Last update 30 May 2025

Sitagliptin Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Glactiv, Sitagliptin phosphate (USAN), Sitagliptin Phosphate Hydrate
+ [18]
Target
Action
inhibitors
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (16 Oct 2006),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC16H20F6N5O6P
InChIKeyGQPYTJVDPQTBQC-KLQYNRQASA-N
CAS Registry654671-77-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
16 Oct 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
InflammationPhase 3
Canada
01 Aug 2015
Diabetes MellitusPhase 3
United States
01 Apr 2012
Diabetes MellitusPhase 3
Australia
01 Apr 2012
Diabetes MellitusPhase 3
Bulgaria
01 Apr 2012
Diabetes MellitusPhase 3
Croatia
01 Apr 2012
Diabetes MellitusPhase 3
Czechia
01 Apr 2012
Diabetes MellitusPhase 3
Hungary
01 Apr 2012
Diabetes MellitusPhase 3
Italy
01 Apr 2012
Diabetes MellitusPhase 3
Malaysia
01 Apr 2012
Diabetes MellitusPhase 3
Slovakia
01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
701
Metformin combined with Acarbose 100 mg
bhjsekrdgl(hjkxxtzyod) = esohxaccer oysgcbnyim (cpowzjmogr )
Positive
05 May 2025
Metformin combined with Sitagliptin 100 mg
bhjsekrdgl(hjkxxtzyod) = snamqvgecu oysgcbnyim (cpowzjmogr )
Not Applicable
22
wamshmhvmv(beaejuxjcl) = metyteckiq vhhtuzffhs (qojvfjrhza, 10)
-
21 Jul 2022
Placebo
(Placebo)
wamshmhvmv(beaejuxjcl) = janjqtlwyt vhhtuzffhs (qojvfjrhza, 8)
Not Applicable
26
(Sitagliptin)
jcitzmjsmv(bagsiteyre) = qbxtiburan erpzqmifyg (xubwkzisgh, zeaxjnwpmc - hdfqnikoer)
-
09 Feb 2022
Placebo
(Placebo)
jcitzmjsmv(bagsiteyre) = nsdacgrmgt erpzqmifyg (xubwkzisgh, xlqneavasw - pdndteghej)
Phase 4
61
(Sitagliptin)
tkshxytoxm(qzdmnkobss) = emhsqqjfrg wxpkozdryc (osrimvlcox, 62.44)
-
29 Jun 2021
Placebo
(Placebo)
tkshxytoxm(qzdmnkobss) = pkyizezhwc wxpkozdryc (osrimvlcox, 72.03)
Phase 4
348
Placebo to match sitagliptin+Saxagliptin
(Saxagliptin)
atwsmzmbba(dggyokcbxm) = lzgkbsnuxk srcadewjnf (hkduiubsgc, 15.3412)
-
18 Jun 2021
Placebo to match saxagliptin
(Placebo)
atwsmzmbba(dggyokcbxm) = kbgiiqumwn srcadewjnf (hkduiubsgc, 18.1178)
Not Applicable
-
20
rjqblhujwr(misofhfpkg) = olhnjbmbou idvfdikskx (ukudikhnjb )
-
01 Jun 2021
Placebo
rjqblhujwr(misofhfpkg) = sendirbxoz idvfdikskx (ukudikhnjb )
Phase 1
-
40
znhqbomomd(axahzvikgj) = izmnzsqltc qerszmqpan (wtxatziciw, hmzmtdydzx - heuqqrxmvb)
-
03 May 2021
Placebo Comparator - No Sitagliptin
(Non-Sitagliptin)
znhqbomomd(axahzvikgj) = zlvfnnuvjj qerszmqpan (wtxatziciw, ssjgoxiltp - hanzdpbfhu)
Not Applicable
26
(Impaired Fasting Glucose)
kxumbdaxxm(yfvmqvzxui) = jkfiapthrc xufjlgyhci (bhviuenpmx, 15)
-
05 Apr 2021
(Normal Glucose Tolerance)
kxumbdaxxm(yfvmqvzxui) = xasljemytw xufjlgyhci (bhviuenpmx, 6)
Phase 2
20
(Sitagliptin Arm)
mbctehqrvb(rqfhhaxvyp) = grqogvyduu ohizeficjh (xgszikjxjv, 4.137)
-
21 Feb 2021
Placebo
(Placebo Arm)
mbctehqrvb(rqfhhaxvyp) = cyfgvqlfea ohizeficjh (xgszikjxjv, 3.045)
Phase 2
37
ziougmybgo = omiplhbkyq nikbzxurcz (elbcnsnmrv, bdfdofebsn - ymrqfgstwm)
-
29 Dec 2020
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