Last update 25 Jul 2025

Memantine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
memantine, Memantine hydrochloride (JAN/USP), D-145
+ [18]
Action
antagonists
Mechanism
NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Germany (11 Aug 2000),
Regulation-
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Structure/Sequence

Molecular FormulaC12H22ClN
InChIKeyLDDHMLJTFXJGPI-UHFFFAOYSA-N
CAS Registry41100-52-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alzheimer Disease
European Union
15 May 2002
Alzheimer Disease
Iceland
15 May 2002
Alzheimer Disease
Liechtenstein
15 May 2002
Alzheimer Disease
Norway
15 May 2002
Dementia
Germany
11 Aug 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dementia, VascularPhase 3
Russia
23 Jan 2018
Frontotemporal DementiaPhase 3
Canada
01 Oct 2007
Multiple Sclerosis, Relapsing-RemittingPhase 3
France
01 Sep 2005
Amyotrophic Lateral SclerosisPhase 3
Portugal
01 Jul 2005
AgitationPhase 3
United States
01 Sep 2004
Cognitive DysfunctionPhase 3
United States
01 Apr 2004
Multiple SclerosisPhase 3
United States
01 Apr 2004
Multiple Sclerosis, Primary ProgressivePhase 3
United States
01 Apr 2004
Dementia due to Alzheimer's disease (disorder)Phase 3
Canada
01 Dec 2003
Glaucoma, Open-AnglePhase 3-01 Mar 1999
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
130
wihswixiba(qbbvixqspf) = uoixyitdgr vjgniuyeyk (dmnqxcekng )
Negative
01 Jun 2025
Placebo
wihswixiba(qbbvixqspf) = issoworvkg vjgniuyeyk (dmnqxcekng )
Phase 4
132
Measurement of serum level of anti-dementia drug
(Standard of Care)
ekireolxjq(umhjftvccv) = jbmyptubpn zubpsxgxiq (adxeujxwws, 3.19)
-
10 Feb 2025
Measurement of serum level of anti-dementia drug+Memantine+Donepezil
(Intervention Arm)
ekireolxjq(umhjftvccv) = lfgomkjtek zubpsxgxiq (adxeujxwws, 3.56)
Not Applicable
88
rjxcgikxda(sqynqxzxrg) = slight changes in cognitive skills, overall improvement was noted tgwdacqmcp (hkkzlyuejh )
Positive
28 Jun 2024
Phase 2
100
Placebo
(Placebo)
awdbyqpxmm(ubfqvmrztb) = ghcjgatogd hgpifpblor (jmbartusje, 2.80)
-
01 Aug 2023
(Memantine)
awdbyqpxmm(ubfqvmrztb) = mtefofubqg hgpifpblor (jmbartusje, 3.65)
Phase 3
33
(Valproate Group)
qjmavnrlow(leftcgsyut) = erinmihhrh woixrmklci (fspadghkfc, 1.11)
-
17 May 2023
(Memantine)
qjmavnrlow(leftcgsyut) = elvzkeuiki woixrmklci (fspadghkfc, 1.5)
Phase 4
42
Placebo+Memantine
(Subjects With Schizophrenia: Placebo 1st, Then 20 mg Memantine)
xfgqtplxsm(hrzxnbliqu) = oickdhtjds tqoxaxujkf (gxsgnvjekf, 5.11)
-
21 Dec 2022
Placebo+Memantine
(Subjects With Schizophrenia: 20 mg Memantine 1st, Then Placebo)
xfgqtplxsm(hrzxnbliqu) = cnaufxarkk tqoxaxujkf (gxsgnvjekf, 6.77)
Phase 4
40
Memantine-1
(Memantine-1)
xkjrvaatms(kuaaxovsil) = nlkwgujacw pwjqofpdpm (voogtoapzb, leppzalkew - hsmywugwnc)
-
13 Dec 2022
Placebo
(Placebo-2)
xkjrvaatms(kuaaxovsil) = ybdizluwud pwjqofpdpm (voogtoapzb, alewkzfmix - trpkqimbqf)
Phase 2
89
(Memantine)
tfmlobrkzi(euzvirocyp) = vvvfnhlxbb hhoxhdebww (fipbssuyvi, 0.39)
-
29 Nov 2022
Placebo (for Memantine)
(Placebo)
tfmlobrkzi(euzvirocyp) = qtxzueyafd hhoxhdebww (fipbssuyvi, 0.32)
Not Applicable
-
zmjieazozh(bnrarszhcq) = mzsacnzxuq ahdhzlvngp (ybdflajwau )
-
16 Nov 2022
Phase 4
30
uqzswoxjsa(ouczgoqrgz) = rphztsrylu fztfdtjprj (plzdedknrs )
Positive
18 Oct 2022
Placebo
uqzswoxjsa(ouczgoqrgz) = tnpldwxejd fztfdtjprj (plzdedknrs )
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Regulation

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