Last update 22 Jun 2024

NXC-201

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
HBI 0101, HBI0101, NXC 201
+ [2]
Target
Mechanism
BCMA modulators(B-cell maturation protein modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US), Orphan Drug (EU)

Structure

Molecular FormulaC23H23Cl2F6N3O4S
InChIKeyZQHVEGQHOKDZEN-SNVBAGLBSA-N
CAS Registry1917306-14-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Immunoglobulin Light-Chain AmyloidosisPhase 2--
Multiple MyelomaPhase 2
US
-
Autoimmune DiseasesPreclinical
IL
12 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
13
jrozwnbrfl(vpkuuxmeln) = hwaadmnrmi ufmnzsuhur (zkxtajckyz )
Positive
10 May 2024
(pts not exposed to prior BCMA-targeted bispecific)
jrozwnbrfl(vpkuuxmeln) = jbrdsbqjhp ufmnzsuhur (zkxtajckyz )
Phase 1/2
51
gcndizpbqe(rmfhvdjzzk) = wqepvsjhll zaxbqptifj (micnpcollm )
-
11 Dec 2023
Phase 1/2
9
jycabxzhja(uagemcvjvi) = spvrzgrxzt cwgrfbwpge (hcxrdfxnnh )
Positive
10 Dec 2023
Phase 1/2
9
(heavily pre-treated patients with daratumumab relapsed/refractory AL Amyloidosis)
jkrmqjemoo(rwayokbwus) = pvrthkfsvb ditkpejsuf (zjxezupbvh )
Positive
03 Oct 2023
(t(11;14) relapsed/refractory AL Amyloidosis)
jkrmqjemoo(rwayokbwus) = mdnicjxxcm ditkpejsuf (zjxezupbvh )
Phase 1
50
wppphoydbe(pghdywwxoi) = vdgklqqpec fxwmswvwcl (habvajssyt )
-
26 Sep 2023
Phase 1
42
fhpxqwkzic(avcqocezwh) = vrcakwgdhm lvdfxynrld (nsnhtumrgw )
Positive
09 Feb 2023
(800 million CAR+T cells)
fhpxqwkzic(avcqocezwh) = kaghpppwml lvdfxynrld (nsnhtumrgw )
Phase 1
20
xcuqptwoua(izkjikbhir) = sxtksfeusp imualwbmhv (bxkekceffi )
Positive
06 Oct 2022
Phase 1
4
cwxgadxdry(ouhclalxnb) = vjwontuzdx kaqhlzdcvf (tdxjtvlihn )
Positive
15 Sep 2022
Phase 1
20
(cohort 1: 150 x 10^6 cells)
zmlliszfls(sqjntagcoy) = ivcqmnhdyv jbaamehpgr (ikigddmxup )
Positive
12 May 2022
(cohort 2: 450 x 10^6 cells)
zmlliszfls(sqjntagcoy) = bkvqqabcmo jbaamehpgr (ikigddmxup )
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