Delving into the Latest Updates on Quinine Sulfate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Qualaquin, Quinine capsules, Quinine hydrogen sulfate

+ [9]

Target-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication

Malaria, FalciparumMalaria

Inactive Indication

Renal Insufficiency

Originator Organization

Sun Pharmaceutical Industries Ltd.

Active Organization

Sun Pharmaceutical Industries, Inc.Grand Pharmaceutical Group

Inactive Organization

Mutual Pharmaceutical Co., Inc.

Drug Highest PhaseApproved

First Approval Date

US (12 Aug 2005),

Malaria, Falciparum

RegulationOrphan Drug (US)

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Structure

Molecular FormulaC20H24N2O2

InChIKeyLOUPRKONTZGTKE-WZBLMQSHSA-N

CAS Registry130-95-0

View All Structures (2)

This is a multicenter, randomized, open-label, controlled trial to evaluate the effectiveness and safety of Quinine Sulfate as an add-on therapy in hospitalized adults with COVID-19.
The study is a multi-center trial that will be conducted in up to approximately 2 sites nationally. New sites may be added as needed after appropriate assessment. Interim monitoring will be conducted to evaluate the arms and for safety and effectiveness. Any changes would be accompanied by an updated sample size.
Subjects will be assessed while hospitalized. All subjects will undergo a series of laboratory tests (CBC, SGOT, SGPT, Ureum, Creatinine, EKG, and PCR), clinical examination (clinical assessment, vital signs, accompanying drugs, and other medical conditions) and safety assessment (serious adverse events/ SAE)
Randomization will be performed 1:1 for each arm. Arm 1 = Standard of Care (SoC) alone, arm 2 = SoC + Quinine Sulfate

Start Date26 Apr 2021

Sponsor / Collaborator

Universitas Padjadjaran

[+1]

NCT02598713 / RecruitingPhase 1IIT

Validation of Markers for Aspiration for Endotracheal Tube Cuff Leak

The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube [ETT] cuff leakage) in mechanically ventilated, critically ill patients.

Start Date01 Dec 2015

Sponsor / Collaborator

The General Hospital Corp.

NCT02630472 / TerminatedPhase 1/2IIT

Efficacy and Safety of Adjuvant Topical Irrigation in the Treatment of Acute Exacerbation of Chronic Rhinosinusitis Following Functional Endoscopic Sinus Surgery (FESS)

The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery. Subjects who have previously had functional endoscopic sinus surgery with acute exacerbation of chronic rhinosinusitis will be randomized to either a quinine-saline or saline-placebo arm. The investigators will measure baseline and follow-up clinical and quality-of-life outcomes for both arms, and then compare the groups at the end of the study period. The investigators' hypothesis is that the participants in the quinine sulfate arm will perform better on all measures as compared to the control arm.

Start Date01 Oct 2015

Sponsor / Collaborator

University of Pennsylvania

100 Clinical Results associated with Quinine Sulfate

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100 Translational Medicine associated with Quinine Sulfate

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100 Patents (Medical) associated with Quinine Sulfate

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504

Literatures (Medical) associated with Quinine Sulfate

01 Nov 2024·Poultry Science

Impact of dietary fat types on expression levels of dopamine and serotonin transporters in the ileum of broiler chickens

Article

Author: Han, Jian ; Fasina, Yewande O ; Apalowo, Oluwabunmi O. ; Iwuozo, Odinaka C ; Iwuozo, Odinaka C. ; Ogundare, Tunde E ; Omaliko, Paul C. ; Enenya, Ikenna G. ; Omaliko, Paul C ; Ferket, Peter R ; Ogundare, Tunde E. ; Fasina, Yewande O. ; Enenya, Ikenna G ; Apalowo, Oluwabunmi O ; Ferket, Peter R.

