Last update 16 May 2024

Phenazopyridine Hydrochloride

Last update 16 May 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

SummaryPhenazopyridine, a diminutive molecule, serves primarily as an analgesic agent for urinary tract pain. Its mode of action involves alleviating the discomfort associated with urinary tract infections, bladder inflammation, and other related maladies. The inception of phenazopyridine's use dates back to 1928 and, since then, it has burgeoned into a popular choice for individuals experiencing arduous urination or other urinary tract symptoms. It is crucial to note, however, that while phenazopyridine effectively mitigates pain, it does not remedy the underlying condition that engenders the discomfort. Thus, healthcare professionals must supervise phenazopyridine use as it may interact adversely with other medications and engender potential side effects.

Drug Type

Small molecule drug

Synonyms

2,6-Diamino-3-(phenylazo)pyridine, 2,6-Diamino-3-phenylazopyridine, 3-(Phenylazo)-2,6-pyridinediamine

+ [7]

Target-

Mechanism-

Therapeutic Areas

Nervous System Diseases

Active Indication

Pain

Inactive Indication

DysuriaUrinary Tract Infections

Originator Organization-

Active Organization

Karen Pharmaceutical Co. Ltd.

Inactive Organization

Amneal Intermediate, Inc.

Pro Doc LtéeLaboratórios Osório de Moraes Ltda

Drug Highest PhaseApproved

First Approval Date

US (01 Jan 1928)

Regulation-

Structure

Molecular FormulaC11H12ClN5

InChIKeyQQBPIHBUCMDKFG-UHFFFAOYSA-N

CAS Registry136-40-3

View All Structures (2)

Clinical Trials associated with Phenazopyridine Hydrochloride

IRCT20230222057495N11 / Recruiting

Bioequivalence study of phenazopyridine hydrochloride 100 mg tablets of Mehr Darou pharmaceutical company compared to the phenazopyridine hydrochloride 100 mg sample of Pfizer in Germany on healthy volunteers.

Start Date16 Dec 2023

Sponsor / Collaborator-

IRCT20200623047902N31 / Suspended

Bioequivalence study of Phenazopyridine 100mg tablet manufactured by Ronak Pharm versus originator brand in healthy volunteers in the fasted condition

Start Date06 Jul 2023

Sponsor / Collaborator-

NCT03755089 / Unknown statusPhase 4IIT

Oral Phenazopyridine Versus Intravesical Lidocaine for Office OnabotulinumtoxinA Analgesia: A Randomized Controlled Trial

OnabotulinumtoxinA (Botox®) bladder injections are a highly effective treatment for overactive bladder and urgency urinary incontinence. The procedure is typically performed in the office setting with one of two medications to control comfort. However, the effectiveness of these medications has never been compared. The goal of this study is to determine which medication is better at providing comfort during bladder Botox® injections.

Start Date01 Nov 2018

Sponsor / Collaborator

Women & Infants Hospital of Rhode Island

100 Clinical Results associated with Phenazopyridine Hydrochloride

100 Translational Medicine associated with Phenazopyridine Hydrochloride

100 Patents (Medical) associated with Phenazopyridine Hydrochloride

302

Literatures (Medical) associated with Phenazopyridine Hydrochloride

08 Feb 2024·Cureus

Comprehensive Review of Urinary Tract Infections in Renal Transplant Recipients: Clinical Insights and Management Strategies

