Delving into the Latest Updates on Bardoxolone Methyl with Synapse

This multi-center, randomized, double-blind, placebo-controlled, Phase 2 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with CKD due to multiple etiologies at risk of rapid disease progression. Approximately 70 patients will be enrolled and randomized 1:1 to either bardoxolone methyl or placebo. Patients with CKD secondary to varying etiologies will be enrolled from age 18-70 years with eGFR ≥ 20 to < 60 mL/min/1.73 m2, and other risk factors for rapid progression of kidney disease.
The maximum target dose will be determined by baseline proteinuria status. Patients with baseline urine albumin to creatinine ratio (UACR) ≤ 300 mg/g will be titrated to a maximum dose of 20 mg, and patients with baseline UACR > 300 mg/g will be titrated to a maximum dose of 30 mg. Qualified patients will be randomized 1:1 to receive either bardoxolone methyl or placebo once daily (preferably in the morning) throughout a 12-week dosing period.
Patients in the study will follow the same visit and assessment schedule. Patients will be assessed during treatment at Day 1, Weeks 1, 2, 4, 6, 8, and 12 and by telephone contact on Days 3, 10, 21, 31, 35, and 45. Date of last dose and the end-of-treatment assessments mark the end of the treatment period. Patients will not receive study drug during a 5-week off-treatment period between Weeks 12 and 17. The off-treatment (OT) period includes 5 visits requiring various assessments to characterize eGFR from the time of study drug discontinuation through Day 35 off-treatment.

Start Date09 Feb 2021

Sponsor / Collaborator

Biogen, Inc.

NCT04494646

/ CompletedPhase 2IIT

BARCONA: A Phase II, Randomized, Double-blind, Placebo-controlled, Multi-center Study of the Effects of Bardoxolone Methyl in Participants With SARS-Corona Virus-2 (COVID-19)

This multi-center, double-blind, placebo-controlled, randomized Phase 2 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in patients hospitalized with confirmed COVID-19. The trial will include approximately 40 patients and is designed to provide an early interim analysis of safety. Patients will be randomized using permuted block randomization in a 1:1 fashion to either once-daily administration of bardoxolone methyl (20 mg) or matching placebo and treatment will be administered for the duration of hospitalization (until recovery), with a maximum treatment duration of 29 days.

Start Date08 Sep 2020

Sponsor / Collaborator

NYU Langone Health

[+1]

100 Clinical Results associated with Bardoxolone Methyl

Login to view more data

100 Translational Medicine associated with Bardoxolone Methyl

Login to view more data

100 Patents (Medical) associated with Bardoxolone Methyl

Login to view more data

597

Literatures (Medical) associated with Bardoxolone Methyl

01 Jul 2026·FREE RADICAL BIOLOGY AND MEDICINE

CDDO-Me alleviates doxorubicin/lapatinib-induced cardiotoxicity by activating the NRF2/GPX4 axis to inhibit oxidative stress and ferroptosis

Article

Author: Huang, Zengyi ; Yin, Yangguang ; Hu, Qinghua ; Yin, Manjialan ; Chen, Xiaojiao ; Chen, Bo ; Zhou, Weiying ; Suo, Lifei ; Huang, Guangxu

The combination of doxorubicin (DOX) and lapatinib (LAP) enhances the antitumor efficacy of breast cancer. However, previous studies indicated that this combination exacerbated cardiotoxicity through ferroptosis, characterized by mitochondrial dysfunction, lipid peroxidation, and glutathione depletion. Current cardiotoxicity treatments are inadequate, necessitating alternative solutions. Here, this study investigates whether bardoxolone methyl (CDDO-Me), a synthetic triterpenoid NRF2 activator, alleviates DOX/LAP-induced cardiac injury by modulating the NRF2/GPX4 pathway. Our data showed that CDDO-Me significantly reduced DOX/LAP-induced cardiotoxicity in mice, improving cardiac function, reducing myocardial fibrosis, and attenuating hypertrophy. Mechanistically, CDDO-Me directly bound and stabilized GPX4, inhibiting its ubiquitination and degradation through the ubiquitin-proteasome (UPS) pathway. This restored glutathione homeostasis, suppressed lipid peroxidation, and mitigated mitochondrial dysfunction and iron overload. Furthermore, CDDO-Me did not compromise the antitumor efficacy of DOX/LAP in breast cancer cells. CDDO-Me protects against DOX/LAP-induced cardiotoxicity by stabilizing GPX4 and inhibiting ferroptosis, offering a promising therapeutic strategy that preserves cardiac function without interfering with chemotherapy.