Various types of dietary fats undergo distinct fermentation processes by gut microbes, potentially leading to the production of neurotransmitters that can influence the gut. Serotonin and dopamine are recognized neurotransmitters with positive effects on gut function. A broiler chicken trial was conducted to evaluate the influence of dietary fat types on protein expression of 2 neurotransmitter transporters, dopamine (DAT) and serotonin (5-HTT). A total of 560 day-old (Ross 708) male broiler chicks were randomly assigned to 7 dietary treatments. The experimental treatments included a basal diet of corn-soybean meal (SBM), supplemented with 3% of various fats: poultry fat (CON), olive oil (OLIV), fish oil (FISH), canola oil (CANO), lard (LARD), coconut oil (COCO), or flaxseed oil (FLAX). Bodyweight (BW) and feed conversion ratio (FCR) were recorded. Ileal tissues were aseptically collected to determine the expression levels of DAT and 5-HTT through western blot analysis. In addition, plasma samples were analyzed for reactive oxygen metabolites (d-ROM) tests on d 55. Results showed that dietary fat type inclusion did not have any detrimental effect on growth performance parameters. The expression levels of DAT were higher (P < 0.05) in FLAX treatments compared to CON treatments on d 20 and d 55, respectively. Similarly, with 5-HTT levels, FLAX, CANO, and LARD treatments were higher (P < 0.05) than CON treatments on d 20 and d 55. However, higher levels of oxidative stress (d-ROM values) were recorded in COCO (32.75 Carr U), CANO (29 Carr U), and CON treatments (25.5 Carr U) compared to FLAX (18.5 Carr U; P < 0.05) treatment. These findings suggest that incorporating dietary flaxseed oil at a 3% level in the diet has significant potential to elevate the expression levels of intestinal DAT and 5-HTT without inducing oxidative stress.

01 Oct 2024·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Propeller shaped triarylamine acid: An ultra-sensitive fluorescence probe for distinguishing propanol isomers and water sensing in organic solvents

Article

Author: Karthikeyan, Subramanian ; Moon, Dohyun ; Al-Sehemi, Abdullah G ; Pannipara, Mehboobali ; Anthony, Savarimuthu Philip ; Ravi, Sasikala

The photophysical properties of conformationally flexible (TPA-C) and partially rigidified (Cz-C) triarylamine acids were explored in solid as well as solution state and correlated with the structure. TPA-C and Cz-C exhibited moderate solid-state fluorescence (Φ_f = 6.2 % (TPA-C) and 5.6 % (Cz-C)) and self-reversible mechanofluorochromism. TPA-C produced fluorescent polymorphs (TPA-C-1 and TPA-C-2) with tunable fluorescence. TPA-C-1 showed unusual carboxylic acid intermolecular interactions whereas TPA-C-2 and Cz-C showed usual carboxylic acid dimer. TPA-C exhibited strong solvent polarity dependent tunable fluorescence (Φ_f = 0.01 to 0.11 compared to quinine sulphate standard) but Cz-C was non-emissive in the solution state. The dual emissive TPA-C showed highly sensitive fluorescence changes in organic solvents (CH₃CN, THF, DMF, EtOH) when trace amount of water was added. In CH₃CN, TPA-C showed weak fluorescence at 474 nm and addition of water (1 %) exhibited significant blue shift (λ_max = 416 nm). The fluorescence intensity was gradually decreased with blue shifting in DMF, THF and EtOH with water addition. Importantly, TPA-C showed drastically different fluorescence in n-propanol (n-PA) and iso-propanol (IPA). TPA-C in n-PA showed fluorescence at 408 nm that was clearly red shifted to 438 nm with 0.1 % addition of IPA. The limit of detection (LOD) of water in CH₃CN, DMF, THF and EtOH by TPA-C revealed 0.02, 0.7, 0.08 and 0.77 %, respectively. The LOD of IPA sensing in n-PA is 0.05 % and indicated the very efficient sensing and distinguishing propanol isomers. Thus, simple triphenylamine acid showed excellent water sensing and propanol isomers discrimination that could be attributed to the twisted intramolecular charge transfer (TICT) formation.

