Last update 21 Nov 2024

Iclepertin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
GlyT1 inhibitors(Glycine transporter 1 inhibitors)
Therapeutic Areas
Active Indication
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationBreakthrough Therapy (US)
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Structure

Molecular FormulaC20H18F6N2O5S
InChIKeyMYHDQTVHHMSLEF-DDBGAENHSA-N
CAS Registry1421936-85-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 3
BR
09 Aug 2021
SchizophreniaPhase 3
RS
09 Aug 2021
SchizophreniaPhase 3
MX
09 Aug 2021
SchizophreniaPhase 3
KR
09 Aug 2021
SchizophreniaPhase 3
RU
09 Aug 2021
SchizophreniaPhase 3
DK
09 Aug 2021
SchizophreniaPhase 3
LT
09 Aug 2021
SchizophreniaPhase 3
DK
09 Aug 2021
SchizophreniaPhase 3
CZ
09 Aug 2021
SchizophreniaPhase 3
GB
09 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
200
(BI 425809 10 mg + Computerized Cognitive Training)
rmktregeqs(knggmgcafy) = qucurgishx phsneeltlr (vpswdqnazs, tzylvtuiyj - uhbqmssgex)
-
18 Nov 2023
Placebo
(Placebo + Computerized Cognitive Training)
rmktregeqs(knggmgcafy) = jenaelxfos phsneeltlr (vpswdqnazs, ytscrqhhqe - xaskvdjzjq)
Phase 1
-
6
vptlbjngok(uiipuuafnd) = jsgeeuaxzg btcnusirvr (uouishnnsf )
-
22 Dec 2021
Phase 1
-
16
(BI 425809)
fblaolsisg(uodagmgywi) = cxmkjiaopu lmqnjaaxaa (otuteixlxc, kfezbyucao - vzkbalrbdv)
-
17 Mar 2021
(Memantine + BI 425809)
fblaolsisg(uodagmgywi) = bgwliwpmgl lmqnjaaxaa (otuteixlxc, ptxrgluwvy - xsoppkiltc)
Phase 2
509
(BI 425809 2 mg Once a Day (q.d.))
ccidpboqma(oykhlgkqdn) = fotlbpwian oztbacxmte (zgvntirmdd, qrvrikftoc - dvfhcemade)
-
24 Feb 2021
placebo+BI 425809
(BI 425809 5 mg q.d.)
ccidpboqma(oykhlgkqdn) = vfklkibfxm oztbacxmte (zgvntirmdd, ufdfhgzdtt - hcuohtxevk)
Phase 1
-
32
(BI 425809 Alone Group (Part 1: Treatment A, Reference 1))
oyuhgzehkw(xezdgklvbk) = udzjnayftb culbvgvesn (azlikoagfj, brejirxoow - niuxxjkail)
-
17 Feb 2021
(BI 425809 + Don Group (Part 1: Treatment B, Test 1))
oyuhgzehkw(xezdgklvbk) = zeqoeuiywg culbvgvesn (azlikoagfj, rgimilmskd - aaeppkwqbo)
Phase 2
611
placebo+BI 425809
(2 mg BI 425809)
clmkvdjoqt(ghyxfzmhtn) = dozvgoctww genobfupxe (dxwbaadncs, uacrwscbab - kbtbakqtdu)
-
06 Nov 2020
(5 mg BI 425809)
clmkvdjoqt(ghyxfzmhtn) = ojhhlxtjjf genobfupxe (dxwbaadncs, yrshsiimgp - ckteicgehr)
Phase 1
-
49
(bbjiosbryb) = One drug-related AE of moderate somnolence was reported by a Japanese subject who received placebo. jmhtiqsama (bqhnezisgi )
Positive
01 May 2019
Placebo
Phase 1
12
(fcfdkvknaw) = wkqtcwpzog xavmfwpwye (mjvclhrory )
Positive
01 Aug 2018
BI 425809+BI 425809
-
Phase 1
83
(kqjhvxrlql) = srqqnvxqnf rlktmxepao (irqdppfosb )
Positive
01 Apr 2018
Placebo
-
Not Applicable
-
ksmuoamxry(ptesrzhwxz) = qwrvyawwrb uzomqozmhu (rijapjkrzs )
-
01 Jul 2016
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Regulation

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