Last update 27 Mar 2025

Buparlisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Buparlisib (USAN/INN), Buparlisib hydrochloride, AN-2025
+ [4]
Action
inhibitors
Mechanism
PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), PI3Kβ inhibitors(Phosphatidylinositol 3 kinase beta inhibitors), PI3Kγ inhibitors(Phosphatidylinositol 3 kinase gamma inhibitors)
Therapeutic Areas
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Special Review Project (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC18H21F3N6O2
InChIKeyCWHUFRVAEUJCEF-UHFFFAOYSA-N
CAS Registry944396-07-0

External Link

KEGGWikiATCDrug Bank
D10584Buparlisib-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Squamous Cell Carcinoma of Head and NeckPhase 3
China
07 Apr 2021
Squamous Cell Carcinoma of Head and NeckPhase 3
China
07 Apr 2021
Squamous cell carcinoma of head and neck metastaticPhase 3
United States
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
China
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
Japan
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
Argentina
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
Australia
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
Belgium
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
Canada
12 Dec 2020
Squamous cell carcinoma of head and neck metastaticPhase 3
France
12 Dec 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Squamous Cell Carcinoma of Head and Neck
TP53 | NOTCH1 | PIK3CA ...
158
ziymfqgurt(bdchooqwoz) = dypmrtbtfj dzrbdhffko (sqnhlbgnsv )
Positive
14 Jan 2025
Placebo + Paclitaxel
anvhgbdyer(xzksyaasod) = efobpjeirp ucldishees (tcrgwmsiia )
Phase 1
23
Intensity-modulated radiotherapy (IMRT)+BKM120+Cisplatin
(Dose Level 1)
jqetxjviyi = xtfrhqxshz rfmtsznrnk (fdenqgciga, nxqiwsaysc - opmjjqdnfn)
-
05 Nov 2024
Intensity-modulated radiotherapy (IMRT)+BKM120+Cisplatin
(Dose Level 2)
jqetxjviyi = byhninfbmy rfmtsznrnk (fdenqgciga, keeunpjyys - eukzimnkpl)
Phase 2
10
gmiwmbvcfc = hqxfrasnzj fxfqmxjcav (exknnzsnps, wnygtzaqdd - gmuthpsmrb)
-
01 Feb 2022
Phase 2
14
dadkvynryb(nyeupqzkde) = hktrxbyzsw vatqepidcx (hcbqvamqed )
Positive
01 Jan 2022
Phase 1
37
nbbpfnppaf(mhrphfpvyd) = lkioulzuqi ejdxsgozhc (rhlifvlzwn )
-
06 Oct 2021
Phase 2
19
ljfvnnlfjl = afablsdiyl kzscopcink (kqeynrtcju, jsbrfemmww - hbfzntuhec)
-
21 Jun 2021
Phase 3
483
Buparlisib + Paclitaxel
tzllwuoike(mzqyosrtou) = kkokcqucxm tybuiavhlh (axaayovxfh )
Positive
28 May 2021
Paclitaxel alone
tzllwuoike(mzqyosrtou) = tsbmymtfpe tybuiavhlh (axaayovxfh )
Phase 1
29
Tamoxifen Citrate+Goserelin Acetate+Alpelisib
gdenhyihyl(netrdbosew) = xwucrgscbs phhksigsom (savihzlhnd )
Positive
15 Jan 2021
Tamoxifen Citrate+Goserelin Acetate+Buparlisib
gdenhyihyl(netrdbosew) = vknqizaxeo phhksigsom (savihzlhnd )
Phase 1
70
nqflwujhzv(blooubymkn) = cwrfpbntbg pjzjqdwnvf (ykcaccavsj, 9.8 - 46.7)
-
15 Jan 2021
Phase 2
11
naelugdcpc = wgoycwizyi mpvyfxvris (gbksfbawhb, hekvgrabxx - yakdsznfnz)
-
13 Jan 2021
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free