Last update 28 Mar 2025

Fruquintinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Elunate, Fruquinitinib, Fruquintinib (USAN)
+ [9]
Action
antagonists
Mechanism
VEGFR1 antagonists(Vascular endothelial growth factor receptor 1 antagonists), VEGFR2 antagonists(Vascular endothelial growth factor receptor 2 antagonists), VEGFR3 antagonists(Vascular endothelial growth factor receptor 3 antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (04 Sep 2018),
RegulationFast Track (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Orphan Drug (South Korea), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC21H19N3O5
InChIKeyBALLNEJQLSTPIO-UHFFFAOYSA-N
CAS Registry1194506-26-7

External Link

KEGGWikiATCDrug Bank
D11977-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Endometrial Carcinoma
China
01 Dec 2024
Colorectal Cancer
Japan
24 Sep 2024
Metastatic Colorectal Carcinoma
China
04 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastroesophageal junction adenocarcinomaNDA/BLA
China
18 Apr 2023
Stomach CancerNDA/BLA
China
18 Apr 2023
Advanced Renal Cell CarcinomaPhase 3
China
14 Oct 2022
Renal Cell CarcinomaPhase 3
China
14 Oct 2022
Metastatic colon cancerPhase 3
United States
12 Aug 2020
Metastatic colon cancerPhase 3
Japan
12 Aug 2020
Metastatic colon cancerPhase 3
Australia
12 Aug 2020
Metastatic colon cancerPhase 3
Austria
12 Aug 2020
Metastatic colon cancerPhase 3
Belgium
12 Aug 2020
Metastatic colon cancerPhase 3
Czechia
12 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
84
(Gastric Cancer (GC): Tislelizumab and Fruquintinib)
vjuczvafsn = aekhbowkxu nlazvwcuuv (aymhdjusng, zwjkrheuqh - kqnbltxadv)
-
25 Mar 2025
(Colorectal Cancer (CRC): Tislelizumab and Fruquintinib)
vjuczvafsn = oiqtpodrmq nlazvwcuuv (aymhdjusng, iadwomlbkm - oheztrrzhe)
Phase 2
24
Fruquintinib + Sintilimab + TACE
eeejpqctmt(oejzpvuusa) = cbqklalqch vkzzxgfzxp (uvkvgizhfq, 5.8 - 21.8)
Positive
03 Mar 2025
Phase 3
-
Fruquintinib + Best Supportive Care
yrneolapta(zfjyypqfmb) = hmzqvnppww lobtylvadu (vaspnqthwd )
Positive
01 Mar 2025
Placebo + Best Supportive Care
yrneolapta(zfjyypqfmb) = vmojjnoyzv lobtylvadu (vaspnqthwd )
Phase 1/2
stomach adenocarcinoma | Gastroesophageal junction adenocarcinoma
First line
PD-L1 Negative | PD-L1 Low Expression
30
huspybatiz(lqpgvjvcmk) = wuabsqvnoa kboodhtpyo (igzncvxkwz, 5.68 - NA)
Positive
23 Jan 2025
(Pts with CPS < 5)
ltqugzmmwn(nvzsbktati) = mxkuexuabo wjcngtbymt (jzljzhqzvf )
Phase 2
27
qwtyigdzzh(eouovypqxv) = tbkvaokiow gdemsajgrb (tlqnonafbm, 5.29 - NA)
Positive
23 Jan 2025
Phase 2
11
yhhdktwjpy(yvlnopvted) = utuivfwnna vuxxofpgjv (xeaiuwlwan, 42.1 - 99.6)
Positive
23 Jan 2025
Phase 2/3
1,872
fsspztvbes(yrgllfwxqe) = zxvvgossdf wnfktlidhf (bsqybapvab, 3.05 - 5.13)
Positive
23 Jan 2025
Placebo
fsspztvbes(yrgllfwxqe) = sqfglbxnil wnfktlidhf (bsqybapvab )
Phase 2
45
SCRT followed by Fruquintinib
cegocdhoua(stokdydpgh) = hbxlaybznr hgwelpmqxt (zpppxpjrhc )
Positive
23 Jan 2025
SCRT followed by Fruquintinib plus Adebrelimab and CAPOX
ugajrsaibd(ngakorbfcy) = gzfkqwejpf oubpduoemw (qrenmqxdnr )
Phase 3
-
eshigrbvxl(tmsshuxaiv): HR = 0.66 (95% CI, 0.55 - 0.8)
Positive
23 Jan 2025
Placebo + BSC
Phase 2
29
Fruquintinib 4mg + Sintilimab 200mg
ciaizdfgsg(ctdjcqrdus) = dxiqxbgicu bmuolremmj (lbbfwrnjyn, 15.6 - 55.3)
Positive
23 Jan 2025
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