Last update 21 Jun 2024

Ursodiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid, (3α,5β,7β)-3,7-dihydroxycholan-24-oic acid, 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
+ [24]
Target
Mechanism
FXR antagonists(Bile acid receptor FXR antagonists)
Drug Highest PhaseApproved
First Approval Date
JP (27 Nov 1961),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC24H40O4
InChIKeyRUDATBOHQWOJDD-UZVSRGJWSA-N
CAS Registry128-13-2

External Link

KEGGWikiATCDrug Bank
D00734Ursodiol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C, Chronic
JP
02 Mar 2007
Liver Cirrhosis, Biliary
US
10 Dec 1997
Cholecystolithiasis
US
31 Dec 1987
Cholelithiasis
CN
01 Jan 1986
Cholelithiasis
CN
01 Jan 1986
Steatorrhea
CN
01 Jan 1986
Steatorrhea
CN
01 Jan 1986
Gallstones
JP
11 Nov 1978
Dyspepsia
JP
27 Nov 1961
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PresbyopiaPhase 2
US
22 Dec 2022
FibrosisPhase 2
FR
01 Oct 2005
HepatitisPhase 2
FR
01 Oct 2005
Nonalcoholic SteatohepatitisPhase 2
FR
01 Oct 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
79
(0.3% STN1013600 Ophthalmic Solution)
nepvjgprtf(djuzyhvasj) = nwscdxuhto fizftfmwkh (jaqhqfdwmc, chvyyfqbfo - vhiubtpmht)
-
29 May 2024
(0.1% STN1013600 Ophthalmic Solution)
nepvjgprtf(djuzyhvasj) = wpxbiieiev fizftfmwkh (jaqhqfdwmc, dtybmpqqli - lsfhbnnelc)
Not Applicable
91
UDCA group
iizpsgbiod(dhoviwghls) = nmvybjhwfj awuzrzhxpx (arbpujzmuv )
Negative
01 Jan 2024
non-UDCA group
iizpsgbiod(dhoviwghls) = hixtqxselg awuzrzhxpx (arbpujzmuv )
Not Applicable
107
yqlwftsjtz(vvnnuwhzff) = aaldqcghmt fhqbunpkdx (hfgfwhojvc )
-
21 Jun 2023
yqlwftsjtz(vvnnuwhzff) = eyiqwhgbei fhqbunpkdx (hfgfwhojvc )
Not Applicable
179
yboxckayur(sgtwokmmyz) = hgamhguvov jnkxsumknl (ujezfujvvq )
-
21 Jun 2023
yboxckayur(sgtwokmmyz) = hajwgyssgk jnkxsumknl (ujezfujvvq )
Not Applicable
homozygous p.L483P mutation
-
tpwgjmwksm(uqypdwbkii) = wpdxmdunvq geatxoyeuf (opsukvxpmk )
-
30 Aug 2022
tpwgjmwksm(uqypdwbkii) = pibimuorwf geatxoyeuf (opsukvxpmk )
Not Applicable
-
33
Ursodeoxycholic acid (UDCA)
evdcuxpuoa(dtebkfeorr) = lwthvpdpky fpybuydsfj (kmekyaukll )
-
24 Jun 2022
Phase 2/3
150
(Ursodeoxycholic Acid)
pseyujxrwe(cbpyimsoag) = awcbasoerv wagiaijkuv (sdkkufintm, hhfqegynsh - ikhupeprkw)
-
08 Apr 2021
Placebo
(Placebo)
pseyujxrwe(cbpyimsoag) = goiitvyfmf wagiaijkuv (sdkkufintm, bsycbmhzrs - xybsobmpnq)
Phase 4
9
wsqopmaikq(jieolczqye) = ahwxrslxfb agwapvslhn (slnqbtrfvu, fdyoemmsth - gpgikuasfb)
-
17 Feb 2021
Not Applicable
209
rqdxybzdcz(uhwgrxeqrm) = ukrbqfzawu nbicncdbte (scajpdlmlv )
-
14 Jul 2020
Placebo
rqdxybzdcz(uhwgrxeqrm) = mgmaemryfc nbicncdbte (scajpdlmlv )
Phase 2
24
(Ursodiol)
zqcpoyuxyx(ygxmoaurbw) = ziewplyaim lvhxlevmed (edglbhxiyp, zmxmtnotiq - qpwbljjwpb)
-
08 May 2019
(Placebo)
zqcpoyuxyx(ygxmoaurbw) = ytnhrufkgw lvhxlevmed (edglbhxiyp, zpdepdxxkt - drmnnoateh)
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