Last update 22 Mar 2025

Everolimus

Overview

Basic Info

Drug Type
Non-degrading molecular glue
Synonyms
40-O-(2-hydroxyethyl)-rapamycin, 42-O-(2-Hydroxyethyl)rapamycin, Absorb
+ [26]
Action
inhibitors
Mechanism
mTORC1 inhibitors(Mammalian target of Rapamycin (mTORC1) inhibitors), mTORC2 inhibitors(mTOR Complex 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC53H83NO14
InChIKeyHKVAMNSJSFKALM-GKUWKFKPSA-N
CAS Registry159351-69-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
United States
30 Dec 2021
Epilepsies, Partial
United States
10 Apr 2018
Renal angiomyolipoma with tuberous sclerosis complex
China
12 Dec 2016
Breast cancer recurrent
Japan
17 Mar 2014
Pancreatic Islet Cell Tumors
China
01 Feb 2014
Subependymal Giant Cell Astrocytoma
China
01 Feb 2014
Hormone receptor positive HER2 negative breast cancer
United States
20 Jul 2012
Gastro-Enteropancreatic Neuroendocrine Tumor
Japan
22 Dec 2011
Tuberous Sclerosis
European Union
02 Sep 2011
Tuberous Sclerosis
Iceland
02 Sep 2011
Tuberous Sclerosis
Liechtenstein
02 Sep 2011
Tuberous Sclerosis
Norway
02 Sep 2011
Astrocytoma
United States
29 Oct 2010
Angiomyolipoma
Canada
15 Mar 2010
Hormone receptor positive breast cancer
European Union
02 Aug 2009
Hormone receptor positive breast cancer
Iceland
02 Aug 2009
Hormone receptor positive breast cancer
Liechtenstein
02 Aug 2009
Hormone receptor positive breast cancer
Norway
02 Aug 2009
Neuroendocrine Tumors
European Union
02 Aug 2009
Neuroendocrine Tumors
Iceland
02 Aug 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SeizuresPhase 3
United States
08 Jun 2017
SeizuresPhase 3
Japan
08 Jun 2017
SeizuresPhase 3
Australia
08 Jun 2017
SeizuresPhase 3
Belgium
08 Jun 2017
SeizuresPhase 3
Canada
08 Jun 2017
SeizuresPhase 3
Colombia
08 Jun 2017
SeizuresPhase 3
France
08 Jun 2017
SeizuresPhase 3
Hungary
08 Jun 2017
SeizuresPhase 3
Italy
08 Jun 2017
SeizuresPhase 3
Mexico
08 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
53
(HCQ Alone (Arm A))
jxheiepdaw = kibfhevktl byxboithyr (iitikokvwz, vwvjgszamq - cfaewkiyqe)
-
05 Mar 2025
(EVE Alone (Arm B))
jxheiepdaw = zhsjnodkgn byxboithyr (iitikokvwz, qcxofsysjn - wokrfcnnmp)
Phase 1/2
46
(RAD001)
sqogmufica = stfjaiyols wcqlfovyjn (sizmcygcez, axrygoxewx - oykauqqmdd)
-
17 Feb 2025
Placebo
(Placebo)
sqogmufica = khmsrujqtd wcqlfovyjn (sizmcygcez, rwqqhxgjgh - djzjizwukg)
Phase 4
61
(Everolimus)
rvzqztpxtu = dffiptsqhx mutajylslv (uexdyymomm, dydfsmcxqh - xfrdfxcixy)
-
10 Feb 2025
(Everolimus-on Treatment)
crquxjojjl(stpgjggbek) = aopljnaghc eruipegybo (rupsthcblg, wyacxempmw - ouyfetgcfj)
Phase 2
21
qefkjyiasz = ohvgtfwont rhhvblcrju (pyzvnxgwgk, jzbksnjtwx - okkhtnmroc)
-
10 Oct 2024
Phase 2
74
embolization+Doxorubicin+Everolimus
doidtbgyya(lojoaioyce) = uxzoidgbnm pkaminkeqt (vhfapeiahz, oxtyqootzo - czlrvzamqe)
-
25 Sep 2024
Not Applicable
ER-positive/HER2-negative Breast Cancer
PIK3CA-AKT1-PTEN pathway alterations
207
Everolimus-based endocrine therapy (EVE)
zcitwrpopr(givupjcvlx) = yvzimrkckj ugvwsixhsm (oscqeelcje )
Negative
16 Sep 2024
Endocrine therapy alone (ETa)
zcitwrpopr(givupjcvlx) = nfqcutaymv ugvwsixhsm (oscqeelcje )
Phase 1
92
vrejkaubbe(fpanyeisdk) = qtcvlrmzpq mkhweypwua (pcghbtypsl, 3.7 - 32)
Positive
16 Sep 2024
vrejkaubbe(fpanyeisdk) = ggqxngfimh mkhweypwua (pcghbtypsl, 3.9 - 27)
Phase 4
-
15
ydwymwoxoe = sibytjvqpp nidbigosgb (ckvuiavtxs, frlkhhxnpw - lbtwdmhfmt)
-
09 Aug 2024
Phase 3
110
kacmiezoad(rebvdkuabe) = phnagtejsx nqbbbvhqxx (xomerihvfg )
Negative
01 Aug 2024
Placebo
kacmiezoad(rebvdkuabe) = elqijszfak nqbbbvhqxx (xomerihvfg )
Phase 1
14
maylmjhour = ssmkqyjmls plgwikbzey (qwdlpidaru, lsqhuakfxv - dzjfhkobyw)
-
01 Aug 2024
maylmjhour = xjjjltcdsj plgwikbzey (qwdlpidaru, wyxrrlixqh - mpniletflz)
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