01 Jun 2026·AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Divergent mitochondrial stressors elicit specific retrograde signaling pathways in muscle myotubes

Article

Author: Sztolsztener, Klaudia ; Hood, David A. ; Mahendran, Thulasi

This study investigates how different mitochondrial stressors activate distinct cellular signaling pathways in skeletal muscle cells. It examines how cells maintain a balance between protein homeostasis and oxidative stress when mitochondrial proteases, chaperones, and protein import are inhibited, and during acute contractile activity. The findings from this study provide key insights into mitochondrial protein homeostasis, stress signaling, and muscle adaptation mechanisms highlighting that downstream adaptive responses depend on the type of stressors.

01 Jun 2026·Journal of Advanced Research

HDAC3 represses Nrf2-GDF11 signaling to drive chondrocyte adipogenesis in temporomandibular joint osteoarthritis

Article

Author: Yu, Shibin ; Li, Fuyin ; Shi, Yuqian ; Wu, Fan ; Zhan, Ying ; Xu, Zhihua ; Wang, Helin ; Fan, Peinan ; He, Feng ; Li, Qinghua ; Zhang, Hongyun ; He, Fa ; Zhang, Mian ; Liu, Qian

INTRODUCTION:

Aberrant biomechanical force-induced chondrocyte adipogenesis is involved in the development of temporomandibular joint osteoarthritis (TMJ OA). Growth differentiation factor 11 (GDF11) has been implicated in this process. However, whether mechanosensitive histone deacetylase 3 (HDAC3) regulates GDF11 signaling in the context of TMJ OA remains to be elucidated.

OBJECTIVE:

To elucidate the HDAC3-mediated regulation of GDF11 during chondrocyte adipogenesis in TMJ OA.

METHODS:

A unilateral anterior crossbite (UAC) rat model and cyclic tensile strain (CTS)-stimulated ATDC5 cells were established to mimic aberrant biomechanical force. Cartilage degeneration was assessed via Safranin O staining and qRT-PCR. Chondrocyte adipogenesis was evaluated using Oil Red O staining, transmission electron microscopy (TEM), and Adiponectin immunohistochemistry (IHC). The expression of HDAC3, nuclear factor erythroid 2-related factor 2 (Nrf2), and GDF11 was quantified by IHC, qRT-PCR, and western blotting. The binding of Nrf2 to GDF11 was evaluated by dual-luciferase reporter assays. The therapeutic interventions included intra-articular injections of the HDAC3 inhibitor RGFP966 (10 mg/kg) and the Nrf2 agonist Bardoxolone (10 mg/kg).

RESULTS:

The articular cartilage was significantly thinner, the modified Osteoarthritis Research Society International (OARSI) scores were increased, the expression of cartilage matrix markers (collagen II and aggrecan) was reduced, and the expression of chondrocyte hypertrophic markers (collagen X, matrix metalloprotease-13, and alkaline phosphatase) was increased in the UAC-induced OA model group compared with the sham control group. Excessive biomechanical force accelerated chondrocyte adipogenesis, as indicated by increased lipid droplet accumulation and Adiponectin upregulation. Concurrently, HDAC3 was upregulated, which suppressed Nrf2 and downregulated GDF11. Dual-luciferase reporter assays confirmed the direct binding of Nrf2 to the GDF11 promoter in chondrocytes. Treatment with the HDAC3 inhibitor RGFP966 or the Nrf2 agonist Bardoxolone restored GDF11 expression, significantly attenuating adipogenesis and alleviating cartilage degeneration.

CONCLUSIONS:

Our findings indicate that aberrant biomechanical force induces HDAC3 upregulation, which suppresses Nrf2-mediated transactivation of GDF11, thereby promoting chondrocyte adipogenesis and exacerbating TMJ OA progression.

41

News (Medical) associated with Bardoxolone Methyl

08 Dec 2023

·synapse.patsnap.com

What are Nrf2 inhibitors and how do you quickly get the latest development progress?

