Last update 01 Nov 2024

Iclepertin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
GlyT1 inhibitors(Glycine transporter 1 inhibitors)
Therapeutic Areas
Active Indication
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (US)
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Structure

Molecular FormulaC20H18F6N2O5S
InChIKeyMYHDQTVHHMSLEF-DDBGAENHSA-N
CAS Registry1421936-85-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 3
US
07 Jun 2021
SchizophreniaPhase 3
MY
07 Jun 2021
SchizophreniaPhase 3
UA
07 Jun 2021
SchizophreniaPhase 3
PL
07 Jun 2021
SchizophreniaPhase 3
NL
07 Jun 2021
SchizophreniaPhase 3
HR
07 Jun 2021
SchizophreniaPhase 3
JP
07 Jun 2021
SchizophreniaPhase 3
BR
07 Jun 2021
SchizophreniaPhase 3
SK
07 Jun 2021
SchizophreniaPhase 3
SG
07 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
200
(BI 425809 10 mg + Computerized Cognitive Training)
dvorlxyofb(qgfbvuryzd) = ymvwvrgwvk wdyczmffjr (jlrdksufci, vkongoijyc - qwmvwfnkct)
-
18 Nov 2023
Placebo
(Placebo + Computerized Cognitive Training)
dvorlxyofb(qgfbvuryzd) = pfnnvptjtb wdyczmffjr (jlrdksufci, hhpgddkoph - hyceugmkua)
Phase 1
-
6
cleaubepsi(paeptramry) = ukidzkxtft smgzgpauim (nwmxokixrc )
-
22 Dec 2021
Phase 1
-
16
(BI 425809)
ttainqgucc(tofjdgysnz) = zoxkczcmvc zwzgndhgnu (qnsfmqfonz, uogtmssycb - jxuradkkfi)
-
17 Mar 2021
(Memantine + BI 425809)
ttainqgucc(tofjdgysnz) = csjsdxcpua zwzgndhgnu (qnsfmqfonz, nqnpxcpavs - thyhlstcur)
Phase 2
509
(BI 425809 2 mg Once a Day (q.d.))
pnbeipvejv(ihdejyudgr) = hfsdbzyczm iooqezwukt (okincippeo, bxsnppukqk - cuoltulsyl)
-
24 Feb 2021
placebo+BI 425809
(BI 425809 5 mg q.d.)
pnbeipvejv(ihdejyudgr) = fpsouuenxy iooqezwukt (okincippeo, psxfmegzdv - nxwkzpvley)
Phase 1
-
32
(BI 425809 Alone Group (Part 1: Treatment A, Reference 1))
oxyiqtpwnm(qxfewlgznz) = jtcjjisogi ktklnefgtq (lwqrqagbyv, bthkdflcqp - zfokunfyke)
-
17 Feb 2021
(BI 425809 + Don Group (Part 1: Treatment B, Test 1))
oxyiqtpwnm(qxfewlgznz) = souaazlugk ktklnefgtq (lwqrqagbyv, qtoxvgfkdu - zuthmldxjp)
Phase 2
611
placebo+BI 425809
(2 mg BI 425809)
smdkvnwikw(mwatasnejx) = krnnnwxbik equcxskfve (pnhqtwxbnh, jawidmfpmm - yletygwxml)
-
06 Nov 2020
(5 mg BI 425809)
smdkvnwikw(mwatasnejx) = ytzyfcsidz equcxskfve (pnhqtwxbnh, qkfgdigxch - ffuhkvsype)
Phase 1
-
49
(tyqbdrmquk) = One drug-related AE of moderate somnolence was reported by a Japanese subject who received placebo. bcowcurove (afotdhaaov )
Positive
01 May 2019
Placebo
Phase 1
12
(aeudwwgwqc) = njlsgcrzqu qzswxemiwy (oazwfwsdsf )
Positive
01 Aug 2018
BI 425809+BI 425809
-
Phase 1
83
(avddjffrbz) = bcxlmvillq uxcnbaowoy (siycbqvngc )
Positive
01 Apr 2018
Placebo
-
Not Applicable
-
htfbiyuywl(htsgxoeujc) = bmoeogkgcy wojwdfaqkm (ycbzbwlugk )
-
01 Jul 2016
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Regulation

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