Review

Author: Bharuka, Vidhi ; Meshram, Revat ; Munjewar, Pratiksha K

Urinary tract infections (UTIs) pose a significant challenge in the care of renal transplant recipients. This comprehensive review explores this population's multifaceted landscape of UTIs, emphasizing the importance of early diagnosis and tailored management strategies. Renal transplant recipients face an elevated risk of UTIs due to immunosuppression, altered urinary tract anatomy, and complex comorbidities. Complications of UTIs can lead to graft dysfunction and systemic illness, underscoring the need for effective management. The emergence of multidrug-resistant uropathogens adds complexity to treatment, highlighting the importance of targeted antibiotic therapy. Antibiotics are the most commonly prescribed drugs for UTIs, with nitrofurantoin, fosfomycin, amoxicillin, and amoxicillin-clavulanate potassium being some of the commonly used antibiotics. However, the emergence of multidrug-resistant uropathogens has led to the exploration of alternative treatments, such as bacteriophage therapy, as a potential alternative against multidrug-resistant uropathogenic bacteria. Analgesics such as phenazopyridine can be prescribed to relieve discomfort associated with UTIs. Estrogen therapy has also been suggested as a potential treatment option for UTIs, particularly in postmenopausal women. Trimethoprim-sulfamethoxazole or trimethoprim is recommended as first-line therapy for uncomplicated UTIs. The choice of drug and therapy for UTIs depends on the severity of the infection, the causative organism, and the presence of antibiotic resistance. Preventive measures encompass pre-transplant evaluation, perioperative strategies, post-transplant follow-up, and vaccination. A multidisciplinary approach involving transplant specialists, infectious disease experts, pharmacists, and patient engagement is vital for successful care. The future of UTI management lies in ongoing research, exploring personalized medicine, novel therapies, and innovative prevention strategies. By implementing these strategies and advancing research, healthcare providers can improve graft and patient survival, enhancing the quality of care for renal transplant recipients.

01 Feb 2024·Obstetrics & Gynecology

A Systematic Review

Review

Author: Jeppson, Peter C ; Thompson, Jennifer C ; Miranne, Jeannine ; Balgobin, Sunil ; Antosh, Danielle D ; Dieter, Alexis A ; Sleemi, Ambereen ; Meriwether, Kate V ; Balk, Ethan M ; Halder, Gabriela E ; Mama, Saifuddin ; Alas, Alexandriah ; Houlihan, Sara

OBJECTIVE:To assess and compile the current level of evidence regarding successful surgical treatment of vesicovaginal fistulae and how these perioperative interventions affect anatomic, patient-centered, and adverse outcomes.DATA SOURCES:PubMed and EMBASE were searched from inception through September 9, 2022.METHODS OF STUDY SELECTION:This review included comparative studies (of any sample size) and single-group studies (1,000 or more participants) of primary or recurrent vesicovaginal fistula (ie, vesicovaginal fistula, urethrovaginal fistula, and bladder neck–vaginal fistula). We evaluated preintervention assessment or management, various techniques for intraoperative management, and postoperative management. Outcomes of interest included anatomic and objective outcomes (such as successful repair, fistula closure, urinary incontinence, recurrent fistula, perioperative complications) and subjective outcomes (such as voiding symptoms and quality of life). Abstracts and full-text articles were screened in duplicate, and study descriptions and findings were extracted into standardized extraction forms. Risk of bias was assessed independently by two investigators and adjudicated by a third. Study quality was summarized with standardized tools. We conducted random-effects model and restricted maximum-likelihood meta-analyses of relative risks when at least three studies compared similar interventions and reported similar outcome measures.TABULATION, INTEGRATION, AND RESULTS:Forty-six studies met the inclusion criteria. Studies were categorized into 11 domains: 1) preoperative assessment, 2) preoperative and postoperative physical therapy, 3) route of surgery, 4) incorporation of a flap, 5) trimming, 6) layered closure, 7) intraoperative antibiotics, 8) fibrin glue, 9) fascial sling, 10) postoperative Foley catheter duration, and 11) quality of life. Although the strength of the data is insufficient, preoperative phenazopyridine, physical therapy, layered closure, and intraoperative antibiotics seemed to improve the rate of successful fistula repair. Route of surgery (vaginal vs abdominal laparotomy) was determined primarily by surgeon preference and showed no difference in successful fistula repair. In addition, use of interpositional flaps, trimming fistula edges, fibrin glue, and fascial sling did not show significant improvement in rates of fistula cure. Overall, quality-of-life scores improved postoperatively regardless of route of repair and use of interpositional flaps.CONCLUSION:Our findings highlight the limited information available to guide evidence-based treatment of vesicovaginal fistula repair. Overall, high-quality evidence is lacking to provide guidelines; therefore, expert opinion remains the primary influence for fistula repair recommendations.SYSTEMATIC REVIEW REGISTRATION:PROSPERO, CRD42021214948.

