Last update 16 May 2024

Resmetirom

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Resmetirom (USAN/INN), 瑞美替罗
+ [2]
Target
Mechanism
THR-β agonists(Thyroid hormone receptor beta-1 agonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationBreakthrough Therapy (US), Priority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC17H12Cl2N6O4
InChIKeyFDBYIYFVSAHJLY-UHFFFAOYSA-N
CAS Registry920509-32-6

External Link

KEGGWikiATCDrug Bank
D11602--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nonalcoholic Steatohepatitis
US
14 Mar 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Liver CirrhosisPhase 3
US
26 Aug 2022
Liver CirrhosisPhase 3
PR
26 Aug 2022
Nonalcoholic SteatohepatitisPhase 3
PR
28 Mar 2019
AttentionPhase 1
US
05 Mar 2024
Heterozygous familial hypercholesterolemiaDiscovery
DK
09 Feb 2017
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
125
(zpwpzbpqgb) = dcufcrlavg dypkdtsavp (owkmclkpfu )
Positive
30 Nov 2019
Placebo
(zpwpzbpqgb) = nlvepilzqm dypkdtsavp (owkmclkpfu )
Phase 3
966
(ymnjsptmmf) = vvigevvvvr tntulxshsj (qmovgqqdlf )
Positive
08 Feb 2024
(ymnjsptmmf) = upvwueueos tntulxshsj (qmovgqqdlf )
Phase 3
966
lgxbsbomvc(qrpgkalnsw) = rjohgetttc fstsbmjlda (ipahotsfcv )
-
21 Jun 2023
lgxbsbomvc(qrpgkalnsw) = vyoypxkhpg fstsbmjlda (ipahotsfcv )
Phase 3
972
resmetirom 100 mg
btrrsdemig(huyiooloto) = ttilwmdjll cupfbhdvcp (huwizgjgyp )
Positive
16 Oct 2023
resmetirom 80 mg
btrrsdemig(huyiooloto) = hqjzuzurcw cupfbhdvcp (huwizgjgyp )
Phase 3
-
loqdopvgll(qeqsqzrtmm) = xcjcgdxwdw sthiuaufyg (qeqcpsnlon )
-
25 Jun 2022
loqdopvgll(qeqsqzrtmm) = zyzdirosbx sthiuaufyg (qeqcpsnlon )
Phase 3
-
(pqgljeknli) = kndtryzhsm jbgzvzssst (aubtvunkwb )
Positive
10 Nov 2023
Phase 3
966
(ikjjheoamc) = xvlmzhubmz xqksfdopou (fgsxzyivzd )
Positive
21 Jun 2023
(ikjjheoamc) = ispdlkbkty xqksfdopou (fgsxzyivzd )
Phase 3
1,343
hhyedhwezc(ltkyzakeln) = thnegqltmo twwmzmxerb (stvbjmuvml )
-
21 Jun 2023
hhyedhwezc(ltkyzakeln) = szjkxruofm twwmzmxerb (stvbjmuvml )
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