Nrf2, or nuclear factor erythroid 2-related factor 2, is a transcription factor that plays a crucial role in the human body's defense against oxidative stress and inflammation. It regulates the expression of various antioxidant and detoxification genes, promoting cellular protection and maintaining redox homeostasis. Nrf2 activation is essential for combating harmful free radicals and reactive oxygen species, which can lead to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. Understanding and harnessing the potential of Nrf2 signaling pathways have become a significant focus in pharmaceutical research, aiming to develop novel therapeutic interventions for oxidative stress-related diseases. Due to the biological characteristics of tumors, multidrug resistance (MDR) is a major cause of chemotherapy failure. Studies have shown that high expression of Nrf2 is found in different types of cancer cells (bladder cancer, lung cancer, pancreatic cancer, liver cancer, and head and neck cancer). Nrf2 can activate the transcription of more than 500 genes in the human genome, most of which have cell protective functions, enhancing the detoxification and excretion of harmful substances and toxic metals, thereby leading to tumor resistance to chemotherapy drugs. Therefore, the development of Nrf2 inhibitors is considered an important strategy to overcome chemotherapy drug resistance. The use of Nrf2 inhibitors as sensitizers in combination with anticancer drugs will reverse tumor resistance and significantly improve the efficacy of chemotherapy drugs. The analysis of the target Nrf2 in the pharmaceutical industry reveals a competitive landscape with companies like Biogen, Inc., Reata Pharmaceuticals, Inc., and Teva Pharmaceutical Industries Ltd. leading the way in R&D progress. Multiple drugs targeting Nrf2 have been approved for indications such as Multiple Sclerosis and Friedreich Ataxia. Small molecule drugs are progressing rapidly, with biosimilars indicating intense competition. The United States is at the forefront of development, followed by the European Union, China, and other countries. The future development of target Nrf2 holds promise for the treatment of various indications and requires continued research and investment in innovative drug development. How do they work?Nrf2 inhibitors are a class of compounds or drugs that specifically target and inhibit the activity of the nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is a transcription factor that plays a crucial role in regulating the expression of genes involved in antioxidant response and cellular defense against oxidative stress. From a biomedical perspective, Nrf2 inhibitors are of interest because they have the potential to modulate the Nrf2 pathway and alter the cellular response to oxidative stress. By inhibiting Nrf2, these compounds can prevent the activation of antioxidant genes and disrupt the cellular defense mechanisms against oxidative damage. Nrf2 inhibitors have been studied in various biomedical contexts, including cancer research. In some cancer cells, Nrf2 is overexpressed, leading to increased antioxidant capacity and resistance to chemotherapy or radiation therapy. By inhibiting Nrf2, researchers aim to sensitize cancer cells to treatment and enhance the effectiveness of anticancer therapies. Moreover, Nrf2 inhibitors have also been investigated as potential therapeutic agents for other conditions associated with oxidative stress, such as neurodegenerative diseases, cardiovascular diseases, and inflammatory disorders. By modulating the Nrf2 pathway, these inhibitors may offer a way to restore redox balance and mitigate the detrimental effects of oxidative stress in these conditions. It is important to note that the development and use of Nrf2 inhibitors require careful consideration of their potential side effects and impact on normal cellular functions. While inhibiting Nrf2 may be beneficial in certain disease contexts, it may also disrupt the physiological antioxidant defense mechanisms and have unintended consequences. Therefore, further research and clinical trials are necessary to fully understand the therapeutic potential and safety profile of Nrf2 inhibitors. List of Nrf2 InhibitorsThe currently marketed Nrf2 inhibitors include: OmaveloxoloneMonomethyl fumarateDiroximel fumarateDimethyl fumarateBardoxolone MethylOltipraz10-Nitrooleic acidALZ-001ALZ-002APPAFor more information, please click on the image below. What are Nrf2 inhibitors used for?Nrf2 inhibitors have been studied in various biomedical contexts, including cancer research. For more information, please click on the image below to log in and search. How to obtain the latest development progress of Nrf2 inhibitors?In the Synapse database, you can keep abreast of the latest research and development advances of Nrf2 inhibitors anywhere and anytime, daily or weekly, through the "Set Alert" function. Click on the image below to embark on a brand new journey of drug discovery!

10 May 2023

·www.fiercebiotech.com

Reata, Kyowa Kirin's bardoxolone faces the music after ph. 3 flop, ending 13-year saga