01 Dec 2023·International Urogynecology Journal

Efficacy of methenamine with methylthioninium in the treatment of dysuria: a randomized clinical study

Article

Author: Pereira, Márcio Antônio ; Filho, Carlos Isaia ; Hachul, Helena ; Neto, Felício Savioli

AbstractIntroduction and hypothesisDysuria is a common symptom present in several urological and gynecological conditions. Management relies on the underlying disease but may require additional symptomatic treatment. This study evaluated the combination of methenamine 250 mg and methylthioninium chloride 20 mg in the treatment of dysuria versus phenazopyridine.MethodsThis was a multicenter, single-blind, randomized, superiority clinical trial, including individuals over 18 with dysuria and a score ≥ 5 points on the pre-treatment categorical scale for pain. The primary outcome was the proportion of participants presenting excellent clinical response within 24 h after treatment. Improvement up to 72 h, time to reach improvement, sustained healing, investigators’ opinion, and safety were also evaluated.ResultsThree hundred and fifteen participants were evaluated. Demographic characteristics and symptoms of dysuria were comparable between groups at baseline. The difference in the excellent response rate between treatments within 24 h was 12.7% (95% CI 6.16, 19.21) for pain, 9.4% (95% CI 3.32, 15.39) for burning, and 12.7% (95% CI 6.37, 18.99) for burning on urination, all in favor of the test drug, which was also superior from 36 to 48 h. Treatments were similar concerning time to reach the absence of symptoms and in the percentage of participants with sustained healing after 72 h.ConclusionsThe association of methenamine with methylthioninium is superior to phenazopyridine in the treatment of dysuria.

News (Medical) associated with Phenazopyridine Hydrochloride

31 Jan 2023

·www.prnewswire.com

Interstitial cystitis (IC) drugs market size to increase by USD 369.58 million: Analysis of major players as well as the key contributor region - Technavio

