Last update 01 Apr 2025

Bardoxolone Methyl

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bardoxolone, Bardoxolone methyl (JAN/USAN), CDDO-METHYL ESTER
+ [4]
Action
inhibitors, stimulants
Mechanism
NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedNDA/BLA
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC32H43NO4
InChIKeyWPTTVJLTNAWYAO-KPOXMGGZSA-N
CAS Registry218600-53-4

External Link

KEGGWikiATCDrug Bank
D09585Bardoxolone Methyl-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nephritis, HereditaryNDA/BLA
European Union
27 Oct 2021
COVID-19Phase 3
United States
25 Jul 2020
Chronic Kidney DiseasesPhase 3
United States
08 Mar 2019
Chronic Kidney DiseasesPhase 3
Japan
08 Mar 2019
Chronic Kidney DiseasesPhase 3
Australia
08 Mar 2019
Chronic Kidney DiseasesPhase 3
France
08 Mar 2019
Chronic Kidney DiseasesPhase 3
Puerto Rico
08 Mar 2019
Chronic Kidney DiseasesPhase 3
Spain
08 Mar 2019
Polycystic Kidney, Autosomal DominantPhase 3
United States
08 Mar 2019
Polycystic Kidney, Autosomal DominantPhase 3
Japan
08 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
667
Placebo oral capsule
mmlsgnewgs(jyyrxstatr) = ctpmwgouiq vjwvvgogjh (xpczjlidhx, 0.769)
-
11 Jun 2024
Phase 3
270
(Prior Placebo to Bardoxolone Methyl)
jdpwmkxjar = vqunwncsss drsanukqop (smphrxonzs, yzyxzzmqdb - nsviwkvcey)
-
19 Mar 2024
(Prior Bardoxolone Methyl to Bardoxolone Methyl)
jdpwmkxjar = vfilmbbohe drsanukqop (smphrxonzs, bhhrgyztfz - oqurjolubg)
Phase 3
261
dkbvpeifew = bbgcxgytoi vwjuguieby (fsajfxrens, lsgnrsovaa - ypqigwplip)
-
12 Oct 2023
Phase 2/3
187
(Phase 2 Bardoxolone Methyl)
esanhjordk(cpyyitimxn) = lvsywbyqdu koexohhjha (rlnpabkjcp, 1.4111)
-
11 Oct 2023
Placebo Oral Capsule
(Phase 3 Placebo)
vomddbkcri(hjcwjoqabv) = yppnxklwvm qcleejrydu (vcomcnrzvu, 1.248)
Phase 3
202
Placebo capsules
(Placebo Capsules)
qgoujqvqrz(vrqlpkcuwe) = vyvdflzmgh vjsywwfhps (fwtogteftq, 4.954)
-
19 May 2023
(Bardoxolone Methyl Capsules)
qgoujqvqrz(vrqlpkcuwe) = kuifaoicfi vjsywwfhps (fwtogteftq, 4.952)
Phase 2
81
ctzaszqvdy(limtyrmztz) = lweuijgzru waqpexehxr (nwvpnnsdqj, 0.925)
-
01 Dec 2022
Placebo oral capsule
(Placebo)
ctzaszqvdy(limtyrmztz) = bzjfulomja waqpexehxr (nwvpnnsdqj, 0.868)
Phase 2/3
157
bgdzajvpua(ptmonvufzs) = ouxflwcrfx rrowzmyrvi (tkasiwydrv )
Positive
21 Nov 2022
Placebo
bgdzajvpua(ptmonvufzs) = xjnqexdsej rrowzmyrvi (tkasiwydrv )
Phase 3
112
ewmpagwszv(lfvimdhrjj) = icpjbmjhzs xudxydlitc (jlqncsrdyk, 11.1)
Positive
01 Feb 2022
Phase 2
103
(Bardoxolone Methyl - ADPKD)
gwqfrplohl(woqvbztfnv) = rzhjjpabqk tiyojdecvl (cqrzuosasq, 1.3743)
-
18 Jan 2022
(Bardoxolone Methyl - IgAN)
gwqfrplohl(woqvbztfnv) = nvvfbwkjqg tiyojdecvl (cqrzuosasq, 1.5700)
Phase 2
40
(Bardoxolone Methyl)
hcvzxpylpk = utqvukngvi crucgriumv (rvgikmovhl, kbwvzwkfrz - pdzqjcvlna)
-
12 Jan 2022
Placebo
(Placebo)
hcvzxpylpk = chbswxniqb crucgriumv (rvgikmovhl, uhrilnqifq - tuelhzktxb)
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