

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