Last update 21 Nov 2024

Buparlisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Buparlisib (USAN/INN), Buparlisib hydrochloride
+ [4]
Mechanism
PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kγ inhibitors(Phosphatidylinositol 3 kinase gamma inhibitors)
+ [1]
Therapeutic Areas
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN), Fast Track (US)
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Structure

Molecular FormulaC18H21F3N6O2
InChIKeyCWHUFRVAEUJCEF-UHFFFAOYSA-N
CAS Registry944396-07-0

External Link

KEGGWikiATCDrug Bank
D10584Buparlisib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2-negative breast cancerPhase 2
CA
01 Aug 2012
HER2-negative breast cancerPhase 2
US
01 Aug 2012
HER2-negative breast cancerPhase 1
ZA
01 Aug 2012
HER2-negative breast cancerPhase 1
GB
01 Aug 2012
HER2-negative breast cancerPhase 1
KR
01 Aug 2012
HER2-negative breast cancerPhase 1
AT
01 Aug 2012
HER2-negative breast cancerPhase 1
RU
01 Aug 2012
HER2-negative breast cancerPhase 1
HK
01 Aug 2012
HER2-negative breast cancerPhase 1
JP
01 Aug 2012
HER2-negative breast cancerPhase 1
AU
01 Aug 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
23
Intensity-modulated radiotherapy (IMRT)+BKM120+Cisplatin
(Dose Level 1)
wlcjvrqtsp(ameclsetry) = bzzqokubpe kpcfmmjtss (oedmxpzdie, lgeoxscyox - hrixeqavlp)
-
05 Nov 2024
Intensity-modulated radiotherapy (IMRT)+BKM120+Cisplatin
(Dose Level 2)
wlcjvrqtsp(ameclsetry) = nqtfjhnfww kpcfmmjtss (oedmxpzdie, tuivkyqqrz - jnqhudujhv)
Phase 2
10
(xzzsrfnzrg) = pwtftygdpj bzrzfskktn (egjgcfcvzh, wbgixejkms - jwmmpjjvxi)
-
01 Feb 2022
Phase 2
14
(chreblbrry) = rxndiyvnpm dslmuaqmhg (tvolcalcce )
Positive
01 Jan 2022
Phase 1
37
(naqsxomiig) = pkxkqxduig eotzvxrxyh (yipfhzygbc )
-
06 Oct 2021
Phase 1
39
(lyccymrazm) = tbptvgyqax iorllbmdgo (ylrknvqnez )
-
01 Jul 2021
Phase 2
19
zfdwjxnpgy(pzzhearcjr) = lpltektjuu wtugdolnsg (bqgejubybr, cmuxxhgsdc - ylegxddyuj)
-
21 Jun 2021
Phase 2
11
glpaecztip(hfywfnzgyc) = xnyupecwrv djoymqgdbr (iotggueiok, kwnxlkmyob - epgutafwzw)
-
13 Jan 2021
Phase 2
50
(qsqzhjoxun) = gdgasjkwne dtkyqwldkj (vsbpakyszz )
Negative
02 Nov 2020
Phase 2
50
(nemecuilrl) = zoqfbemama dccluimdtj (osrazrhlsi, gqbecujumz - fifrqatnxi)
-
28 Oct 2020
Phase 1/2
12
(fofnzwkqcn) = hbcvcsfgec ledxpzdopn (ndpqewykru, errgremcgd - adebjpbxrb)
-
27 Oct 2020
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