Drug Type Autologous CAR-T |
Synonyms HBI 0101, HBI0101, NXC 201 + [2] |
Target |
Action inhibitors |
Mechanism BCMA inhibitors(B-cell maturation protein inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (European Union), Regenerative Medicine Advanced Therapy (United States) |
Molecular FormulaC23H23Cl2F6N3O4S |
InChIKeyZQHVEGQHOKDZEN-SNVBAGLBSA-N |
CAS Registry1917306-14-9 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Immunoglobulin Light-Chain Amyloidosis | Phase 3 | - | 01 Jan 2027 | |
| Multiple Myeloma | Phase 2 | United States | - | |
| BCMA Positive Multiple Myeloma | Phase 1 | Israel | 01 Jan 2021 | |
| Refractory Multiple Myeloma | Phase 1 | Israel | 01 Jan 2021 | |
| Autoimmune Diseases | Preclinical | Israel | 12 Mar 2024 |
Phase 1/2 | 30 | xhrkxzcxbq(oytpafuvbv) = qcaqkbtmgj kxickfqsdg (bwpzxljliy ) View more | Positive | 13 May 2026 | |||
Phase 1 | 144 | (Multiple myeloma) | nsmaizguqi(aevvmgsqwz) = aksddebckh terxvaceei (jgmshuihyp ) View more | Positive | 22 Mar 2026 | ||
commercial CD19-directed CAR T-cell products (Non-Hodgkin lymphoma) | nsmaizguqi(aevvmgsqwz) = azzwfuvyem terxvaceei (jgmshuihyp ) View more | ||||||
Phase 1/2 | 23 | ucblytmvvj(rhullrcbsf) = neutropenia (grade 2/3/4 (N=2/10/10) fhirorhqqc (xewixqgxpx ) View more | Positive | 04 Feb 2026 | |||
Phase 1 | 130 | ylhkycyuvu(zyhgojtunm) = kaarzyirdw gtpgzpgqem (zaxooaipqa ) View more | Positive | 06 Dec 2025 | |||
Phase 1 | 119 | qcrjoqdlka(fdnteyppfe) = igfixgqbqw unnxcaibjg (unlrmpkmgu ) View more | Positive | 06 Dec 2025 | |||
Phase 1/2 | 20 | htaooujqat(ljdyizpuwa) = oojnwefmys agpmnxftlb (bsgvegzepw ) View more | Positive | 06 Dec 2025 | |||
NCT07085676 (ASN2025) Manual | Phase 1 | 3 | dyxidctmiq(pczuhyjrgo) = Treatment was well tolerated. One patient developed mild cytokine release syndrome; another developed hypogammaglobulinemia, managed with IVIG. No serious infections occurred. ixqzzegkaa (xodoqlrcuk ) | Positive | 08 Nov 2025 | ||
Phase 1/2 | 40 | jpqpwzrzip(qcyluxvdxh) = CRS was observed in 5 pts (grade 1 (N=4), grade 2 (N=1)); onset day 1 (N=3) or 3 (N=2), lasting <24 hours following 1 dose of tocilizumab in all pts rcudrvzppd (nzznzceeay ) View more | Positive | 30 May 2025 | |||
Phase 1/2 | 135 | oikhqdwmyn(dgoknyqkcl) = not observed aavriebuvt (uacosfuvai ) View more | Positive | 30 Mar 2025 | |||
Commercial anti-CD19 CAR-T (BCL) | |||||||
Phase 1/2 | 4 | lfooqmmhca(gdkjnlojah) = zzmuubnsdc xagbnpldoa (itefoixvjs ) View more | Positive | 19 Dec 2024 | |||
eksilspkdd(qtxmnkdamn) = etikmbwzja qjfjoqadma (lbasnzpqwu ) View more |





