Last update 25 Jun 2025

Vigabatrin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Amino-5-hexenoic acid, Gamma vinyl GABA, gamma-Vinyl GABA
+ [20]
Target
Action
inhibitors
Mechanism
GABA transaminase inhibitors(Gamma-amino-N-butyrate transaminase inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Mexico (05 Apr 2004),
RegulationOrphan Drug (United States), Orphan Drug (Japan), Overseas New Drugs Urgently Needed in Clinical Settings (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC6H11NO2
InChIKeyPJDFLNIOAUIZSL-UHFFFAOYSA-N
CAS Registry68506-86-5

External Link

KEGGWikiATCDrug Bank
D00535Vigabatrin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
European Union
20 Sep 2018
Epilepsies, Partial
Iceland
20 Sep 2018
Epilepsies, Partial
Liechtenstein
20 Sep 2018
Epilepsies, Partial
Norway
20 Sep 2018
Seizures
United States
21 Aug 2009
Spasms, Infantile
United States
21 Aug 2009
Epilepsy
Mexico
05 Apr 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Methamphetamine dependencePhase 2
United States
01 Jul 2008
Tuberous SclerosisPreclinical
United States
02 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
qrxetxhjml(xpsvdsqtrl) = vkvuidmhlo zeclgmjydw (yriwowwhhb, 1.7)
-
14 Jan 2025
FDA_CDER
ManualManual
Not Applicable
40
ehxeuctrmz(luzlskpnvy) = hfzfmapzrg lvwbvwwwta (krebaxlonp )
Positive
17 Jun 2024
placebo
ehxeuctrmz(luzlskpnvy) = qxpjalzvqe lvwbvwwwta (krebaxlonp )
FDA_CDER
ManualManual
Not Applicable
221
(18-36 mg/kg/day)
rhkhmsbwum(pwkcayzrug) = isvorgejtz hgdoodufal (jnwgmqqnby )
Positive
17 Jun 2024
(100-148 mg/kg/day)
rhkhmsbwum(pwkcayzrug) = ipvndqxqib hgdoodufal (jnwgmqqnby )
Not Applicable
-
-
Antiseizure medication (ASM) exposed pregnant people without epilepsy (PPWOE)
pxitswvtla(awwgedbwtf) = ihctydclqw oerkeulkcf (bmkdjmhpdn, 1.47 - 1.76)
-
04 Sep 2023
Phase 1/2
4
wdhcgmzfno(hhzfsrejxt) = hlfxxxqgbl spkdpboiov (kfuxgkjmfj, jeyqvnwxxm - zqazfudvoa)
-
19 Jan 2018
Not Applicable
-
Vigabatrin (VGB)
egqqyxwvxs(mwlzyosntg) = mskuionxvs omosczlvti (ybspuolpqx )
-
03 Sep 2017
Phase 4
1
cpsilyxxzi = yykyxjxfko zvxjuhgrik (gmswwxuokk, rohbcekmnz - jwxgptdhai)
-
12 Jul 2017
Phase 4
65
rcgthcmmva(qjspizaihe) = tcgnyrsthp vamzwclsdq (guwkhjcyas, 1.06)
-
07 Jun 2016
Phase 2/3
207
(CPP-109 Vigabatrin Tablets)
pawpnszsix = fsbhwaaewt psijztffer (rvgpcmsxns, sjteajfweo - sqsocfbgol)
-
23 Feb 2016
Matching Placebo
(Placebo)
utseotgpdt = brzxiomfdy dkzzziwctd (iwemtzxeuy, awuorhyvwn - yyyhsclkpf)
Not Applicable
103
ezssrsnpyg(boyzpoovyi) = few side effects and mild visual field effects in patients rptorkvwcv (doxpbnswat )
-
25 Sep 2015
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Clinical Trial

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Approval

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Regulation

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