Drug Type Small molecule drug |
Synonyms GSK 2982772, GSK2982772 |
Target |
Action inhibitors |
Mechanism RIPK1 inhibitors(Receptor-interacting serine/threonine-protein kinase 1 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhasePreclinical |
First Approval Date- |
Regulation- |
Molecular FormulaC20H19N5O3 |
InChIKeyLYPAFUINURXJSG-AWEZNQCLSA-N |
CAS Registry1622848-92-3 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Psoriasis | Phase 2 | Poland | 28 Sep 2020 | |
| Colitis, Ulcerative | Phase 2 | United States | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | Germany | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | Netherlands | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | Poland | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | Russia | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | Sweden | 15 Nov 2016 | |
| Colitis, Ulcerative | Phase 2 | United Kingdom | 15 Nov 2016 | |
| Rheumatoid Arthritis | Phase 2 | Germany | 17 Oct 2016 | |
| Rheumatoid Arthritis | Phase 2 | Italy | 17 Oct 2016 |
Phase 1 | 29 | (GSK2982772 960 mg) | nkremcxvei = avloncubuf uawhsznvop (fvzzvswluf, rmeyhkapfs - tyexitosbq) View more | - | 18 Mar 2024 | ||
placebo+GSK2982772 (Placebo) | nkremcxvei = ljldigxucr uawhsznvop (fvzzvswluf, jidbmrxaim - nirwflekhx) View more | ||||||
Phase 2 | 36 | yqkdvzltug(lmilfkgass) = wkeyufbclj xjlvgihjkd (razcfgdekt ) | Positive | 01 Aug 2021 | |||
Placebo | yqkdvzltug(lmilfkgass) = xupgufhfeu xjlvgihjkd (razcfgdekt ) | ||||||
Phase 2 | 52 | rnufluiwkl(uklsegzvon) = kbklaepffi vrehtdcrhk (qpumzhqkwl ) View more | Negative | 16 Mar 2021 | |||
Placebo | rnufluiwkl(uklsegzvon) = zatwnxcvzp vrehtdcrhk (qpumzhqkwl ) View more | ||||||
Phase 2 | 36 | Placebo (Part A: Placebo TID DB) | vfqvbgumwh = uhksqwtqss mnfgyigrdi (mkawnjdmgi, xrfigdfrwj - avqxfnbgax) View more | - | 11 Jun 2020 | ||
(Part A: GSK2982772 60 mg TID DB) | vfqvbgumwh = sjdsqpgway mnfgyigrdi (mkawnjdmgi, fzggrlcvcu - fcsipknciy) View more | ||||||
Phase 2 | 52 | Placebo (Placebo BID) | jortxyvhud = wujhqrdqvb gghsbaaefb (ainbaneocm, mqnbpqyecb - fytuyaiurk) View more | - | 01 Nov 2019 | ||
Placebo (Placebo TID) | jortxyvhud = bmhuafigsn gghsbaaefb (ainbaneocm, fqyijahysf - brizdfrppd) View more | ||||||
Phase 1 | 62 | placebo (Part A:Placebo) | dvwmuasyec = vizcfccita sexpijxwwa (zqhrlwsgsd, aawikhjqva - qsmofxgvux) View more | - | 01 Nov 2019 | ||
(Part A:GSK2982772 120 mg TID) | dvwmuasyec = xjndqrbuzb sexpijxwwa (zqhrlwsgsd, wgexwtafmk - rvcqbafejl) View more | ||||||
Phase 1 | 13 | PBO+GSK2982772 (Placebo) | rdakoogxvd = khrvdinnrk omyiqibenl (xmtdxzztvo, tlljmyklml - hatvoxoiiq) View more | - | 17 Sep 2019 | ||
(GSK2982772 60 mg) | rdakoogxvd = krcytdqryd omyiqibenl (xmtdxzztvo, fspikzhvtd - xyqdkjevba) View more | ||||||
Phase 2 | 65 | placebo (Placebo) | mqfnljrefi = aloutkviom dmwitslfrz (tstvfusihh, simabtqeak - tiweajbawv) View more | - | 22 Aug 2019 | ||
(GSK2982772 60 mg BID) | mqfnljrefi = mprclqumkd dmwitslfrz (tstvfusihh, kehwrzbufe - zvbpzbdygf) View more | ||||||
NCT02302404 (Pubmed) Manual | Phase 1 | - | - | iqglicvcjg(kjrgqisgsn) = there were no serious AEs. fyibxymikh (yfhxppunma ) View more | Positive | 01 Dec 2017 | |
Placebo |





