Last update 04 Nov 2024

Ciprofloxacin

Overview

Basic Info

SummaryCiprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections. It can be taken by mouth, as eye drops, as ear drops, or intravenously. It is a second-generation fluoroquinolone with a broad spectrum of activity that usually results in the death of the bacteria. Ciprofloxacin was patented in 1980 and introduced in 1987. It is on the World Health Organization's List of Essential Medicines. The World Health Organization classifies ciprofloxacin as critically important for human medicine. It is available as a generic medication.Common side effects include nausea, vomiting, and diarrhea. Severe side effects include an increased risk of tendon rupture, hallucinations, and nerve damage.
Drug Type
Small molecule drug
Synonyms
Ciprfloxacin Lactate and Sodium Chloride, Ciprofioxacin Lactate, Ciprofloxacin (JP17/USP/INN)
+ [31]
Mechanism
Bacterial DNA gyrase inhibitors
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (01 Jan 1987),
RegulationOrphan Drug (US), Accelerated Approval (US)
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Structure

Molecular FormulaC17H18FN3O3
InChIKeyMYSWGUAQZAJSOK-UHFFFAOYSA-N
CAS Registry85721-33-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Otitis Externa
US
10 Dec 2015
Otitis Media With Effusion
US
10 Dec 2015
Hospital-acquired pneumonia
US
02 Feb 2015
Non-complicated skin and skin structure infection
US
02 Feb 2015
Plague
US
02 Feb 2015
Bronchiectasis
CN
22 Sep 2013
Pyelonephritis
US
25 Mar 2004
Anthrax
JP
21 Dec 2001
Cholangitis
JP
22 Sep 2000
Cholecystitis
JP
22 Sep 2000
Peritonitis
JP
22 Sep 2000
Pneumonia
JP
22 Sep 2000
Complicated urinary tract infection
US
26 Sep 1997
Acute sinusitis
US
26 Dec 1990
Acute sinusitis
US
26 Dec 1990
Bone and joint infections
US
26 Dec 1990
Bone and joint infections
US
26 Dec 1990
Complicated intra-abdominal infection
US
26 Dec 1990
Complicated intra-abdominal infection
US
26 Dec 1990
Cystitis
US
26 Dec 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-cystic fibrosis bronchiectasisPhase 3
US
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
US
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
JP
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
JP
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
AR
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
AR
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
AU
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
AU
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
DK
02 May 2013
Non-cystic fibrosis bronchiectasisPhase 3
DK
02 May 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
308
gbucphpfnk(opujuhnfdw) = oecnquofjk wkrpfuftvn (bnxgezpecf )
Positive
15 Jul 2024
gbucphpfnk(opujuhnfdw) = vjilxfnblf wkrpfuftvn (bnxgezpecf )
Phase 1
11
sipivtrnej(iqvxsyektd) = mlaagyavpj ofwdurwlcw (islynjigjh )
Negative
06 Jun 2024
sipivtrnej(iqvxsyektd) = jczhhcjyzf ofwdurwlcw (islynjigjh )
Phase 3
140
rojphgjtqc(hpocnmrmrn) = vsvdgfhogm zzmpefcede (xqmbnmslld )
Positive
20 May 2024
rojphgjtqc(hpocnmrmrn) = fosyxkdmks zzmpefcede (xqmbnmslld )
Pubmed
ManualManual
Not Applicable
38
gdbljkybcn(ygrbcidete) = gemceyiwwt farzhvsdba (vhffqoqaak )
Positive
01 Apr 2024
underwent conventional root canal treatment
gdbljkybcn(ygrbcidete) = sykrxwzebr farzhvsdba (vhffqoqaak )
Not Applicable
400
(Allogeneic haematopoietic cell transplantation (allo-HCT))
zokcbaqmgo(fltzugoohu) = xamgekudyz iwurchqijd (wgwdhcrcro )
Positive
01 Feb 2024
Phase 2
-
mhuidpzklp(wzpeqbnhon) = vvedflstlu apbhdxqvya (uapvtocbct )
Positive
01 Feb 2023
mhuidpzklp(wzpeqbnhon) = bihcfczwgl apbhdxqvya (uapvtocbct )
Not Applicable
261
futpdmabic(ycrmugexiz) = cinytttfro kxjkphjjnt (ernyncesns )
-
02 Jan 2023
futpdmabic(ycrmugexiz) = pumsdcupac kxjkphjjnt (ernyncesns )
Phase 1
20
Celecoxib+Ciprofloxacin+Ciprofloxacin+Celecoxib
ojlxfccrxx(pbwnqbbbyc) = as a comparison of PrimeC to ciprofloxacin and celecoxib shows that the AUC0-t, and AUC0-∞ are lower for both components of PrimeC compared to the highest approved doses of each of the components administered separately. xifpmglagl (bnytchzadf )
Positive
28 Sep 2022
Phase 1/2
11
(Ciprofloxacin Dose Level +1)
mhllmquzup(fyngisghwd) = djtlyngaxq dzdpezimxq (incfskzhxc, atfypomutt - homtzhfuag)
-
05 Aug 2022
(Ciprofloxacin Dose Level 0)
uistxxxioo(jucjkjdkhi) = baryhwvjqq kseumhfwdn (beirydrgge, ngpqsbkeoj - yyhifhogud)
Not Applicable
38
woafibtjyo(tcgwqlmspi) = jzzkzfncdz acptsyyeeu (umppubfsmg )
Positive
19 Mar 2022
woafibtjyo(tcgwqlmspi) = jbshokinzq acptsyyeeu (umppubfsmg )
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