North America will account for 35% of the global interstitial cystitis (IC) drugs market NEW YORK, Jan. 30, 2023 /PRNewswire/ -- North America will account for 35% of the global Interstitial cystitis (IC) drugs market growth. The increasing cases of interstitial cystitis and the rise in research funding are driving the growth of the regional market. The Interstitial Cystitis Drugs Market by Type, Distribution Channel, and Geography - Forecast and Analysis 2023-2027 report has been published by Technavio. Market growth is estimated to accelerate at a CAGR of 5.9% and register an incremental growth of USD 369.58 million during the forecast period. The report provides a comprehensive analysis of growth opportunities at regional levels, new product launches, the latest trends, and the post-pandemic recovery of the global market. Download a PDF Sample Report Continue Reading Technavio has announced its latest market research report titled Global Interstitial Cystitis Drugs Market Company Profiles The interstitial cystitis (IC) drugs market report includes information on the key products and recent developments of leading vendors, including: Amneal Pharmaceuticals Inc: The company offers interstitial cystitis and other related drugs such as Pyridium. Astellas Pharma Inc: The company offers interstitial cystitis drugs such as Rosiptor. Bayer AG: The company offers interstitial cystitis drugs such as Aleve and Aktion. Eli Lilly and Co: The company offers interstitial cystitis and other related drugs such as Tadalafil. Johnson and Johnson: The company offers interstitial cystitis drugs such as Elmiron. Kyorin Pharmaceutical Co. Ltd. Mission Pharmacal Co. Perrigo Co. Plc Pfizer Inc. Purdue Pharma LP Seikagaku Corp. To gain access to more vendor profiles available with Technavio, buy the report! Market Dynamics The market is driven by factors such as the high prevalence of interstitial cystitis, increasing awareness of interstitial cystitis, and increasing grants for research on interstitial cystitis. However, the lack of approved drugs is hindering the market growth. Competitive Analysis The competitive scenario categorizes companies based on various performance indicators. Some of the factors considered include the financial performance of companies over the past few years, growth strategies, product innovations, new product launches, investments, and growth in market share, among others. Request a Sample Market Segmentation By type, the market is segmented into oral therapy and intravesical therapy. The oral therapy segment accounted for the largest share of the market. By geography, the market is segmented into North America, Europe, Asia, and Rest of World (ROW). North America held the largest share of the market. Related Reports: Chronic Obstructive Pulmonary Disease Drugs Market by Product, Distribution Channel and Geography - Forecast and Analysis 2023-2027: The chronic obstructive pulmonary disease drugs market is estimated to grow at a CAGR of 6.09% between 2022 and 2027. The size of the market is forecast to increase by USD 6,654.49 million. The rising prevalence of COPD is notably driving the market growth, although factors such as the high cost of conducting clinical trials in COPD may impede the market growth. Allergy Immunotherapies Market by Product, Type, and Geography - Forecast and Analysis 2023-2027: The allergy immunotherapies market is estimated to grow at a CAGR of 8.95% between 2022 and 2027. The size of the market is forecast to increase by USD 1,010.37 million. The increasing prevalence of allergies is notably driving the market growth, although factors such as trial failures may impede the market growth. Technavio's library includes over 17,000+ reports, covering more than 2,000 emerging technologies. Subscribe to our "Basic Plan" at just USD 5,000 and get lifetime access to Technavio Insights What are the key data covered in this interstitial cystitis (IC) drugs market report? CAGR of the market during the forecast period Detailed information on factors that will drive the growth of interstitial cystitis (IC) drugs market between 2023 and 2027 Precise estimation of the size of interstitial cystitis (IC) drugs market and its contribution to the parent market Accurate predictions about upcoming trends and changes in consumer behavior Growth of interstitial cystitis (IC) drugs market across North America, Europe, Asia, and Rest of World (ROW) A thorough analysis of the market's competitive landscape and detailed information about vendors Comprehensive analysis of factors that will challenge the growth of interstitial cystitis (IC) drugs market vendors Browse for Technavio "Health Care" Research Reports Table of Content 1 Executive Summary 2 Market Landscape 2.1 Market ecosystem Exhibit 01: Parent market Exhibit 02: Market characteristics 2.2 Value chain analysis Exhibit 03: Value chain analysis: Pharmaceuticals 3 Market Sizing 3.1 Market definition Exhibit 04: Offerings of vendors included in the market definition 3.2 Market segment analysis Exhibit 05: Market segments 3.3 Market size 2020 3.4 Market outlook: Forecast for 2020 - 2025 Exhibit 06: Global - Market size and forecast 2020 - 2025 ($ million) Exhibit 07: Global