Last update 06 Jun 2025

Linerixibat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Linerixibat (USAN), GSK 2330672, GSK 672
+ [2]
Target
Action
inhibitors
Mechanism
ISBT inhibitors(Ileal bile acid transporter inhibitors)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC28H38N2O7S
InChIKeyCZGVOBIGEBDYTP-VSGBNLITSA-N
CAS Registry1345982-69-5

External Link

KEGGWikiATCDrug Bank
D11539--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cholestatic pruritusNDA/BLA
United States
02 Jun 2025
Primary Biliary CholangitisNDA/BLA
United States
02 Jun 2025
PruritusPhase 2
Australia
11 Jan 2017
Diabetes Mellitus, Type 2Phase 2
United States
01 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
238
kkxnufkhpx(rukwjfppat): Difference (LS Mean) = -0.72 (95% CI, -1.15 to -0.28), P-Value = 0.001
Met
Positive
19 Nov 2024
Placebo
Phase 1
6
[14C] Linerixibat+Linerixibat
(Linerixibat 90 mg Oral Tablets + [14C] Linerixibat 100 μg IV)
ztcdpynprz(vhxpebguri) = erbwtsksnh afozcpvnsl (eeyvjseciu, 25.8)
-
26 Jun 2020
[14C]-Linerixibat
([14C]-Linerixibat 90 Milligram Oral Solution)
bgikrntgru(asvgrhcoxs) = uvhmsgydsp miamlmpxyw (davwibdcle, 95.3)
Phase 2
70
(Placebo)
rofgqmquoo(boueftifvq) = apmjdkzxbq zakpzvhosk (xwpxvfkhvo, 16.357)
-
06 Nov 2017
(GSK2330672 10 mg BID)
rofgqmquoo(boueftifvq) = ckqpiwluzq zakpzvhosk (xwpxvfkhvo, 6.500)
Phase 2
16
(Treatment A-GSK2330672 + Metformin)
vigzmzwwyj = rhegfwuvxg otxtazpfyb (bhsxuqtmgo, ywsfxfdrvj - ttolrgcwvs)
-
16 Aug 2017
Placebo+Metformin
(Treatment B-Placebo + Metformin)
vigzmzwwyj = ljqgjpjiuz otxtazpfyb (bhsxuqtmgo, kuhoubfhkq - dzpcxbfvfi)
Phase 2
22
dqsbjajnxn(xcqkiyqtqo) = Diarrhoea was the most frequent adverse event during treatment with GSK2330672 (seven with GSK2330672 vs one with placebo) and headache was the most frequent adverse event during treatment with placebo (seven with placebo vs six with GSK2330672). hnjoentpxe (widihaiyut )
Positive
18 Mar 2017
Placebo
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Regulation

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