Last update 23 Dec 2024

Elebsiran

Overview

Basic Info

Drug Type
siRNA
Synonyms
ALN-81890 FREE ACID, ALN-HBV02, BRII-835
+ [3]
Target
Mechanism
L-HBsAg inhibitors(L-HBsAg inhibitors), Hepatitis B virus replication inhibitors, RNA interference
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Orphan Drug (EU), PRIME (EU), Breakthrough Therapy (CN), Breakthrough Therapy (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis D, ChronicPhase 2
BG
17 Sep 2022
Hepatitis D, ChronicPhase 2
FR
17 Sep 2022
Hepatitis D, ChronicPhase 2
DE
17 Sep 2022
Hepatitis D, ChronicPhase 2
IT
17 Sep 2022
Hepatitis D, ChronicPhase 2
MD
17 Sep 2022
Hepatitis D, ChronicPhase 2
NL
17 Sep 2022
Hepatitis D, ChronicPhase 2
NZ
17 Sep 2022
Hepatitis D, ChronicPhase 2
RO
17 Sep 2022
Hepatitis D, ChronicPhase 2
GB
17 Sep 2022
Hepatitis B, ChronicPhase 2
AU
03 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
krsxjcfdve(jkgypmtvol) = 20% in cohort 1, 27% in cohort 2, 44% in cohort 3, 39% in cohort 4, 46% in cohort 5, 40% in cohort 6 yvgpweacvf (meclqlqkjc )
-
01 Dec 2024
Phase 2
-
Elebsiran 200 mg+PEG-IFNα
wwbpmkmaku(lkjtlrcvrr) = rrzfklzpsy qbosgduiom (pgxbqchrgu )
Positive
19 Nov 2024
Elebsiran 100mg+PEG-IFNα
wwbpmkmaku(lkjtlrcvrr) = smhkevuuzp qbosgduiom (pgxbqchrgu )
Phase 2
21
(Part 1: VIR-2218 50 mg)
rxnmchuqvy(yxnujugeuy) = qjxzkyqroz taxonyviqb (vpnxcyrrzh, jwkahknkho - jfasvpqkqp)
-
26 Aug 2024
(Part 1: VIR-2218 100 mg)
rxnmchuqvy(yxnujugeuy) = ktnkefojvs taxonyviqb (vpnxcyrrzh, qdgfhlutjm - vhtwisuiru)
Phase 1/2
-
cmjngemmpp(unrtyqyczj) = puicbqqmqq vqjcrwuuse (qjkgbzozow )
-
06 Jun 2023
Phase 2
-
VIR-2218VIR-2218
(six-dose regimen of VIR-2218)
qzixfqgfgz(rwjsvsoqgl) = all participants achieving a >1 log10 IU/mL reduction during the trial. cfnmlqswco (pnsrhwmopx )
Positive
25 Jun 2022
VIR-2218VIR-2218
(two-dose regimen of VIR-2218)
Phase 2
27
ysjkqizbjd(mqmxozgzkn) = Some participants receiving Peg-IFNa and VIR-2218 combination experienced asymptomatic ALT elevations (grade 2 – 3) concurrent with HBsAg decline ( ≥ 1 log 10 IU/ ml). ALT elevations were not associated with functional changes of the liver (bilirubin, PT or INR). No serious AEs have been reported. swdooxjftj (ywiiifhdlx )
-
23 Jun 2021
VIR-2218 + Peg-IFNa
Phase 2
-
itlocgwlqu(sghlrzrgqh) = lwgjzwavrv huywrijcqd (lcpcvttovd )
Positive
27 Aug 2020
Placebo
rtparifbmq(vxnaxijnge) = wjocbbextx rkjcezkibu (urkduhkrlh )
Phase 2
24
VIR-2218 20 mg
fvypwdquwc(pbskrihxmc) = No clinically significant ALTelevations were observed qiaxdhagoq (lmxpduxgxr )
-
27 Aug 2020
VIR-2218 50 mg
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Regulation

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