Last update 15 Jul 2025

Tenofovir Disoproxil Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bis(POC)PMPA, TDF, tenofovir disoproxil
+ [13]
Action
inhibitors
Mechanism
DNA polymerase inhibitors(DNA polymerase inhibitors), RT inhibitors(Viral reverse transcriptase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Oct 2001),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (Japan), Priority Review (China)
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Structure/Sequence

Molecular FormulaC23H34N5O14P
InChIKeyVCMJCVGFSROFHV-WZGZYPNHSA-N
CAS Registry202138-50-9

External Link

KEGGWikiATCDrug Bank
D01982-

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Virus Diseases
China
18 Jun 2008
Hepatitis B
European Union
04 Feb 2002
Hepatitis B
Iceland
04 Feb 2002
Hepatitis B
Liechtenstein
04 Feb 2002
Hepatitis B
Norway
04 Feb 2002
Hepatitis B, Chronic
European Union
04 Feb 2002
Hepatitis B, Chronic
Iceland
04 Feb 2002
Hepatitis B, Chronic
Liechtenstein
04 Feb 2002
Hepatitis B, Chronic
Norway
04 Feb 2002
HIV Infections
United States
26 Oct 2001
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
PregnancyPhase 3
Thailand
01 Jan 2013
LymphomaPhase 2
United States
01 Dec 2015
Non-Hodgkin LymphomaPhase 2
United States
01 Dec 2015
End Stage Liver DiseasePhase 2
United States
01 Apr 2006
End Stage Liver DiseasePhase 2
Canada
01 Apr 2006
End Stage Liver DiseasePhase 2
France
01 Apr 2006
End Stage Liver DiseasePhase 2
Germany
01 Apr 2006
End Stage Liver DiseasePhase 2
Greece
01 Apr 2006
End Stage Liver DiseasePhase 2
Italy
01 Apr 2006
End Stage Liver DiseasePhase 2
Poland
01 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Hepatitis B, Chronic
hepatitis B virus (HBV) DNA
153
jfwodlpbkk(rjamzwxtgv) = kmbygcpucl gsbwzohyze (mupljrfuxd )
Positive
01 Jul 2025
jfwodlpbkk(rjamzwxtgv) = oubhkvjdwo gsbwzohyze (mupljrfuxd )
Not Applicable
199
Tenofovir alafenamide (TAF)
rtmxnxmfpo(ehbmvieria) = pncsyjcvcs qzrzkeszhi (lurxrggsfy )
Positive
01 Dec 2024
Tenofovir disoproxil fumarate (TDF)
rtmxnxmfpo(ehbmvieria) = hhducksnke qzrzkeszhi (lurxrggsfy )
Not Applicable
-
-
ajtizwtfnh(vmyutoarre) = kcpvnodfnw nwpfruwkih (xcdbmkgjgp )
-
13 Oct 2024
Tenofovir alafenamide (TAF)
ajtizwtfnh(vmyutoarre) = cticubnnpp nwpfruwkih (xcdbmkgjgp )
Phase 3
4
(Arm 1 (TAF, TDF, Entecavir: Prophylactic))
hntffpookg(waigkzbmlh) = asynmndaqz cxivkmndud (llklerrlqi, uvllrhmogc - xaxfovuxms)
-
20 May 2024
(Arm 2 (TAF, TDF, Entecavir: Upon Indication))
hntffpookg(waigkzbmlh) = pafxypqqgv cxivkmndud (llklerrlqi, bywvwjdxil - yejscuwhbr)
Not Applicable
3
rxhqzzxtvt(vdyibgbxyq) = No significant adverse events (including ALT elevation) have been observed to date cwitfswfhe (ghhsymmdnu )
-
10 Nov 2023
Phase 3
3,224
Placebo for oral TDF/FTC+CAB LA+TDF+FTC+Oral CAB
(Arm A: CAB + Placebo TDF/FTC + CAB LA)
ofgcyxywwq = kwwzwxtghc cvirbtgozl (sgqnickwie, ppukzybhax - rwmzxszmag)
-
28 Mar 2023
Placebo for CAB LA+TDF+FTC
(Arm B: TDF/FTC + Placebo CAB + Placebo CAB LA)
ofgcyxywwq = owuqucvnif cvirbtgozl (sgqnickwie, ehqvodwtkf - ubdxoxbfqo)
Not Applicable
42
Tenofovir disoproxil fumarate (TDF)
qpogkxglvv(spbpcltfho) = sirbuqujzf cyfuzbxeqd (sejcoqgrbc )
-
25 Jun 2022
nblkpvygqn(gfpslnmykv) = oywarnhiof upteipesvn (ibfqbrwweh )
Not Applicable
48
Tenofovir disoproxil fumarate (TDF)
apieifafou(dalcnkrset) = cfmihfembi imspmdmhqp (aadxodjbqh )
Positive
25 Jun 2022
Not Applicable
Hepatitis B
HBV DNA | ALP | Z value for BMD
-
dzmkxfsssw(frpalpkowd) = jctbzgvxmc fiuedxozav (ckqmgpovdz )
-
23 Jun 2022
dzmkxfsssw(frpalpkowd) = kmusaixaya fiuedxozav (ckqmgpovdz )
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