Kyowa Kiryin and Reata have worked together on bardoxolone for more than 13 years. Reata and Kyowa Kirin are burying bardoxolone methyl after new phase 3 data laid bare the dwindling—if not non-existent—potential of the kidney disease treatment. The two companies said that while the treatment hit the primary and secondary endpoints in a phase 3 trial testing bardoxolone in patients with diabetic kidney disease, there was no difference in the time to end-stage renal disease between treated patients and placebo. That was the nail in the coffin, with Kyowa and Reata saying Wednesday that they’ll end development of bardoxolone as a treatment for chronic kidney disease. Investors punished Reata for the disappointing conclusion, with shares down roughly 23% an hour after the market opened, from $105.37 down to $81. Thus ends an incredibly tumultuous saga for bardoxolone that’s extended some 13 years and spanned three different partnerships. Reata first handed over commercialization rights to certain markets to both Kyowa Kirin and Abbott (now AbbVie) back in 2009 and 2010, respectively, when bardoxolone was in phase 2 development for patients with diabetes who had chronic kidney disease. AbbVie double dipped a year later, offering up another $400 million to jointly develop and commercialize other Reata projects aimed at kidney and autoimmune diseases. But the wheels slowly, but surely, began to come off, beginning in 2012 when a phase 3 trial was halted after treated patients were experiencing higher rates of heart-related side effects, including hospitalizations and death. The company swiftly pivoted to aiming the treatment at patients with pulmonary arterial hypertension. Reata couldn’t just step away from the kidney ambitions, however, launching additional studies including one testing bardoxolone in patients with chronic kidney disease caused by Alport syndrome. AbbVie had enough, backing out in 2019 and recouping $330 million out of the original $850 million it handed over across the two deals. FDA advisors told Reata to go back to the drawing board two years later when they unanimously voted against the risk-benefit profile of bardoxolone kidney disease treatment in patients with Alport syndrome. The FDA formally rejected the med last year. Kyowa Kirin has dutifully held on throughout, launching a phase 3 study five years ago testing bardoxolone in diabetic patients with chronic kidney disease. But after the latest readout, the Japanese pharma said it no longer sees a viable regulatory route. The axed development plan has forced Reata to address a $350 million investment from Blackstone in 2020 to help develop bardoxolone, the majority of which was to be paid from royalties on the treatment. Reata says Blackstone will now receive single-digit royalties on Skyclarys (omaveloxolone), which was approved in March as a treatment for Friedreich’s ataxia and is one of two assets remaining in the company's pipeline. Reata's attention is now on the commercialization effort for Skyclarys. The company says it has received approximately 500 patient start forms since approval but doesn’t expect to be in specialty pharmacies until mid-August while the FDA reviews an NDA supplement submitted by Reata asking for an increase in drug substance specification. The company says approval of the supplement is required before the drug can be sent to pharmacies. Reata is also working on RTA 901 treatment for diabetic peripheral neuropathic pain, completing a phase 1 single ascending and multiple ascending dose study. The company planned to launch a phase 2 study in the second half of 2022 but it’s unclear if that’s happened. A phase 2 clinical trial record was not found on clinicaltrials.gov.

Phase 3Phase 2Drug ApprovalNDAPhase 1

10 May 2023

·endpts.com

Reata culls bardoxolone, ending decade of R&D on troubled kidney disease drug

Reata’s long and winding road with bardoxolone appears to be over. The Plano, TX-based biotech and partner Kyowa Kirin said Wednesday morning that they are scrapping development of the asset in chronic kidney disease programs, which include CKD caused by Alport syndrome, people with diabetic CKD and a rare, hereditary form of the disease. With that, Reata expects to save more than $100 million previously set aside for the drug, a move that will push runway to the end of 2026, the company said in a presentation. Reata also disclosed a non-dilutive $275 million debt facility as part of its first-quarter update .

100 Deals associated with Bardoxolone Methyl

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
D09585	Bardoxolone Methyl	-	DB05983

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Nephritis, Hereditary	NDA/BLA	European Union	Reata Pharmaceuticals, Inc.	27 Oct 2021
Kidney Failure, Chronic	Phase 3	United States	Biogen, Inc.	08 Mar 2019
Kidney Failure, Chronic	Phase 3	Japan	Biogen, Inc.	08 Mar 2019
Kidney Failure, Chronic	Phase 3	Australia	Biogen, Inc.	08 Mar 2019
Kidney Failure, Chronic	Phase 3	France	Biogen, Inc.	08 Mar 2019
Kidney Failure, Chronic	Phase 3	Spain	Biogen, Inc.	08 Mar 2019
Polycystic Kidney, Autosomal Dominant	Phase 3	United States	Biogen, Inc.	08 Mar 2019
Polycystic Kidney, Autosomal Dominant	Phase 3	Japan	Biogen, Inc.	08 Mar 2019
Polycystic Kidney, Autosomal Dominant	Phase 3	Australia	Biogen, Inc.	08 Mar 2019
Polycystic Kidney, Autosomal Dominant	Phase 3	France	Biogen, Inc.	08 Mar 2019

