This purpose of this study is to understand the types of bacteria that are in the bladder and vagina in patients with overactive bladder (OAB) symptoms and understand if the types of bacteria change when with the use of estrogen in the vagina. The investigators are also trying to understand how estrogen influences the body's ability to make substances called peptides that can kill bacteria.

Start Date01 Sep 2016

Sponsor / Collaborator

Kimberly-Clark Corp.

NCT00805207

/ CompletedNot ApplicableIIT

Sex Steroids, Sleep, and Metabolic Dysfunction in Women

Increased plasma triglyceride concentration is a common feature of the metabolic abnormalities associated with obesity and a major risk factor for cardiovascular disease. Obesity is a major risk factor for two conditions that appear to be increasing in prevalence in women: the polycystic ovary syndrome (PCOS) and sleep disordered breathing. PCOS affects 5-8% of women. Sleep disordered breathing affects up to 10% of women. Obstructive sleep apnea (OSA) is the most common cause for sleep disordered breathing and particularly prevalent in obese women with PCOS (
50%). Both PCOS and OSA augment the increase in plasma triglyceride (TG) concentration associated with obesity, and the effects of PCOS and OSA on plasma TG concentration appear to be additive. The mechanisms responsible for the adverse effects on plasma TG metabolism are not known. The primary goal of this project, therefore, is to determine the mechanisms responsible for the increase in plasma TG concentration in obese women with PCOS and OSA. It is our general hypothesis that alterations in the hormonal milieu that are characteristic of these two conditions are, at least in part, responsible for the increase in plasma TG concentration in obese women with the conditions. Furthermore, we hypothesize that the hormonal aberrations characteristic of the two conditions are particularly harmful to obese, compared with lean, women.
The effects of PCOS on skeletal muscle protein metabolism are also not known. However, sex hormones are thought to be important regulators of muscle protein turnover suggesting that muscle protein metabolism is likely to be affected by PCOS. We will examine this by determining the effect of individual sex hormones on muscle protein metabolism and hypothesize that testosterone administration will stimulate muscle protein metabolism while estrogen and progesterone administration will inhibit muscle protein metabolism.

Start Date01 Sep 2007

Sponsor / Collaborator

Washington University School of Medicine

NCT00694733

/ Unknown statusNot ApplicableIIT

Regulation of Cortisol Metabolism and Fat Patterning

The purpose of this study is to determine if estrogen or testosterone can affect cortisol levels and where fat builds up in our bodies.

Start Date01 May 2005

Sponsor / Collaborator

Oregon Health & Science University

[+1]

100 Clinical Results associated with Alfatradiol

100 Translational Medicine associated with Alfatradiol

100 Patents (Medical) associated with Alfatradiol

2,569

Literatures (Medical) associated with Alfatradiol

01 Apr 2025·SEPARATION AND PURIFICATION TECHNOLOGY

Using artificial neural networks to elucidate retention interactions on stationary phases with amine moieties dedicated to supercritical fluid chromatography

Author: Plachka, Katerina ; Gazarkova, Tatana ; Pilarova, Veronika ; Plachká, Kateřina ; Nováková, Lucie ; Pilařová, Veronika ; Svec, Frantisek ; Švec, František ; Garrigues, Jean-Christophe ; Novakova, Lucie ; Gazárková, Taťána

The retention mechanisms of small mols. on a wide range of stationary phases using different mobile phase compositions are one of the most discussed topics in current state-of-the-art supercritical fluid chromatog. (SFC).Although various theories have been published on retention behavior, prediction, and stability over time, an in-depth insight into the mechanisms is still lacking.Our study focused on the description of the retention mechanisms on columns with amine moieties, i.e., 2-ethylpyridine, 2-picolylamine, 1-aminoanthracene, and diethylamine, dedicated to SFC, using three different compositions of organic modifier, i.e., methanol, methanol + 10 mmol/L NH₃, and methanol + 2% H₂O, in CO₂.An extensive set of analytes characterized by more than 200 mol. descriptors was used.The importance of the effect of each mol. descriptor on the retention behavior was determined by artificial neural networks.Thus, the descriptors increasing and/or decreasing retention on individual columns using different mobile phase compositions were defined.The data collected over one year of column use were statistically evaluated to describe the retention behavior of small mols. on the tested stationary phases using three organic modifiers and to describe the changes in retention behavior over time.As the development of the SFC method can be laborious and time-consuming, this publication offers a detailed description of the interactions taking place between the analyte and the SFC stationary phase.Understanding these fundamental processes will enable faster development of SFC methods using quality-by-design principles.