01 Jul 2024·Methods and Applications in Fluorescence

A simple light path modifying device to reduce scattering in front-face fluorescence spectra

Article

Author: Peters, Frank B ; Rapp, Andreas O

AbstractThis technical note presents a device to diminish scattering signal in front-face fluorescence spectra while obtaining fluorescence signal. The beam path in a commercial fluorescence spectrometer was modified by two deflecting mirrors, leading reflections away from the sensor. This light path modifying (LPM) device was tested with two fluid and three solid substances, where the scattering-to-fluorescence ratio improved by a factor of 1.7 to 7.6. The spectra obtained with the LPM were much clearer, and distortion of the fluorescence peaks was avoided. Scans of quinine sulphate complied well with reference spectra.

1

News (Medical) associated with Quinine Sulfate

06 Nov 2023

·www.prnewswire.com

Designs for Health Launches Innovative Probiotic Toothpaste, PerioBiotic™ Silver

Leading supplement brand debuts the only probiotic toothpaste suitable for sensitive teeth PALM COAST, Fla., Nov. 6, 2023 /PRNewswire/ -- Designs for Health, the expert-recommended and preferred brand for high-quality, professional strength, research-backed supplements, and recipient of the 2023 Top Nutraceutical Company award ** today announced the launch of PerioBiotic™ Silver, a fluoride-free probiotic toothpaste formulated with a unique combination of ingredients to support tooth enamel strength, brighten your smile, and support overall oral health.* This product joins Designs for Health's growing line of oral health solutions including PerioPull™ and Periommune™. PerioBiotic™ Silver features Kalident, a nano-hydroxyapatite, purified silver, CoQ10, grape seed extract, and Dental-Lac™, a strain of Lactobacillus paracasei. Dental-Lac™ has been shown in clinical research to help support a healthy balance of bacteria in the mouth and overall periodontal health.* Similar to the role of probiotics in the gastrointestinal tract, beneficial oral bacteria may help maintain dental and oral health. Purified silver may support overall oral wellness, CoQ10 may help support gum health, and grape seed extract may help healthy inflammatory support.* Two unique functional ingredients in this formula are calcium hydroxyapatite and hydrated silica. Hydroxyapatite is the primary mineral component of healthy tooth enamel, which can be worn down over time by acidic foods and drinks, harsh orthodontic glues and braces, and microbial imbalances within the mouth. Incorporating calcium hydroxyapatite into one's daily routine may help promote healthy tooth enamel and overall shine. Hydrated silica may possess natural cleaning properties and promote the teeth's natural brightness. Additionally, instead of using traditional harsh sulfates, this formula contains coco betaine, a coconut-sourced foaming and cleansing agent, and is suitable for sensitive teeth. "Since fluoride was added to toothpaste in the 1950s, not much has changed in the way of true innovation in the toothpaste category, which is why we are thrilled to announce the launch of our unique PerioBiotic™ Silver formulation," said Founder and Chairman Jonathan Lizotte at Designs for Health. "The latest science shows a healthy mouth begins with a balanced oral microbiome, which is why we have meticulously formulated it to exclude harsh irritants, toxins, and foaming and whitening agents that could compromise one's oral health. The final product is a culmination of clinically studied ingredients based on the latest research to help design a healthier smile for all." Designs for Health began in 1989 as a small educational services company with deep roots in natural medicine – and big ambitions to revolutionize the industry. More than 30 years later, the company is pioneering new approaches to nutritional science, breaking barriers in quality standards, and ultimately transforming the healthcare ecosystem. Through a robust product pipeline and a diverse portfolio of more than 300 nutritional products, Designs for Health is leading the charge in the natural and integrative medicine movement to design a well world for all. PerioBiotic™ Silver contains no fluoride, sodium lauryl sulfate, or saccharin. It is free of BPAs, parabens, synthetic colors, gluten, dairy, and synthetic sweeteners, and is vegetarian and non-GMO. It comes in spearmint and lemon flavors and is available to purchase at . To learn more about Designs for Health and its comprehensive portfolio of products, including its line of oral health products, visit . Please tune in to Designs for Health's new podcast, Conversations for Health, and immerse yourself in the current landscape of Functional Medicine to empower you to design a well world with us. About Designs for Health, Inc. Family-owned Designs for Health, Inc. offers high-quality dietary supplements and functional foods to healthcare professionals and their patients. Guided by its founding philosophy of "Science-First™," the company holds an unwavering commitment to creating research-driven formulations with meaningful quantities of functional ingredients that maximize the potential for successful health outcomes. For over 30 years, Designs for Health has been many healthcare professionals' trusted source for not only product innovation but also leadership in clinical education and practice development solutions. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. **Top Nutraceutical Company awarded by Food Business Review Contact: 5WPR 212-999-5585 [email protected] SOURCE Designs for Health