market: Year-over-year growth 2020 - 2025 (%) 4 Five Forces Analysis 4.1 Five forces summary Exhibit 08: Five forces analysis 2020 & 2025 4.2 Bargaining power of buyers Exhibit 09: Bargaining power of buyers 4.3 Bargaining power of suppliers Exhibit 10: Bargaining power of suppliers 4.4 Threat of new entrants Exhibit 11: Threat of new entrants 4.5 Threat of substitutes Exhibit 12: Threat of substitutes 4.6 Threat of rivalry Exhibit 13: Threat of rivalry 4.7 Market condition Exhibit 14: Market condition - Five forces 2020 5 Market Segmentation by Type 5.1 Market segments Exhibit 15: Type - Market share 2020-2025 (%) 5.2 Comparison by Type Exhibit 16: Comparison by Type 5.3 Oral therapy - Market size and forecast 2020-2025 Exhibit 17: Oral therapy - Market size and forecast 2020-2025 ($ million) Exhibit 18: Oral therapy - Year-over-year growth 2020-2025 (%) 5.4 Intravesical therapy - Market size and forecast 2020-2025 Exhibit 19: Intravesical therapy - Market size and forecast 2020-2025 ($ million) Exhibit 20: Intravesical therapy - Year-over-year growth 2020-2025 (%) 5.5 Market opportunity by Type Exhibit 21: Market opportunity by Type 6 Customer landscape 7 Geographic Landscape 7.1 Geographic segmentation Exhibit 23: Market share by geography 2020-2025 (%) 7.2 Geographic comparison Exhibit 24: Geographic comparison 7.3 North America - Market size and forecast 2020-2025 Exhibit 25: North America - Market size and forecast 2020-2025 ($ million) Exhibit 26: North America - Year-over-year growth 2020-2025 (%) 7.4 Europe - Market size and forecast 2020-2025 Exhibit 27: Europe - Market size and forecast 2020-2025 ($ million) Exhibit 28: Europe - Year-over-year growth 2020-2025 (%) 7.5 Asia - Market size and forecast 2020-2025 Exhibit 29: Asia - Market size and forecast 2020-2025 ($ million) Exhibit 30: Asia - Year-over-year growth 2020-2025 (%) 7.6 ROW - Market size and forecast 2020-2025 Exhibit 31: ROW - Market size and forecast 2020-2025 ($ million) Exhibit 32: ROW - Year-over-year growth 2020-2025 (%) 7.7 Key leading countries Exhibit 33: Key leading countries 7.8 Market opportunity by geography Exhibit 34: Market opportunity by geography ($ million) 8 Drivers, Challenges, and Trends 8.1 Market drivers 8.2 Market challenges Exhibit 35: Impact of drivers and challenges 8.3 Market trends 9 Vendor Landscape 9.1 Overview 9.2 Vendor landscape Exhibit 36: Vendor landscape 9.3 Landscape disruption Exhibit 37: Landscape disruption Exhibit 38: Industry risks 10 Vendor Analysis 10.1 Vendors covered Exhibit 39: Vendors covered 10.2 Market positioning of vendors Exhibit 40: Market positioning of vendors 10.3 Astellas Pharma Inc. Exhibit 41: Astellas Pharma Inc. - Overview Exhibit 42: Astellas Pharma Inc. - Product and service Exhibit 43: Astellas Pharma Inc. - Key news Exhibit 44: Astellas Pharma Inc. - Key offerings 10.4 Bayer AG Exhibit 45: Bayer AG - Overview Exhibit 46: Bayer AG - Business segments Exhibit 47: Bayer AG - Key news Exhibit 48: Bayer AG - Key offerings Exhibit 49: Bayer AG - Segment focus 10.5 Johnson and Johnson Inc. Exhibit 50: Johnson and Johnson Inc. - Overview Exhibit 51: Johnson and Johnson Inc. - Business segments Exhibit 52: Johnson and Johnson Inc. - Key news Exhibit 53: Johnson and Johnson Inc. - Key offerings Exhibit 54: Johnson and Johnson Inc. - Segment focus 10.6 Novartis AG Exhibit 55: Novartis AG - Overview Exhibit 56: Novartis AG - Business segments Exhibit 57: Novartis AG - Key news Exhibit 58: Novartis AG - Key offerings Exhibit 59: Novartis AG - Segment focus 10.7 Perrigo Co. Plc Exhibit 60: Perrigo Co. Plc - Overview Exhibit 61: Perrigo Co. Plc - Business segments Exhibit 62: Perrigo Co. Plc - Key news Exhibit 63: Perrigo Co. Plc - Key offerings Exhibit 64: Perrigo Co. Plc - Segment focus 10.8 Pfizer Inc. 10.9 Seikagaku Corp. Exhibit 69: Seikagaku Corp. - Overview Exhibit 70: Seikagaku Corp. - Business segments Exhibit 71: Seikagaku Corp. - Key offerings Exhibit 72: Seikagaku Corp. - Segment focus 10.10 Sun Pharmaceutical Industries Ltd. Exhibit 73: Sun Pharmaceutical Industries Ltd. - Overview Exhibit 74: Sun Pharmaceutical Industries Ltd. - Product and service Exhibit 75: Sun Pharmaceutical Industries Ltd. - Key news Exhibit 76: Sun Pharmaceutical Industries Ltd. - Key offerings 10.11 Teva Pharmaceutical Industries Ltd. Exhibit 77: Teva Pharmaceutical Industries Ltd. - Overview Exhibit 78: Teva Pharmaceutical Industries Ltd. - Business segments Exhibit 79: Teva Pharmaceutical Industries Ltd. - Key offerings Exhibit 80: Teva Pharmaceutical Industries Ltd. - Segment focus 10.12 Viatris Inc. Exhibit 81: Viatris Inc. - Overview Exhibit 82: Viatris Inc. - Business segments Exhibit 83: Viatris Inc. - Key offerings Exhibit 84: Viatris Inc. - Segment focus 11 Appendix 11.1 Scope of the report 11.2 Currency conversion rates for US$ Exhibit 85: Currency conversion rates for US$ 11.3 Research methodology Exhibit 86: Research Methodology Exhibit 87: Validation techniques employed for market sizing Exhibit 88: Information sources 11.4 List of abbreviations Exhibit 89: List of abbreviations About Us Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contact Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: SOURCE Technavio

