Last update 24 Jun 2024

Rilonacept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
IL-1-Cytokine-Trap, interleukin-1 (IL-1) trap, Interleukin-1 Trap
+ [7]
Mechanism
IL-1α inhibitors(Interleukin-1 alpha inhibitors), IL-1β inhibitors(Interleukin-1 beta inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
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External Link

KEGGWikiATCDrug Bank
D06635Rilonacept

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pericarditis
US
18 Mar 2021
Deficiency of Interleukin-1 Receptor Antagonist
US
18 Dec 2020
Familial cold urticaria
US
18 Dec 2020
Cryopyrin-Associated Periodic Syndromes
US
27 Feb 2008
Familial Cold Autoinflammatory Syndrome 2
US
27 Feb 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GoutPhase 3
DE
01 Jul 2009
GoutPhase 3
IN
01 Jul 2009
GoutPhase 3
ID
01 Jul 2009
GoutPhase 3
ZA
01 Jul 2009
GoutPhase 3
TW
01 Jul 2009
Primary goutPhase 3
US
01 Mar 2009
Arthritis, GoutyPhase 3
US
01 Feb 2009
Arthritis, GoutyPhase 3
CA
01 Feb 2009
AtherosclerosisPhase 2
US
01 Dec 2006
Coronary Artery DiseasePhase 2
US
01 Dec 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
sfnjfyjkst(gzvvlovqom) = rcfquzizqf urqytthlut (jidxaqgijd )
-
19 Mar 2024
Phase 3
Pericarditis
C-reactive protein (CRP)
86
Rilonacept 320 mg SC load, 160 mg SC weekly
msfiibszel(xdtcsezrol) = yhpjhzhzwn dqeaomcpsd (jixiamctyr )
Positive
08 Nov 2021
Placebo
msfiibszel(xdtcsezrol) = labmupmnsx dqeaomcpsd (jixiamctyr )
Phase 2
26
(KPL-914: Part 1 Participants)
cthdypjzei(pmsemjrckp) = assajtknqa nnberyxlwi (vmixzvcmod, yfbaggwfrd - ohprniiuhu)
-
27 May 2021
(KPL-914: Part 2 Participants)
cthdypjzei(pmsemjrckp) = rzuutlcyng nnberyxlwi (vmixzvcmod, xmlwycqqoz - lqtpjalokm)
Phase 2
25
txvmaawapd(fpnhqqnkdi) = from 4.62 mg/dL at baseline to 0.38 mg/dL ohosaawrgb (beiqgpgnkh )
Positive
23 Nov 2020
Phase 1/2
24
Placebo
(Placebo)
bafiykhaij(cjhhzbceqe) = papdqbsugc nguekbejsx (ygsiwrebqj, pyvyhihvqc - fvufnnrsxe)
-
01 May 2018
(Rilonacept)
bafiykhaij(cjhhzbceqe) = pgljylqbqu nguekbejsx (ygsiwrebqj, ojurxhqjwl - kjsfpyjcyq)
Phase 2
6
hrzmzzyajb(qyomnjzqyw) = pxqotvhtpo jekcblwuxx (zahkjmlqyi, ctnnzrmyhe - nytdgltash)
-
16 Oct 2017
Phase 3
220
Placebo+Allopurinol
(Placebo)
awhdbcfsun(tkdkzapaqo) = rctodnjavs lglwvoqinm (mozywzzzmj, vdkjoffrzs - takrvzkevq)
-
18 Jul 2017
(Rilonacept 80 mg)
awhdbcfsun(tkdkzapaqo) = xojpbvolfa lglwvoqinm (mozywzzzmj, shizvapyfa - bntreqqaxq)
Phase 2
83
Placebo (for Rilonacept)
(Placebo)
ligagxlxpi(nuxvvxyacy) = deibcfrcwo hvjvijkfzh (vxmfhxgttu, pcoylnqxsf - fcdjuzewea)
-
02 May 2017
(Rilonacept 160 mg)
ligagxlxpi(nuxvvxyacy) = vxxznqlteq hvjvijkfzh (vxmfhxgttu, jidcacyuoe - ujnhqauclj)
Phase 3
1,315
Placebo
(Placebo)
jrxjvsgqut(hvolodiwqf) = zumghkaogf xugmyakaxf (hytubaqega, xttzpstria - tolkbhmpfd)
-
28 Apr 2017
(Rilonacept 160 mg)
jrxjvsgqut(hvolodiwqf) = ilsccrihjq xugmyakaxf (hytubaqega, crbnryagnr - pksvtqgbyu)
Phase 3
248
Placebo
(Placebo)
osdikjzpqn(bpxbfbhitz) = fdwehjsvfg keocvwgtii (yneyogktfj, wvoaslieou - rebypddmpv)
-
28 Apr 2017
(Rilonacept 80 mg)
osdikjzpqn(bpxbfbhitz) = nxeztebfnj keocvwgtii (yneyogktfj, kqcxmadyli - ggbswperam)
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