100 Deals associated with Quinine Sulfate

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External Link

KEGG	Wiki	ATC	Drug Bank
D02262	Quinine Sulfate	P01BC01	DB00468

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Malaria, Falciparum	US	Sun Pharmaceutical Industries, Inc.	12 Aug 2005
Malaria	CN	Grand Pharmaceutical Group	-

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Renal Insufficiency	NDA/BLA	US	Mutual Pharmaceutical Co., Inc.	01 Nov 2007

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02630472 (QSIND, CTgov)	Phase 1/2	Rhinitis \| Chronic sinusitis	10	Quinine Sulfate (Quinine Sulfate)	bswmtscldr(eejzbywqpj) = cdzrcovici ewpaskvvbs (tzwmrgltcl, pazwazpodg - rkiscktlfo) View more	-	13 Mar 2019
				Placebo (Placebo)	bswmtscldr(eejzbywqpj) = iybuvxwgpa ewpaskvvbs (tzwmrgltcl, hpkahdumnw - aqehlnisqy) View more
NCT00726414 (CTgov)	Phase 1	-	22	Quinine Sulfate (Quinine Sulfate Under Fasted Conditions)	byxmfxolyg(bkrldamrba) = kcffgwjxlc mzlgvhmdxe (raghluuxra, imojjrhodx - mjvbbkfmub) View more	-	03 Feb 2010
				Quinine Sulfate (Quinine Sulfate Under Fed Conditions)	byxmfxolyg(bkrldamrba) = renbneesnj mzlgvhmdxe (raghluuxra, zmudyztknl - sncccrwtfp) View more
NCT00727272 (CTgov)	Phase 1	-	27	Quinine Sulfate (Treatment A - Quinine Sulfate 324 mg Caps, Fasting Conditions)	tgaqzheszb(qeklbcdpgv) = gkfwykwnuk aeqhihswyt (jeiwappdme, rvzxqtitok - dihhlevjon) View more	-	30 Dec 2009
				Quinine Sulfate (Treatment A, Dose Adjusted to 300 mg)	tgaqzheszb(qeklbcdpgv) = hoshtblgsm aeqhihswyt (jeiwappdme, glcjgrkwck - qvjmojnelq) View more
NCT00726895 (CTgov)	Phase 1	-	24	Quinine Sulfate (Treatment A - Quinine Sulfate Capsules (1 x 324 mg Dose))	(pvvfhiafuo) = sfdqatobbn cozgoinive (svudnnlexe, monmnwiitl - zxvlakcdro) View more	-	30 Dec 2009
				Quinine Sulfate (Treatment A, Dose Adjusted to 2 x 324 mg)	(pvvfhiafuo) = ztmyvefxcl cozgoinive (svudnnlexe, fojdiuybyu - khppfmwbsn) View more
NCT00785486 (CTgov)	Phase 1	-	24	Midazolam Alone	jrwonhaipl(zwwtmksccn) = eyhxhetxra gfuuyzqftg (lolwcjacko, hidyslqbuc - gdvatqymdr) View more	-	08 Jul 2009