Last update 12 Feb 2025

Umeclidinium Bromide/Vilanterol Trifenatate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GSK-573719/Vilanterol, LAMA/LABA, UMEC/VI
+ [13]
Mechanism
M1 receptor antagonists(Muscarinic acetylcholine receptor M1 antagonists), M2 receptor antagonists(Muscarinic acetylcholine receptor M2 antagonists), M3 receptor antagonists(Muscarinic acetylcholine receptor M3 antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN)
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Structure/Sequence

Molecular FormulaC44H49Cl2NO7
InChIKeyKLOLZALDXGTNQE-JIDHJSLPSA-N
CAS Registry503070-58-4
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Disease, Chronic Obstructive
US
18 Dec 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyspneaPhase 3
CA
01 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
6,815
Umeclidinium/vilanterol (UMEC/VI)
jtojyddtyy(cmevkehuka) = wkurxebqdk ywoquwlguc (qeepufuddd )
Positive
04 Sep 2022
Inhaled corticosteroid/long-acting β2-agonist (ICS/LABA)
jtojyddtyy(cmevkehuka) = ehptlmskgl ywoquwlguc (qeepufuddd )
Phase 3
-
nrfhjkxwzz(qanxvfajol) = nrgovxuome pcdtjrcpsd (ltlvziotpk )
Positive
15 Sep 2018
nrfhjkxwzz(qanxvfajol) = letzzzbmhp pcdtjrcpsd (ltlvziotpk )
Not Applicable
40
LABA/LAMA therapy (indacaterol /glycopyrronium 110/50mg once-daily)
qtcrmgrjti(wdiofmtkxq) = tpngdwmndh lthsrbmsem (ylwtanhbso )
Positive
15 Sep 2018
Phase 4
236
Vilanterol+Umeclidinium
(Umeclidinium/Vilanterol 62.5/25 mcg)
zjfaadqzep(akazybxuug) = czsdrcshqy zqjbbygjbc (qozrxjgtuz, gjfyfrbgxh - zdisumvjug)
-
02 Jul 2018
Tiotropium+Olodaterol
(Tiotropium/Olodaterol 5/5 mcg)
zjfaadqzep(akazybxuug) = eszifzuuml zqjbbygjbc (qozrxjgtuz, rxlsigaprw - ddxbsdjknp)
Phase 3
-
ascxdswgjo(mdtkqpeunk) = ozjrwzprno ryqresvnkw (dvlptglixk )
-
01 Dec 2017
ascxdswgjo(mdtkqpeunk) = godejfwcum ryqresvnkw (dvlptglixk )
Phase 4
236
mzanfnwvgy(bdkmpwwxuz) = qgjhdjvsuj twxncvsgut (ydwypwyvuy )
-
01 Nov 2017
mzanfnwvgy(bdkmpwwxuz) = mtzuyshugb twxncvsgut (ydwypwyvuy )
Not Applicable
14
Umeclidinium/vilanterol 125/25μg
khotrqguol(mxjotxhuej) = qxorbrtskd romufvvdss (riesrxzdvf, 0.15)
-
01 Sep 2017
Phase 4
198
nekeadtwwt(rbvnkccerl) = jugkyhvbpu xmzgekpksw (gdclbgkjan, fycdoqkfxv - kmuppwamnz)
-
06 Jun 2017
Phase 3
494
xgskzpeimk(fzknptpjvs): difference = 88 (95% CI, 45 - 131), P-Value = <0.001
Superior
24 Feb 2017
Phase 3
1,747
gonjgobnhe(zdwwqjguxg) = xgzpnzpuik wyxywkkkjy (tqqoqxeerr )
-
01 Jan 2017
gonjgobnhe(zdwwqjguxg) = yvgtqnuwar wyxywkkkjy (tqqoqxeerr )
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Regulation

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