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03918447 (FALCON, CTgov)	Phase 3	Polycystic Kidney, Autosomal Dominant	667	Placebo oral capsule	hqrujwvoap(jntqvqjavr) = zbbczhcale pxxwxideme (pwvpnjqqmu, 0.769) View more	-	11 Jun 2024
NCT03749447 (EAGLE, CTgov)	Phase 3	Polycystic Kidney, Autosomal Dominant \| Kidney Failure, Chronic \| Nephritis, Hereditary ... View more	270	Placebo+Bardoxolone Methyl (Prior Placebo to Bardoxolone Methyl)	jjidjtohax = dlditnyayi mmkfjepuln (klcqxxtqou, tuijbwmfvo - chovultfet) View more	-	19 Mar 2024
				Bardoxolone Methyl (Prior Bardoxolone Methyl to Bardoxolone Methyl)	jjidjtohax = kakqpmrihs mmkfjepuln (klcqxxtqou, scqtwptsmy - airavhmrhn) View more
NCT03068130 (RANGER, CTgov)	Phase 3	Hypertension, Pulmonary	261	Bardoxolone Methyl	jusekafhpw = hjnumehdol ixycnafaoa (yzkmxrnqfu, uwlpqhmhem - lhfryiwtok) View more	-	12 Oct 2023
NCT03019185 (CARDINAL, CTgov)	Phase 2/3	Nephritis, Hereditary	187	Bardoxolone Methyl (Phase 2 Bardoxolone Methyl)	uvygofgldk(cwlltcklqg) = tpjswextzs bkblxqorhx (lbuwiqookv, 1.4111) View more	-	11 Oct 2023
				Placebo Oral Capsule (Phase 3 Placebo)	bknrzzcfng(tdbskkpbtw) = bztbcrvnfi ezrbwgadxj (yffbomcyde, 1.248) View more
NCT02657356 (CTgov)	Phase 3	Connective Tissue Diseases \| Pulmonary arterial hypertension associated with connective tissue disease	202	Placebo capsules (Placebo Capsules)	zohcynzeyt(lhsjdjdrvv) = cjatnryefm cgadtixich (codpqqzmrm, 4.954) View more	-	19 May 2023
				Bardoxolone methyl capsules (Bardoxolone Methyl Capsules)	zohcynzeyt(lhsjdjdrvv) = vyknnxqmba cgadtixich (codpqqzmrm, 4.952) View more
NCT04702997 (MERLIN, CTgov)	Phase 2	Chronic Kidney Diseases	81	Bardoxolone methyl oral capsule (Bardoxolone Methyl)	xoajufwgio(qhsvqzzpyi) = cwpesateiw wgztlappfo (bjsotkqwpi, 0.925) View more	-	01 Dec 2022
				Placebo oral capsule (Placebo)	xoajufwgio(qhsvqzzpyi) = eugjgtyxer wgztlappfo (bjsotkqwpi, 0.868) View more
NCT03019185 (CARDINAL, Pubmed) Manual	Phase 2/3	Nephritis, Hereditary	157	Bardoxolone Methyl	osvieuzjlu(pwwsuyyzze) = lygfcskhal xkuvoupxnh (oqcfakthab ) View more	Positive	21 Nov 2022
				Placebo	osvieuzjlu(pwwsuyyzze) = njewbgbvqk xkuvoupxnh (oqcfakthab ) View more
NCT03749447 (EAGLE, ISN WCN2022)	Phase 3	Nephritis, Hereditary	112	Bardoxolone methyl 5 mg	igcasdqagm(crsdsdijhk) = dwplfjobbz dyhovklqat (shykptqrns, 11.1)	Positive	01 Feb 2022
NCT03366337 (PHOENIX, CTgov)	Phase 2	Polycystic Kidney, Autosomal Dominant \| Type 1 diabetes mellitus with established diabetic nephropathy \| Glomerulosclerosis, Focal Segmental ... View more	103	Bardoxolone methyl capsules (Bardoxolone Methyl - ADPKD)	hvwijwjsvz(rehjougkuz) = wfcothbswu shpzscmfgn (bbvieudmjs, 1.3743) View more	-	18 Jan 2022
				Bardoxolone methyl capsules (Bardoxolone Methyl - IgAN)	hvwijwjsvz(rehjougkuz) = cyayqelyqo shpzscmfgn (bbvieudmjs, 1.5700) View more
NCT04494646 (CTgov)	Phase 2	COVID-19	40	Bardoxolone Methyl (Bardoxolone Methyl)	umvqrguflq = qljpxqyjfu wpibqmahvr (lnlazaqtaf, lbtyzgbyvp - htqbgpgyon) View more	-	12 Jan 2022
				Placebo (Placebo)	umvqrguflq = gutolqexey wpibqmahvr (lnlazaqtaf, nvchbkvrcn - yyqeamfexn) View more