01 Mar 2025·ARCHIVES OF ORAL BIOLOGY

Characterization of craniofacial tissue aging in genetically diverse HET3 male mice with longevity treatment of 17-alpha estradiol

Article

Author: Townsend, Kristy L ; Chufar, Emma ; Willows, Jake W ; LaVerde, Leah ; Alsabbagh, Rami ; Peters, Sarah B

OBJECTIVE:

The objective of our study was to 1) characterize craniofacial tissue aging in the new, genetically diverse HET3 mouse model; and 2) ascertain whether increased longevity with 17-alpha estradiol (17αE2) treatment in male mice also improved the health of these tissues. The HET3 mice are a four-strain cross preferred and recommended by the National Institute of Aging to identify longevity treatments and test their ability to reduce age-related pathologies. Previous reports demonstrated increased longevity in male, but not female, HET3 mice with 17αE2 administration.

DESIGN:

Male mice were raised to approximately 8 months (young), 16 months (middle-aged), and 25 months (old). Middle-aged and old mice were administered a diet supplemented with 17αE2 for 19 weeks. We quantified craniofacial tissue volume and density changes with micro-computed tomography followed by histology.

RESULTS:

Micro-CT showed that the alveolar bone volume and density did not change with age or treatment. Enamel volume and density changed with age but not treatment. Histology revealed region-specific degeneration of periodontal ligaments (PDLs) with age. Cellular cementum demonstrated age-related density decreases but no change in volume. However, cementum volume and density increased with 17αE2 treatment. Dentin volume increased with age whereas density decreased with age, which were attenuated by 17αE2 treatment.

CONCLUSIONS:

The HET3 mice present an excellent model with which to study the heterogeneous nature of tooth aging and the effects of longevity interventions. We provide novel data on how 17αE2 improves healthspan by modifying age-related changes in the molar dentin and cementum of male mice.

01 Feb 2025·AQUACULTURE

Comparative study on the role of various sterols in enhancing ovarian development and metabolic functions in Pacific white shrimp (Litopenaeus vannamei) broodstock

Author: Li, Erchao ; Wen, Muchun ; Liang, Xiaolong ; Song, Yongqiang ; Han, Fenglu ; Gao, Xiuju ; Xiao, Xianming ; Xu, Chang

In this study, the Pacific white shrimp (Litopenaeus vannamei) broodstock was considered to rely on dietary sterols for ovarian development because of the inability of the animals to synthesize sterols endogenously.Therefore, we investigated the effects of cholesterol, ergosterol, β-sitosterol, and fucosterol as sterol sources, compared with a control group lacking sterols, on the growth, reproduction, and metabolism of shrimp for a 28-day feeding trial, with an average weight of 32.28 ± 2.00 g in female L. vannamei broodstock.The results demonstrated that cholesterol supplementation significantly enhanced shrimp growth, the gonadosomatic index, and yolk particle deposition, outperforming the other sterol groups and the control group.Notably, while broodstock in the ergosterol group presented the greatest weight gain and yolk granule deposition, they did not achieve the same level of gonadal development or metabolic efficiency as those receiving cholesterol.Addnl., the β-sitosterol group demonstrated a favorable hepatosomatic index but still fell short of the benefits provided by cholesterol.Cholesterol has unique advantages in promoting growth and ovarian development, which may be attributed to its more efficient metabolic utilization and enhanced hormone synthesis, as indicated by the significantly higher serum levels of 17β-estradiol and progesterone in the cholesterol group.Furthermore, cholesterol supplementation significantly upregulated vitellogenin mRNA expression in the hepatopancreas and ovaries, thereby promoting ovarian maturation.Addnl., γ-linolenic acid and 9,10-epoxyoctadecenoic acid were significantly upregulated in the cholesterol group, facilitating ovarian lipid accumulation.In conclusion, the use of cholesterol as a sterol source in the diet significantly promoted the growth and ovarian development of L. vannamei by regulating lipid metabolism and hormone synthesis.

100 Deals associated with Alfatradiol

External Link

KEGG	Wiki	ATC	Drug Bank
D07121	Alfatradiol	C01EA01 G04BE01	DB05846

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Alopecia	-	-	-

Developing

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Indication	Highest Phase	Country/Location	Organization	Date
Alzheimer Disease	Phase 1	US	-	-
Friedreich Ataxia	Phase 1	US	-	-
Parkinson Disease	Phase 1	US	-	-
Retinitis Pigmentosa	Discovery	US	Global Gaming Technologies Corp.	-

Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02835846 (FUM, CTgov)	Phase 4	Urinary Incontinence \| Nocturia \| Urinary Bladder, Overactive	35	Estrogen Cream	wsscqwhfhh(vijkrsgjjl) = kpdyuoixhn jonnhmmwqo (smiieesccq, ogtsuqimgl - vxjhyyrmxa) View more	-	23 Sep 2021

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