100 Deals associated with Phenazopyridine Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D05450	Phenazopyridine Hydrochloride	G04BX06	DB01438

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Pain	CN	Karen Pharmaceutical Co. Ltd.	01 Jan 2003

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Pain	Phase 2	US	Amneal Intermediate, Inc.	01 Dec 2009
Urinary Tract Infections	Phase 1	US	Amneal Intermediate, Inc.	01 Dec 2009
Dysuria	Discovery	-	Laboratórios Osório de Moraes Ltda	01 Dec 2009

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02806713 (CTgov)	Phase 3	Urologic Diseases \| Pain, Postoperative	92	no Phenazopyridine (no Phenazopyridine)	(nobsjfesga) = bzhemtwdbw qezbgoxrmd (txgkpjgqge, brrcjwptnl - nhsjehoyvj) View more	-	05 Feb 2019
				Phenazopyridine (Phenazopyridine)	(nobsjfesga) = tgjjwbabxo qezbgoxrmd (txgkpjgqge, ewrafpouir - zdbhjtcdpp) View more
NCT02476448 (CTgov)	Not Applicable	Ureteral Diseases	176	normal saline (Normal Saline)	puyjkrbqkr(ugyxbplubx) = tybxovjeak epdnwzsyfr (pjhklwggsx, cnyqvogvno - drzahmerau) View more	-	23 Oct 2019
				Dextrose 10% (Dextrose 10%)	puyjkrbqkr(ugyxbplubx) = mgqmqnmkfb epdnwzsyfr (pjhklwggsx, tfqzqdcjqf - rlwjrefozw) View more
NCT02677623 (CTgov)	Phase 4	Ureteral Obstruction	140	Pyridium (A- Pyridium)	bmhuqbhufn(wsawpsaddo) = kscnqsoabz vruzmlymhq (fnqqvslcwf, qqcomkuszc - ykltcsltxw) View more	-	30 May 2019
				Sodium Fluorescein (B- Sodium Fluorescein)	bmhuqbhufn(wsawpsaddo) = rnentydrwj vruzmlymhq (fnqqvslcwf, odjuewzvpf - dwsjnjattn) View more
NCT03065075 (Pubmed \| Female Pelvic Med Reconstr Surg)	Phase 3	Visceral Prolapse	152	Phenazopyridine 200 mg	fbmojmzcze(xfzxgkltmj) = ozusnmcjep ndsyycnwff (lfdxsyziox )	Negative	26 Apr 2019
				No additional phenazopyridine	fbmojmzcze(xfzxgkltmj) = egftfzkxlz ndsyycnwff (lfdxsyziox )
NCT03755089 (Pubmed) Manual	Phase 4	Urinary Bladder, Overactive	100	phenazopyridine	(zsttdwrhmj): difference = -2.7 (95% CI, -11.3 to 10.7)	Negative	14 May 2022
				lidocaine
NCT03065075 (CTgov)	Phase 3	Uterine Prolapse \| Urinary Retention	152	Phenazopyridine (Phenazopyridine)	onzunswouw(zdqotepvgm) = ypsnejayqm ixsshjajfi (tupnbaatre, elabbvpaii - ahcfjwxxqh) View more	-	26 Mar 2019
				Phenazopyridine (No Phenazopyridine)	onzunswouw(zdqotepvgm) = ubsweiwwoa ixsshjajfi (tupnbaatre, jkvaklxijv - vhyqxrcubs) View more

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